Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc


Book Description

This volume is the newest release in the authoritative series issued by the National Academy of Sciences on dietary reference intakes (DRIs). This series provides recommended intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for individuals based on age and gender. In addition, a new reference intake, the Tolerable Upper Intake Level (UL), has also been established to assist an individual in knowing how much is "too much" of a nutrient. Based on the Institute of Medicine's review of the scientific literature regarding dietary micronutrients, recommendations have been formulated regarding vitamins A and K, iron, iodine, chromium, copper, manganese, molybdenum, zinc, and other potentially beneficial trace elements such as boron to determine the roles, if any, they play in health. The book also: Reviews selected components of food that may influence the bioavailability of these compounds. Develops estimates of dietary intake of these compounds that are compatible with good nutrition throughout the life span and that may decrease risk of chronic disease where data indicate they play a role. Determines Tolerable Upper Intake levels for each nutrient reviewed where adequate scientific data are available in specific population subgroups. Identifies research needed to improve knowledge of the role of these micronutrients in human health. This book will be important to professionals in nutrition research and education.




Review of Dietary Advice on Vitamin A


Book Description

This report reassess the dietary advice to consumers on foods and supplements containing Vitamin A (retinol), given evidence from the National Diet and Nutrition Survey that the dietary intake for some adults might exceed the safety guidance level set by the Expert Group on Vitamins and Minerals (EVM) in 2003. Liver and dietary supplements (including fish liver oils) are the main sources of retinol. The report concludes that there is insufficient evidence on the association between high intakes of retinol and poor bone health to justify a change in dietary advice for all consumers, but as a precaution for those who are regular consumers of liver (once a week or more) it may be advisable to avoid supplements containing retinol. People at risk of osteoporosis (such as postmenopausal women and older people) are also advised to limit their retinol intakes. Further research is needed on the relationship between retinol intake and bone fracture risk.




The Vitamin A Story


Book Description

This book shows how vitamin A deficiency – before the vitamin was known to scientists – affected millions of people throughout history. It is a story of sailors and soldiers, penniless mothers, orphaned infants, and young children left susceptible to blindness and fatal infections. We also glimpse the fortunate ones who, with ample vitamin A-rich food, escaped this elusive stalker. Why were people going blind and dying? To unravel this puzzle, scientists around the world competed over the course of a century. Their persistent efforts led to the identification of vitamin A and its essential role in health. As a primary focus of today’s international public health efforts, vitamin A has saved hundreds of thousands of lives. But, we discover, they could save many more were it not for obstacles erected by political and ideological zealots who lack a historical perspective of the problem. Although exhaustively researched and documented, this book is written for intellectually curious lay readers as well as for specialists. Public health professionals, nutritionists, and historians of science and medicine have much to learn from this book about the cultural and scientific origins of their disciplines. Likewise, readers interested in military and cultural history will learn about the interaction of health, society, science, and politics. The author’s presentation of vitamin A deficiency is likely to become a classic case study of health disparities in the past as well as the present.




Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids


Book Description

This volume is the newest release in the authoritative series of quantitative estimates of nutrient intakes to be used for planning and assessing diets for healthy people. Dietary Reference Intakes (DRIs) is the newest framework for an expanded approach developed by U.S. and Canadian scientists. This book discusses in detail the role of vitamin C, vitamin E, selenium, and the carotenoids in human physiology and health. For each nutrient the committee presents what is known about how it functions in the human body, which factors may affect how it works, and how the nutrient may be related to chronic disease. Dietary Reference Intakes provides reference intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for different groups based on age and gender, along with a new reference intake, the Tolerable Upper Intake Level (UL), designed to assist an individual in knowing how much is "too much" of a nutrient.




Prevention of Micronutrient Deficiencies


Book Description

Micronutrient malnutrition affects approximately 2 billion people worldwide. The adverse effects of micronutrient deficiencies are profound and include premature death, poor health, blindness, growth stunting, mental retardation, learning disabilities, and low work capacity. Preventing Micronutrient Deficiencies provides a conceptual framework based on past experience that will allow funders to tailor programs to existing regional/country capabilities and to incorporate within these programs the capacity to address multiple strategies (i.e., supplementation/fortification/food-based approaches/public health measures) and multiple micronutrient deficiencies. The book does not offer recommendations on how to alleviate specific micronutrient deficienciesâ€"such recommendations are already available through the publications of diverse organizations, including the U.S. Agency for International Development, the Micronutrient Initiative, World Bank, United Nations Childrens' Fund, and the World Health Organization. Instead, this volume examines key elements in the design and implementation of micronutrient interventions, including such issues as: The importance of iron, vitamin A, and iodine to health. Populations at risk for micronutrient deficiency. Options for successful interventions and their cost. The feasibility of involving societal sectors in the planning and implementation of interventions. Characteristics of successful interventions. The book also contains three in-depth background papers that address the prevention of deficiencies of iron, vitamin A, and iodine.




