Research Division Report
Author : National Endowment for the Arts. Research Division
Publisher :
Page : pages
File Size : 18,83 MB
Release : 19??
Category : Arts
ISBN :
Author : National Endowment for the Arts. Research Division
Publisher :
Page : pages
File Size : 18,83 MB
Release : 19??
Category : Arts
ISBN :
Author :
Publisher :
Page : 730 pages
File Size : 12,47 MB
Release : 1976
Category : Arts
ISBN :
Author :
Publisher :
Page : 0 pages
File Size : 45,35 MB
Release : 1976
Category : Arts
ISBN :
Author :
Publisher :
Page : 74 pages
File Size : 37,24 MB
Release : 2004
Category : Arts surveys
ISBN :
Author : Lawrence Berkeley Laboratory. Materials and Molecular Research Division
Publisher :
Page : 340 pages
File Size : 38,2 MB
Release : 1986
Category : Materials
ISBN :
Author : Argonne National Laboratory. Radiological and Environmental Research Division
Publisher :
Page : 200 pages
File Size : 50,74 MB
Release : 1973
Category : Ecology
ISBN :
Author : Air Force Human Resources Laboratory. Training Research Division
Publisher :
Page : 212 pages
File Size : 49,64 MB
Release : 1969
Category : Flight training
ISBN :
Author : Frederick Ernest Giesecke
Publisher :
Page : 18 pages
File Size : 19,18 MB
Release : 1922
Category : Engineering
ISBN :
Author : National Research Council
Publisher : National Academies Press
Page : 163 pages
File Size : 22,52 MB
Release : 2010-12-21
Category : Medical
ISBN : 030918651X
Randomized clinical trials are the primary tool for evaluating new medical interventions. Randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors among the participants. Unfortunately, these studies often lack a substantial percentage of data. This missing data reduces the benefit provided by the randomization and introduces potential biases in the comparison of the treatment groups. Missing data can arise for a variety of reasons, including the inability or unwillingness of participants to meet appointments for evaluation. And in some studies, some or all of data collection ceases when participants discontinue study treatment. Existing guidelines for the design and conduct of clinical trials, and the analysis of the resulting data, provide only limited advice on how to handle missing data. Thus, approaches to the analysis of data with an appreciable amount of missing values tend to be ad hoc and variable. The Prevention and Treatment of Missing Data in Clinical Trials concludes that a more principled approach to design and analysis in the presence of missing data is both needed and possible. Such an approach needs to focus on two critical elements: (1) careful design and conduct to limit the amount and impact of missing data and (2) analysis that makes full use of information on all randomized participants and is based on careful attention to the assumptions about the nature of the missing data underlying estimates of treatment effects. In addition to the highest priority recommendations, the book offers more detailed recommendations on the conduct of clinical trials and techniques for analysis of trial data.
Author :
Publisher :
Page : 70 pages
File Size : 10,24 MB
Release : 1984
Category :
ISBN :