Plink, Plink, Plink


Book Description

Describes the various noises heard at night.




Bang Bang Plink Plink


Book Description

Toddlers will enjoy turning the sturdy board pages to discover 11 bright illustrations with animals and objects and the sounds shown in big bold letters, and across the page, the name of the "soundmaker", also in easy-to-read letters. Snappy Sounds are ideal for lap-time reading with an adult or older sibling, and as a read-alone activity for toddlers and very early readers. They are sure to become favourites. AUTHOR: Jolie Dobson is the author of The Duct Tape Book. AGES: 2-4 SELLING POINTS: Features 11 small and large music-makers. The Snappy Sounds series are books of colourful fun for toddlers. These bright and colourful board books are bold introductions to matching sound and objects -- for young kids. Colour illustrations Titles is series: Bang Bang Plink Plink Beep Beep Choo Choo Ring Ring Pop Pop Snap Snap Woof Woof




Statistical Population Genomics


Book Description

This open access volume presents state-of-the-art inference methods in population genomics, focusing on data analysis based on rigorous statistical techniques. After introducing general concepts related to the biology of genomes and their evolution, the book covers state-of-the-art methods for the analysis of genomes in populations, including demography inference, population structure analysis and detection of selection, using both model-based inference and simulation procedures. Last but not least, it offers an overview of the current knowledge acquired by applying such methods to a large variety of eukaryotic organisms. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, pointers to the relevant literature, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Statistical Population Genomics aims to promote and ensure successful applications of population genomic methods to an increasing number of model systems and biological questions. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.




Genome Data Analysis


Book Description

This textbook describes recent advances in genomics and bioinformatics and provides numerous examples of genome data analysis that illustrate its relevance to real world problems and will improve the reader’s bioinformatics skills. Basic data preprocessing with normalization and filtering, primary pattern analysis, and machine learning algorithms using R and Python are demonstrated for gene-expression microarrays, genotyping microarrays, next-generation sequencing data, epigenomic data, and biological network and semantic analyses. In addition, detailed attention is devoted to integrative genomic data analysis, including multivariate data projection, gene-metabolic pathway mapping, automated biomolecular annotation, text mining of factual and literature databases, and integrated management of biomolecular databases. The textbook is primarily intended for life scientists, medical scientists, statisticians, data processing researchers, engineers, and other beginners in bioinformatics who are experiencing difficulty in approaching the field. However, it will also serve as a simple guideline for experts unfamiliar with the new, developing subfield of genomic analysis within bioinformatics.




Genetic Dissection of Complex Traits


Book Description

The field of genetics is rapidly evolving and new medical breakthroughs are occuring as a result of advances in knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Five sections on the latest advances in complex traits Methods for testing with ethical, legal, and social implications Hot topics include discussions on systems biology approach to drug discovery; using comparative genomics for detecting human disease genes; computationally intensive challenges, and more




Houndsley and Catina Plink and Plunk


Book Description

A charming tale about paddling past fears with the help of true friends. Houndsley loves to canoe. Catina loves to ride bikes. But when Houndsley takes Catina out canoeing, she chatters the whole time, drowning out the sounds Houndsley loves, like the call of birds or the plink and plunk of the paddles. And when Catina wants to go biking, Houndsley balks at going, even though Bert says he wants to come along. What is wrong with Catina? And what is wrong with Houndsley? Luckily, with Bert’s help, they discover that the things you’re afraid of are easier to do with a good friend or two at your side.




Genome-Wide Association Studies and Genomic Prediction


Book Description

With the detailed genomic information that is now becoming available, we have a plethora of data that allows researchers to address questions in a variety of areas. Genome-wide association studies (GWAS) have become a vital approach to identify candidate regions associated with complex diseases in human medicine, production traits in agriculture, and variation in wild populations. Genomic prediction goes a step further, attempting to predict phenotypic variation in these traits from genomic information. Genome-Wide Association Studies and Genomic Prediction pulls together expert contributions to address this important area of study. The volume begins with a section covering the phenotypes of interest as well as design issues for GWAS, then moves on to discuss efficient computational methods to store and handle large datasets, quality control measures, phasing, haplotype inference, and imputation. Later chapters deal with statistical approaches to data analysis where the experimental objective is either to confirm the biology by identifying genomic regions associated to a trait or to use the data to make genomic predictions about a future phenotypic outcome (e.g. predict onset of disease). As part of the Methods in Molecular Biology series, chapters provide helpful, real-world implementation advice.




Blueberries for Sal


Book Description

What happens when Sal and her mother meet a mother bear and her cub? A Caldecott Honor Book! Kuplink, kuplank, kuplunk! Sal and her mother a picking blueberries to can for the winter. But when Sal wanders to the other side of Blueberry Hill, she discovers a mama bear preparing for her own long winter. Meanwhile Sal's mother is being followed by a small bear with a big appetite for berries! Will each mother go home with the right little one? With its expressive line drawings and charming story, Blueberries for Sal has won readers' hearts since its first publication in 1948. "The adventures of a little girl and a baby bear while hunting for blueberries with their mothers one bright summer day. All the color and flavor of the sea and pine-covered Maine countryside."—School Library Journal, starred review.




No More Noisy Nights


Book Description

Who is making so much noise and how will Jackson ever get to sleep? Despite some silly, sleepy mistakes, genteel Jackson finds a fun and quiet activity for each of his noisy neighbors. He finally gets a great night's sleep—and discovers three new friends in the morning. Cozier than a mole in fuzzy pajamas, No More Noisy Nights is an underground, under-the covers read-aloud, perfect for calming bedtime boogety-woogeties.




Becoming: Adapted for Young Readers


Book Description

#1 NEW YORK TIMES BESTSELLER • Michelle Obama’s worldwide bestselling memoir, Becoming, is now adapted for young readers. Michelle Robinson was born on the South Side of Chicago. From her modest beginnings, she would become Michelle Obama, the inspiring and powerful First Lady of the United States, when her husband, Barack Obama, was elected the forty-fourth president. They would be the first Black First Family in the White House and serve the country for two terms. Growing up, Michelle and her older brother, Craig, shared a bedroom in their family’s upstairs apartment in her great-aunt’s house. Her parents, Fraser and Marian, poured their love and energy into their children. Michelle’s beloved dad taught his kids to work hard, keep their word, and remember to laugh. Her mom showed them how to think for themselves, use their voice, and be unafraid. But life soon took her far from home. With determination, carefully made plans, and the desire to achieve, Michelle was eager to expand the sphere of her life from her schooling in Chicago. She went to Princeton University, where she learned what it felt like to be the only Black woman in the room. She then went to Harvard Law School, and after graduating returned to Chicago and became a high-powered lawyer. Her plans changed, however, when she met and fell in love with Barack Obama. From her early years of marriage, and the struggle to balance being a working woman, a wife, and the mom of two daughters, Michelle Obama details the shift she made to political life and what her family endured as a result of her husband’s fast-moving political career and campaign for the presidency. She shares the glamour of ball gowns and world travel, and the difficulties of comforting families after tragedies. She managed to be there for her daughters’ swim competitions and attend plays at their schools without catching the spotlight, while defining and championing numerous initiatives, especially those geared toward kids, during her time as First Lady. Most important, this volume for young people is an honest and fascinating account of Michelle Obama’s life led by example. She shares her views on how all young people can help themselves as well as help others, no matter their status in life. She asks readers to realize that no one is perfect, and that the process of becoming is what matters, as finding yourself is ever evolving. In telling her story with boldness, she asks young readers: Who are you, and what do you want to become?