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Atlas of Tumor Pathology of the Fischer Rat

Author : Sherman F. Stinson

Publisher : CRC Press

Page : 564 pages

File Size : 31,2 MB

Release : 1990-01-17

Category : Medical

ISBN : 9780849354625

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Book Description

This book provides a comprehensive resource of the most recent findings on the pathogenesis and pathology in the Fischer rat. Each chapter, adequately illustrated with light and electron photomicrographs, deals with a specific organ system. It includes a summary of the spontaneous neoplasms found in over 5,000 untreated control animals as well as a detailed, step by step necropsy procedure completely illustrated by photographs. It refers to a listing of common and rare tumors associated with the administration of various environmental agents obtained from over 200 carcinogenesis bioassays of the National Cancer Institute and National Toxicology Program. This work also reveals detailed information on spontaneous occurrence and the induction of neoplasms. Scientists involved in the evaluation of toxicological and carcinogenesis bioassays and investigators conducting basic and applied carcinogenesis research will find this atlas indispensable.



Pathology of the Fischer Rat

Author : Gary A. Boorman

Publisher : San Diego : Academic Press

Page : 580 pages

File Size : 36,42 MB

Release : 1990

Category : Medical

ISBN : 9780121156404

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Book Description

Studies in rodents of the toxicity and carcinogenicity of drugs, agricultural agents (e.g., pesticides and herbicides), environmental pollutants, industrial agents (e.g., solvents and intermediates), and other chemicals are the cornerstone of human safety evaluations in the development, use, and/or regulation of these agents. Those who perform the pathological evaluations from these studies need standard diagnostic criteria and pathology terminology. Pathology of the Fischer Rat is a comprehensive pathology reference text on the Fischer 344 rat, the strain widely used for safety evaluations and almost exclusively by the National Toxicology Program.****Every chapter follows the same format of introduction; embryology; normal anatomy, histology, and physiology; and congenital, degenerative, inflammatory and vascular, hyperplastic and neoplastic, miscellaneous, and toxicological lesions. The spectrum of spontaneous and treatment-related, neoplastic and nonneoplastic lesions found in each tissue is described and photographed.****The text is useful not only to pathologists but also to investigators from a variety of disciplines who use the rat as an animal model. It will also prove valuable to toxicologists, biologists, and other scientists engaged in regulatory toxicology who must make the transition from pathology results to promulgation of meaningful regulations.



Boorman's Pathology of the Rat

Author : Andrew W. Suttie

Publisher : Academic Press

Page : 750 pages

File Size : 21,80 MB

Release : 2017-12-01

Category : Medical

ISBN : 0123914892

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Book Description

Boorman's Pathology of the Rat: Reference and Atlas, Second Edition, continues its history as the most comprehensive pathology reference on rat strains for researchers across science and medicine using rat models in the laboratory. It offers readers an added emphasis on the Sprague-Dawley and Wistar rat strains that is consistent with current research across academia, government, and industry. In addition, the book provides standard diagnostic criteria, basic content on histology, histological changes that result from drug toxicity and neoplasm, pathology terminology, and four-color photographs from the NTP archive and database. With updated references and photographs, as well as coverage of all rat strains, this book is not only the standard in the field, but also an invaluable resource for toxicologists, biologists, and other scientists engaged in regulatory toxicology who must make the transition from pathology results to the promulgation of meaningful regulations. - Contains full, four color photographs from the NTP archive and database and coverage of all rat strains - Provides an organ-by-organ and system-by-system approach that presents standard diagnostic criteria and basic content on histology and histological changes - Includes comprehensive and detailed background incidence data - Presents detailed descriptive content regarding changes in rat models during research



The Laboratory Rat

Author : Mark A. Suckow

Publisher : Elsevier

Page : 929 pages

File Size : 46,66 MB

Release : 2005-12-20

Category : Science

ISBN : 0080454321

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Book Description

The Laboratory Rat, Second Edition features updated information on a variety of topics including: rat genetics and genomics, both spontaneous and induced disease; state-of-the-art technology for housing and husbandry; occupational health, and experimental models. A premier source of information on the laboratory rat that will be of interest to veterinary and medical students, senior graduate, graduate students, post-docs and researchers who utilize animals in biomedical research. - At least 50% new information than first edition - Includes topics on rat genetics and genomics, occupational health, and experimental models - The premier source of information on the laboratory rat