Military Strategies for Sustainment of Nutrition and Immune Function in the Field


Book Description

Every aspect of immune function and host defense is dependent upon a proper supply and balance of nutrients. Severe malnutrition can cause significant alteration in immune response, but even subclinical deficits may be associated with an impaired immune response, and an increased risk of infection. Infectious diseases have accounted for more off-duty days during major wars than combat wounds or nonbattle injuries. Combined stressors may reduce the normal ability of soldiers to resist pathogens, increase their susceptibility to biological warfare agents, and reduce the effectiveness of vaccines intended to protect them. There is also a concern with the inappropriate use of dietary supplements. This book, one of a series, examines the impact of various types of stressors and the role of specific dietary nutrients in maintaining immune function of military personnel in the field. It reviews the impact of compromised nutrition status on immune function; the interaction of health, exercise, and stress (both physical and psychological) in immune function; and the role of nutritional supplements and newer biotechnology methods reported to enhance immune function. The first part of the book contains the committee's workshop summary and evaluation of ongoing research by Army scientists on immune status in special forces troops, responses to the Army's questions, conclusions, and recommendations. The rest of the book contains papers contributed by workshop speakers, grouped under such broad topics as an introduction to what is known about immune function, the assessment of immune function, the effect of nutrition, and the relation between the many and varied stresses encountered by military personnel and their effect on health.




Requirements of Vitamin A, Thiamine, Riboflavine and Niacin


Book Description

The prevalence of deficiency states in respect to vitamin A, thiamine, riboflavine, and niacin is discussed in light of clinical evidence. Information on the intake, absorption and utilization of the vitamins and depletion-repletion study results provide a basis to recommend vitamin needs. Specific characteristics, utilization and needs for each vitamin are presented. Practical implications are discussed with reference to 1) assessment of the adequacy of total food supplies and results of consumption surveys; 2) methods of improving diets to attain recommended intake levels; 3) public health aspects of meeting needs of vulnerable groups. The FAO report recommends 1) further research to fill gaps in present knowledge of vitamins; 2) acceptance of recommended intake levels as objectives for nutritional improvement; 3) attention to young children's vulnerability to deficiencies, especially vitamin A; 4) direct attention to adequate nutrient intake for all age group; 5) depreciation of programs that overemphasize provision of individual nutrients rather than balanced intake.




Review of dietary advice on vitamin A


Book Description

This report reassess the dietary advice to consumers on foods and supplements containing Vitamin A (retinol), given evidence from the National Diet and Nutrition Survey that the dietary intake for some adults might exceed the safety guidance level set by the Expert Group on Vitamins and Minerals (EVM) in 2003. Liver and dietary supplements (including fish liver oils) are the main sources of retinol. The report concludes that there is insufficient evidence on the association between high intakes of retinol and poor bone health to justify a change in dietary advice for all consumers, but as a precaution for those who are regular consumers of liver (once a week or more) it may be advisable to avoid supplements containing retinol. People at risk of osteoporosis (such as postmenopausal women and older people) are also advised to limit their retinol intakes. Further research is needed on the relationship between retinol intake and bone fracture risk.




Dietary Reference Intakes Research Synthesis


Book Description

What information is available to inform the planning of a nutrition research agenda for the United States and Canada? This question provided the backdrop for the Dietary Reference Intakes Research Synthesis project undertaken by the Food and Nutrition Board of the Institute of Medicine (IOM) of the National Academies. The Dietary Reference Intakes (DRIs) are quantitative reference values for recommended intakes and tolerable upper intake levels for a range of nutrients. They are used widely by dietitians in individual counseling, by federal nutrition officials in program and policy development, and by the nutrition research and education communities in government, academia, and industry. Between 1997 and 2005, the IOM published a series of six DRI reports covering a total of 45 nutrients, energy, and other food components. The IOM also issued two reports describing ways to apply the DRIs in assessment and planning. Together, these eight reports contain more than 450 research recommendations and thus a wealth of information pertinent to a nutrition research agenda. To make the recommendations more accessible, the Food and Nutrition Board undertook a project with two major elements: (1) the development of a searchable database of all the DRI research recommendations, and (2) the Dietary Reference Intakes Research Synthesis Workshop, held June 7-8, 2006, which was designed to provide a venue for hearing and discussing experts' perspectives on the research recommendations identified in the DRI reports. Two members of the workshop planning group-Drs. John W. Suttie and Susan J. Whiting-moderated the DRI Research Synthesis Workshop. After an overview and demonstration of the DRI Research Synthesis Database, panels of experts addressed DRI research recommendations related to each of the six DRI nutrient reports, the two DRI applications reports, and three cross-cutting topics: (1) setting DRIs for children, (2) Tolerable Upper Intake Levels, and (3) relevant new and underutilized research techniques. This report is a summary of the workshop presentations and discussions.




Drug-Induced Liver Injury


Book Description

Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series