Revisiting Barrett's Esophagus


Book Description

This book focuses on Barrett’s Esophagus (BE), a clinical condition that must be evaluated in all patients affected by chronic GERD, and with an important link to esophageal cancer. Divided into four sections (morphological background, epidemiology and natural history, diagnosis, and treatments), this handy volume provides the latest indications regarding endoscopic approaches (first level and advanced endoscopy), pathological studies (pathology and molecular biology), and state-of-the-art therapeutic options (medical, endoscopic, and surgical) for BE. As such, it offers a valuable reference guide for all professionals involved in the management of BE (gastroenterologists, endoscopists, pathologists and surgeons), offering them a comprehensive overview and deeper understanding of this seemingly superficial disease.




Dropping Acid


Book Description

Dropping Acid: The Reflux Diet Cookbook & Cure is the first book to explain how acid reflux, particularly silent reflux, is related to dietary and lifestyle factors. It also explains how and why the reflux epidemic is related to the use of acid as a food preservative. Dr. Koufman defines the symptoms this shockingly common disease and explains why a change in diet can alleviate some of the most common symptoms. Dropping Acid offers a dietary cure for acid reflux, as well as lists of the best and worst foods for a reflux sufferer. The book’s recipes use tasty fats as flavorings, not as main ingredients; included are the recipes for tasty dishes that prove living with reflux doesn't mean living without delicious food.




Barrett's Esophagus


Book Description

This 6th volume of OESO has the advantage to address a topic which is at the forefront of concern for all those involved with disease of the upper digestive tract: an entity inserted in the epidemiological sequence of GERD, a benign affection among the most widespread in the world, Barrett's esophagus, has become today a problem of Public Health. Its recognised propensity to degenerate has, in fact, made it one of the benign lesions of the upper digestive tract which legitimately arouses the convergent interest of clinicians, as well as those devoted to fundamental research. Large scale epidemiological studies, the development of even sharper means for early detection of the precursory signs of its degeneration, the extreme diversity of the treatments available today, all lend new perspectives to the different centres of interest of this book.




NADPH Oxidases Revisited: From Function to Structure


Book Description

This book provides a unique, comprehensive, and up-to-date overview of the various NADPH oxidases and narrates the history of their discovery, biochemical characteristics, genetics, molecular structure, and multiple functions in health and disease. It covers the subject in a manner that serves both the expert and the novice researcher in the field. The book starts with an overview of the major milestones in the discovery of the archetypical NADPH oxidase, known as cytochrome b558, and its cytosolic regulators. This is followed by personal recollections by pioneers of the field, descriptions of the work of the major figures of the past by their followers, and a rendering of the history of the discovery of the Nox family. The central section of the book consists of chapters devoted specifically to an in depth description of the individual members of the Nox family, and is followed by chapters focused on the modulators of their function. A subsequent section comprises chapters dealing with methodologies of Nox research, interaction with other proteins, and Nox inhibitors. A distinct section of the book deals with non-mammalian Noxs, from amoeba to zebrafish. Subsequent chapters focus on Nox structure, a field in which extraordinary progress was made in recent years. The volume ends with chapters on Chronic Granulomatous Disease, the consequence of Nox loss-of-function, and its treatment by gene therapy. The coda is a crystal ball perspective of the hopes for the clinical translation of basic Nox research. Written for biochemists, cell biologists, molecular biologists, and clinicians, this book is aimed at both senior scientists and young investigators in the field.




The Esophagus


Book Description

THE ESOPHAGUS The Esophagus investigates the anatomy, physiology, and pathology of the esophagus. This sixth edition, revised and updated throughout, also explores the diagnosis and treatment of various esophageal conditions. It includes treatment guidelines approved by the two largest gastroenterology societies, the ACG and AGA, as befits a work co-edited by two former presidents of those organizations. Advancements in diagnostics are presented, as are developments in the surgical and drug therapies. Presented in full colour, and boasting an unrivalled team of editors and contributing authors, The Esophagus Sixth Edition will find a home wherever the anatomy, physiology, and pathology of the esophagus are studied and taught. This book is accompanied by a website containing all the figures from the book in PowerPoint format. www.wiley.com/go/richter/esophagus6e Praise for the Fifth Edition: “There is absolutely no doubt that this edition of the textbook will maintain its status as the go-to reference for esophageal conditions, and will remain a highly utilized and clinically useful resource for novice and experienced physicians and surgeons alike.” (Gastroenterology, 1 July 2013)




Cancer Precursor Conditions and their Detection, An Issue of Hematology/Oncology Clinics of North America


Book Description

In this issue of Hematology/Oncology Clinics, guest editor Dr. Elizabeth K. O'Donnell brings her considerable expertise to the topic of Cancer Precursor Syndromes and Their Detection. Top experts focus on cancer precursors for different sites, with articles on the risk-benefit analysis of early interception; plasma cell precursors; early detection and interception of lung cancer, cervical cancer, GI cancers, skin cancer; and head and neck cancer; biomarkers and early detection; and more. - Contains 12 relevant, practice-oriented topics including clonal hematopoiesis of indeterminate potential (CHIP); prostate cancer: early detection and intervention; ductal carcinoma in situ; cancer prevention; and more. - Provides in-depth clinical reviews on cancer precursor syndromes and their detection, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.




