Diffusion MRI


Book Description

Diffusion MRI remains the most comprehensive reference for understanding this rapidly evolving and powerful technology and is an essential handbook for designing, analyzing, and interpreting diffusion MR experiments. Diffusion imaging provides a unique window on human brain anatomy. This non-invasive technique continues to grow in popularity as a way to study brain pathways that could never before be investigated in vivo. This book covers the fundamental theory of diffusion imaging, discusses its most promising applications to basic and clinical neuroscience, and introduces cutting-edge methodological developments that will shape the field in coming years. Written by leading experts in the field, it places the exciting new results emerging from diffusion imaging in the context of classical anatomical techniques to show where diffusion studies might offer unique insights and where potential limitations lie. - Fully revised and updated edition of the first comprehensive reference on a powerful technique in brain imaging - Covers all aspects of a diffusion MRI study from acquisition through analysis to interpretation, and from fundamental theory to cutting-edge developments - New chapters covering connectomics, advanced diffusion acquisition, artifact removal, and applications to the neonatal brain - Provides practical advice on running an experiment - Includes discussion of applications in psychiatry, neurology, neurosurgery, and basic neuroscience - Full color throughout




Computational Neuroanatomy


Book Description

In Computational Neuroanatomy: Principles and Methods, the path-breaking investigators who founded the field review the principles and key techniques available to begin the creation of anatomically accurate and complete models of the brain. Combining the vast, data-rich field of anatomy with the computational power of novel hardware, software, and computer graphics, these pioneering investigators lead the reader from the subcellular details of dendritic branching and firing to system-level assemblies and models.




Neuroanatomy of Language Regions of the Human Brain


Book Description

Many studies of the neural bases of language processes are now conducted with functional and structural neuroimaging. Research is often compromised because of difficulties in identifying the core structures in the face of the complex morphology of these regions of the brain. Although there are many books on the cognitive aspects of language and also on neurolinguistics and aphasiology, Neuroanatomy of Language Regions of the Human Brain is the first anatomical atlas that focuses on the core regions of the cerebral cortex involved in language processing. This atlas is a richly illustrated guide for scientists interested in the gross morphology of the sulci and gyri of the core language regions, in the cytoarchitecture of the relevant cortical areas, and in the connectivity of these areas. Data from diffusion MRI and resting-state connectivity are integrated iwth critical experimental anatomical data about homologous areas in the macaque monkey to provide the latest information on the connectivity of the language-relevant cortical areas of the brain. Although the anatomical connectivity data from studies on the macaque monkey provide the most detailed information, they are often neglected because of difficulties in interpreting the terminology used and in making the monkey-to-human comparison. This atlas helps investigators interpret this important source of information. Neuroanatomy of Language Regions of the Human Brain will assist investigators of the neural bases of language in increasing the anatomical sophistication of their research adn in evaluating studies of language and the brain. - Abundantly illustrated with photographs, 3-D MRI reconstructions, and sections to represent the morphology of the sulci and gyri in the frontal, temporal, and parietal regions involved in language processing - Photomicrographs showing the cytoarchitecture of cortical areas involved in language processing - Series of coronal, sagittal, and horizontal sections identifying the sulci and gyri to assist language investigators using structural and functional neuroimaging techniques - All images accompanied by brief commentaries to help users navigate the complexities of the anatomy - Integration of data from diffusion MRI and resting-state connectivity with critical experimental anatomical data on the connectivity of homologous areas in the macaque monkey




Statistical and Computational Methods in Brain Image Analysis


Book Description

The massive amount of nonstandard high-dimensional brain imaging data being generated is often difficult to analyze using current techniques. This challenge in brain image analysis requires new computational approaches and solutions. But none of the research papers or books in the field describe the quantitative techniques with detailed illustrations of actual imaging data and computer codes. Using MATLAB® and case study data sets, Statistical and Computational Methods in Brain Image Analysis is the first book to explicitly explain how to perform statistical analysis on brain imaging data. The book focuses on methodological issues in analyzing structural brain imaging modalities such as MRI and DTI. Real imaging applications and examples elucidate the concepts and methods. In addition, most of the brain imaging data sets and MATLAB codes are available on the author’s website. By supplying the data and codes, this book enables researchers to start their statistical analyses immediately. Also suitable for graduate students, it provides an understanding of the various statistical and computational methodologies used in the field as well as important and technically challenging topics.




