Author : National Library of Medicine (U.S.)
Publisher :
Page : 1170 pages
File Size : 46,80 MB
Release : 1971
Category : Medicine
ISBN :
First multi-year cumulation covers six years: 1965-70.
Author : Aamir Ahmad
Publisher : Springer
Page : 236 pages
File Size : 19,19 MB
Release : 2015-12-14
Category : Medical
ISBN : 3319242237
This, the first of two volumes on personalized medicine in lung cancer, touches on the core issues related to the understanding of lung cancer—statistics and epidemiology of lung cancer—along with the incidence of lung cancer in non-smokers. A major focus of this volume is the state of current therapies against lung cancer—immune, targeted therapies against EGFR TKIs, KRAS, ALK, angiogenesis; the associated challenges, especially resistance mechanisms; and recent progress in targeted drug development based on metal chemistry. Chapters are written by some of the leading experts in the field, who provide a better understanding of lung cancer, the factors that make it lethal, and current research focused on developing personalized treatment plans. With a unique mix of topics, this volume summarizes the current state-of-knowledge on lung cancer and the available therapies.
Author : Anne Le
Publisher : Springer
Page : 186 pages
File Size : 42,71 MB
Release : 2018-06-26
Category : Medical
ISBN : 331977736X
Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Author :
Publisher :
Page : 1738 pages
File Size : 43,94 MB
Release : 1977
Category : American literature
ISBN :
Author : United States. Public Health Service. Office of the Surgeon General
Publisher :
Page : 728 pages
File Size : 30,36 MB
Release : 2010
Category : Government publications
ISBN :
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author :
Publisher :
Page : 1188 pages
File Size : 25,49 MB
Release : 1977
Category : Libraries
ISBN :
Author : Karger (S.) A.G., Basel
Publisher :
Page : 304 pages
File Size : 42,63 MB
Release : 1972
Category : Publishers' catalogs
ISBN :
Author : National Cancer Institute (U.S.)
Publisher :
Page : 766 pages
File Size : 12,39 MB
Release : 1978
Category : Cancer
ISBN :
Author : N. J. Harper
Publisher : Elsevier
Page : 365 pages
File Size : 39,72 MB
Release : 2013-10-22
Category : Medical
ISBN : 148321513X
Advances in Drug Research, Volume 12 covers articles on advances in drug research. The book presents articles on cyclic nucleotides as targets for drug design; the opposing regulatory roles of cyclic nucleotides in the heart; and the integrated control of trematode diseases. The text also includes articles about the chemical and biological studies on indomethacin, sulindac and their analogs; as well as the pharmacokinetics, pharmacodynamics, toxicity, and the effects of bromocriptine. Toxicologists, pharmacologists, physicians, and drug researchers will find the book invaluable.
Author : Maurizio Balestrino
Publisher : BoD – Books on Demand
Page : 548 pages
File Size : 34,94 MB
Release : 2012-03-16
Category : Medical
ISBN : 9535102907
This book reports innovations in the preclinical study of stroke, including - novel tools and findings in animal models of stroke, - novel biochemical mechanisms through which ischemic damage may be both generated and limited, - novel pathways to neuroprotection. Although hypothermia has been so far the sole "neuroprotection" treatment that has survived the translation from preclinical to clinical studies, progress in both preclinical studies and in the design of clinical trials will hopefully provide more and better treatments for ischemic stroke. This book aims at providing the preclinical scientist with innovative knowledge and tools to investigate novel mechanisms of, and treatments for, ischemic brain damage.