Shackelford's Surgery of the Alimentary Tract, E-Book


Book Description

For more than 60 years, Shackelford's Surgery of the Alimentary Tract has served as the cornerstone reference in this fast-moving field. With comprehensive coverage of all aspects of GI surgery, the 8th Edition, by Drs. Charles J. Yeo, Steven R. DeMeester, David W. McFadden, Jeffrey B. Matthews, and James W. Fleshman, offers lavishly illustrated, authoritative guidance on endoscopic, robotic, and minimally invasive procedures, as well as current medical therapies. Each section is edited by a premier authority in GI surgery; chapters reflect key topics and are written by a "who's who" of international experts in the field. It's your one-stop resource for proven, systematic approaches to all relevant adult and pediatric GI disorders and operations - Features an abundance of beautifully detailed intraoperative and laparoscopic photographs, as well as radiographs and line drawings, to enhance and clarify the text. - Presents essential information, such as lists of differential diagnoses, in tabular format for quick reference. - Discusses recent, major advances in minimally invasive surgery and robotic surgery, personalized therapy based on genomics and proteomics, and new pharmacologic treatments of various GI diseases. - Includes all-new information on laparoscopy for rectal cancer, sacral nerve stimulation for incontinence and constipation, management of Crohn's disease and ulcerative colitis, advances in immunosuppression for transplant patients, and new therapies for inflammatory bowel disease. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.




Barrett's Esophagus and Esophageal Adenocarcinoma


Book Description

The leading reference text entirely devoted to this increasinglysignificant condition This text is dedicated to Barrett’s esophagus and providesrecent evidence and current approaches to patient management. Ithas been completely revised, updated and extended to include thelatest research findings and describes how these affect day-to-dayclinical practice. It includes seven new chapters and even more color images thanthe last edition. Each chapter, written by the leadinginternational experts in the field, provides clear, didacticguidance on diagnosis, treatment and management of thiscondition. Barrett’s Espohagus gives an extensive overviewcovering epidemiology, screening, pathology, gastroenterology andsurgery. It looks at the precursor lesions leading to thedevelopment of Barrett’s epithelium, the uniquecharacteristics of Barrett’s esophagus, and the consequencesof malignant degeneration. All aspects of diagnosis, secondaryprevention, multimodality, and medical and surgical treatment areclearly explained. This is a complete guide on the latest thinking on diagnosis andtreatment of Barrett’s esophagus which can be referred toover and over again.




Esophageal Cancer and Barrett's Esophagus


Book Description

Esophageal Cancer and Barrett’s Esophagus, 3E, focuses on these two common and key conditions that affect the esophagus, providing expert guidance to their pathogenesis, cause, prevention, diagnosis and clinical management. Top international names in the field examine each of the many issues involved, using the very latest evidence-based research, and clear, didactic advice allows the reader to understand the best methods of diagnosis and clinical management of each condition – whether early or late stage. Well-illustrated and fully revised to include the latest in ACG/ASG/UEGW guidelines, it is the perfect consultation tool for gastroenterologists and oncologists managing patients with cancer of the esophagus. It is also ideal for teaching residents and fellows optimum patient management, and for identifying areas requiring future research.




New Directions in Barrett's Esophagus, An Issue of Gastrointestinal Endoscopy Clinics


Book Description

Dr. Shaheen's issue of Gastrointestinal Endoscopy Clinics of North America addresses the current thinking and clinical decision making surrounding endoscopy for Barrett's Esophagus. Expert authors have contributed articles on the following topics: The Troublesome Epidemiology of Barrett’s Esophagus and Esophageal Adenocarcinoma; Who Deserves Endoscopic Screening for Esophageal Neoplasia; Alternatives to Traditional per oral Endoscopy for Screening; Effectiveness and Cost-Effectiveness of Endoscopic Screening and Surveillance; The Role of Adjunct Imaging in Endoscopic Detection of Dysplasia; Beyond Dysplasia Grade: The Role of Biomarkers in Stratifying Risk; Management of Nodular Neoplasia in Barrett’s Esophagus: Endoscopic Mucosal Resection and Endoscopic Submucosal Dissection; EUS and Management of Superficial Esophageal Neoplasia; Radiofrequency Ablation of Barrett’s Esophagus: Patient Selection, Preparation, and Performance; Radiofrequency Ablation of Barrett’s Esophagus: Efficacy, Complications, and Durability; Cryotherapy of Barrett’s Esophagus; Care of the Post-Ablation Patient: Surveillance, Acid Suppression and Treatment of Recurrence; and Surgical Management of Superficial Esophageal Neoplasia. Readers will come away with the knowledge to diagnose and treat neoplasia and Barrett's Esophagus using the latest techniques.