Experimental Neuroanatomy


Book Description

A practical guide to the most important and up-to-date techniques used in experimental neuroanatomy. It should be of use to anyone wishing to apply these important techniques, especially neuroscientists and neuroanatomists.




Neuroanatomical Research Techniques


Book Description

Neuroanatomical Research Techniques discusses developments in major neuroanatomical research techniques. The book is organized into four parts. Part I deals generally with the preparation and study of brain tissue. It includes a chapter on the microscope, discussing optical magnification, limitations of microscopy, and optical contrasting methods. Other chapters summarize basic techniques for tissue preparation and sectioning; present guidelines for a number of standard, but essential, staining procedures; and present sophisticated and contemporary computer techniques that are proving to be invaluable as neuroanatomy evolves from a qualitative to a quantitative discipline. Part II deals with techniques often used for the study of normal tissue. These include the Golgi method, fluorescence histochemistry, techniques for staining single neurons, and the use of the electron microscope. Part III presents techniques for studying intrinsic connections of the nervous system. These include techniques for silver impregnation of degenerating fibers; autoradiographic technique for studying axonal projections; and somatopetal movement of horseradish peroxidase as a tool for studying connections and neuron morphology. Part IV discusses the interpretation of results from neuroanatomical research techniques and presents examples of the applications of neuroanatomical methods to major problems in physiological psychology.




The Neurobiological Basis of Suicide


Book Description

With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.




Neuroanatomy: Draw It to Know It


Book Description

"If you can't draw it, you don't know it:" that was the rule of the late neuroanatomist William DeMyer, MD. Yet books do not encourage us to draw and redraw neuroanatomy. Neuroanatomy: Draw It to Know It teaches neuroanatomy through step-by-step instruction of how to draw neuroanatomical pathways and structures. Its instructive language is highly engaging. Users draw neuroanatomical structures and pathways in several steps so they are remembered and use mental and physical mnemonics to demonstrate difficult anatomical rotations and directional pathways. Anatomical pictures and radiographic images accompany the diagrams to clarify spatially challenging features; relevant synonyms are listed to avoid inter-text confusion; inconsistencies in the neuroanatomy literature are highlighted to mitigate frustration; and historical and current accounts of neuroanatomical systems are presented for perspective. Many neuroanatomy textbooks are great references, but fail to provide a working knowledge of neuroanatomy, and many neuroanatomy handbooks provide bedside pearls, but are too concise to be fully satisfactory. This instructional workbook teaches a comprehensive, but practical approach to neuroanatomy; it includes references where necessary but steers users toward key clinical features. Most importantly, Neuroanatomy: Draw It to Know It instructs the reader to draw and redraw the anatomy and teaches an active approach to learning.




Human Brain Anatomy in Computerized Images


Book Description

By using non-invasive tomographic scans, modern neuroimaging technologies are revealing the structure of the human brain in unprecedented detail. This spectacular progress, however, poses a critical problem for neuroscientists and for practitioners of brain-related professions: how to find their way in the current tomographic images so as to identify a particular brain site, be it normal or damaged by disease? Prepared by a leading expert in advanced brain-imaging techniques, this unique atlas is a guide to the localization of brain structures that illustrates the wide range of neuroanatomical variation. It is based on the analysis of 29 normal human brains obtained from three-dimensional reconstructions of magnetic resonance scans of living persons. The Second Edition of this atlas offers entirely new images, all from new brain specimens.




Medical Image Computing and Computer-Assisted Intervention - MICCAI'98


Book Description

This book constitutes the refereed proceedings of the First International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI'98, held in Cambridge, MA, USA, in October 1998. The 134 revised papers presented were carefully selected from a total of 243 submissions. The book is divided into topical sections on surgical planning, surgical navigation and measurements, cardiac image analysis, medical robotic systems, surgical systems and simulators, segmentation, computational neuroanatomy, biomechanics, detection in medical images, data acquisition and processing, neurosurgery and neuroscience, shape analysis, feature extraction, registration, and ultrasound.