Background Lesions in Laboratory Animals E-Book

Author : Elizabeth Fiona McInnes

Publisher : Elsevier Health Sciences

Page : 141 pages

File Size : 26,3 MB

Release : 2011-10-24

Category : Medical

ISBN : 0702049247

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Book Description

Background Lesions in Laboratory Animals will be an invaluable aid to pathologists needing to recognize background and incidental lesions while examining slides taken from laboratory animals in acute and chronic toxicity studies, or while examining exotic species in a diagnostic laboratory. It gives clear descriptions and illustrations of the majority of background lesions likely to be encountered. Many of the lesions covered are unusual and can be mistaken for treatment-related findings in preclinical toxicity studies. The Atlas has been prepared with contributions from experienced toxicological pathologists who are specialists in each of the laboratory animal species covered and who have published extensively in these areas. - over 600 high-definition, top-quality color photographs of background lesions found in rats, mice, dogs, minipigs, non-human primates, hamsters, guinea pigs and rabbits - a separate chapter on lesions in the reproductive systems of all laboratory animals written by Dr Dianne Creasy, a world expert on testicular lesions in laboratory animals - a chapter on common artifacts that may be observed in histological glass slides - extensive references to each lesion described - aging lesions encountered in all laboratory animal species, particularly in rats in mice which are used for carcinogenicity studies



Nutrient Requirements of Laboratory Animals,

Author : National Research Council

Publisher : National Academies Press

Page : 188 pages

File Size : 14,11 MB

Release : 1995-02-01

Category : Science

ISBN : 0309051266

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Book Description

In the years since the third edition of this indispensable reference was published, a great deal has been learned about the nutritional requirements of common laboratory species: rat, mouse, guinea pig, hamster, gerbil, and vole. The Fourth Revised Edition presents the current expert understanding of the lipid, carbohydrate, protein, mineral, vitamin, and other nutritional needs of these animals. The extensive use of tables provides easy access to a wealth of comprehensive data and resource information. The volume also provides an expanded background discussion of general dietary considerations. In addition to a more user-friendly organization, new features in this edition include: A significantly expanded section on dietary requirements for rats, reporting substantial new findings. A new section on nutrients that are not required but that may produce beneficial results. New information on growth and reproductive performance among the most commonly used strains of rats and mice and on several hamster species. An expanded discussion of diet formulation and preparationâ€"including sample diets of both purified and natural ingredients. New information on mineral deficiency and toxicity, including warning signs. This authoritative resource will be important to researchers, laboratory technicians, and manufacturers of laboratory animal feed.





Psychoneuroimmunology

Author : Robert Ader

Publisher : Academic Press

Page : 1263 pages

File Size : 49,71 MB

Release : 2014-06-28

Category : Medical

ISBN : 1483258904

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Book Description

Psychoneuroimmunology, Second Edition presents reports on the relationship between the nervous and immune systems. The book is divided into four sections. The first section details the role of neural structures and neurotransmitter signals in communication with the immune system. It documents the extensive neural connections with organs of the immune system; the dynamics of noradrenergic sympathetic innervation of spleen and thymus; and the evidence for immune signaling of the CNS. Part II elaborates the role of hormones in the modulation of immune functions; the basis for bidirectional communication between the neuroendocrine and immune systems; and the potential physiological implications of these neuroendocrine-immune system interactions. The third part addresses behavioral influences on immune response; the effects of conditioning, stress and social interactions in modulating immune responses; and the behavioral consequences of experimentally altered or genetically determined immunologic states. The final section presents the effects of psychosocial factors on immune responses and the potential impact of behavioral interventions in modulating immunity in healthy human subjects and in patients with AIDS. Neuroscientists, endocrinologists, and immunologists will find the book interesting.



Pathology of Laboratory Rodents and Rabbits

Author : Stephen W. Barthold

Publisher : John Wiley & Sons

Page : 388 pages

File Size : 14,49 MB

Release : 1991-01-16

Category : Medical

ISBN : 1118824245

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Book Description

Now in its fourth edition, Pathology of Laboratory Rodents and Rabbits has become a standard text for veterinary pathologists, laboratory animal veterinarians, students, and others interested in these species. • The standard reference on the pathogenesis and cardinal diagnostic features of diseases of mice, rats, hamsters, gerbils, guinea pigs, and rabbits • Expanded coverage of rabbit disease, normal anatomic features, and biology • Over 450 color photographs illustrating gross and microscopic pathology • Companion website offering images from the text in PowerPoint



Target Organ Pathology

Author : J. Turton

Publisher : CRC Press

Page : 456 pages

File Size : 27,81 MB

Release : 1997-10-06

Category : Medical

ISBN : 0203481925

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Book Description

The major organs of the body are targets for chemically-induced effects in animals and humans. This book reviews the mechanisms of these toxic effects and the structure/functional changes which occur in the target organ tissues as a result.