Rifkind's Challenge


Book Description

Rifkind, a warrior sorceress in a barbarian world, seeks her fate as the true-born Daughter of the Bright Moon in this standalone follow-up to The Black Flame. In a desert world ruled by men, Rifkind has always been one apart. A chieftain's daughter, she learned to wield a sword while all other women were bound by tribal custom to children and the cooking fire. But when her clan was massacred, she set forth on a quest for her destiny in savage lands ruled by magic and the sword. For a while she had thought that she had found a home. She practiced the healing arts and raised her son. But now she has once again heard a personal call to arms, a call to leave behind the safety of her home. She will once again take up the way of the sword, the way of sorcery. And this time she is not alone. At the Publisher's request, this title is being sold without Digital Rights Management Software (DRM) applied.




The Alzheimer's Disease Challenge


Book Description

Alzheimer’s disease is undoubtedly the major health challenge of our Century with significant social and economic consequences. This Frontiers eBook offers a contribution of 39 innovative papers on the multidimensional and crucial problem of Alzheimer’s disease management and treatment. Several perspectives, research updates, and trials describing methods on potential diagnosis and treatment are presented including biological mechanisms, biomarkers and risk factors for an early and efficient prognosis, diagnosis and prevention. Additionally, while the rapidly increasing Alzheimer’s disease population demands holistic solutions and clinical studies with new therapeutic target approaches, several of the contributive papers present promising drugs targeting Alzheimer’s disease treatment. We give our deepest acknowledgment to all the authors for their important and innovative contributions, to the reviewers for their valuable recommendations on improving the submitting studies and all the Frontiers Editorial team for continuous support.




Teaching Politics and International Relations


Book Description

A state of the discipline approach to teaching and learning in Politics and IR including contributions which discuss the most cutting-edge approaches, techniques, and methodologies for tutors. This book discusses the themes and challenges in teaching and learning whilst also exploring these in the specific context of political science and IR.




Bioactive Natural Products


Book Description

Bioactive natural products are a rich source of novel therapeutics. Thus, the search for bioactive molecules from nature continues to play an important role in fashioning new medicinal agents. This volume, which comprises sixteen chapters written by active researchers and leading experts in natural products chemistry, brings together an overview of current discoveries in this remarkable field. It also provides information on the industrial application of natural products for medicinal purposes. This book will serve as a valuable resource for researchers to predict promising leads for developing pharmaceuticals to treat various ailments and disease manifestations.




Against Decolonisation


Book Description

Decolonisation has lost its way. Originally a struggle to escape the West’s direct political and economic control, it has become a catch-all idea, often for performing ‘morality’ or ‘authenticity’; it suffocates African thought and denies African agency. Olúfẹ́mi Táíwò fiercely rejects the indiscriminate application of ‘decolonisation’ to everything from literature, language and philosophy to sociology, psychology and medicine. He argues that the decolonisation industry, obsessed with cataloguing wrongs, is seriously harming scholarship on and in Africa. He finds ‘decolonisation’ of culture intellectually unsound and wholly unrealistic, conflating modernity with coloniality, and groundlessly advocating an open-ended undoing of global society’s foundations. Worst of all, today’s movement attacks its own cause: ‘decolonisers’ themselves are disregarding, infantilising and imposing values on contemporary African thinkers. This powerful, much-needed intervention questions whether today’s ‘decolonisation’ truly serves African empowerment. Táíwò’s is a bold challenge to respect African intellectuals as innovative adaptors, appropriators and synthesisers of ideas they have always seen as universally relevant.




Cross-Talk and Interaction between Endocrinology and Urology: Challenges and Opportunities


Book Description

The genitourinary system is closely related to the endocrine system. Some genitourinary organs are endocrine organs themselves. Over the past decades, the diagnosis and treatment on both endocrine and urological diseases have developed rapidly. Concerns regarding the normal growth, development, and physiological functions of the genitourinary system, as well as the pathogenesis and treatment of urinary diseases have been raised. The diseases from these two different systems belong to the specialties of internal medicine and surgery respectively. For example, prostate is regulated by androgen originates from testis, adrenal and even malignancies. Androgen deprivation therapy has definite effect on prostatic adenocarcinoma but may also develop castration resistance. The disorders of gonad and reproductive health are also implicated in hormone regulation, such as delayed hypogonadism. Many diseases such as Cushing's syndrome and aldosteronism are transdisciplinary. However, the research on the normal physiological function, and the comprehensive diagnosis and treatment of both systems are short of cross-integration, resulting in a lack of close cooperation between physicians and surgeons. We are calling for more attention on the joint participation in multidisciplinary diagnosis and treatment, as well as collaboration on basic research in the field of genitourinary and endocrine diseases.




Current Challenges in Personalized Cancer Medicine


Book Description

For this volume of Advances in Pharmacology we have brought together some of the foremost basic science and clinical researchers to discuss some of the new frontiers in the development of targeted cancer therapy. Although still in its formative stages, the development of targeted cancer therapies has already shown incredible promise in a limited number of cancer types. As basic cancer research and drug development continues, we expect this number to grow and more patients to benefit from these exciting advances. Through better patient selection and novel strategies to manage resistance, a future can be envisaged in which cancer can be reduced to the level of a chronic, manageable disease. Brought together some of the foremost basic science and clinical researchers Part of the renowned Advances in Pharmacology Serial Discussion of some of the new frontiers in the development of targeted cancer therapy







NK Cells in Cancer Immunotherapy: Successes and Challenges


Book Description

NK Cells in Cancer Immunotherapy: Successes and Challenges explains the latest immunotherapeutic strategies, focusing on NK cells to allow the best and precise combination treatments to cancer patients. The book provides existing background knowledge in the field of immunotherapy and discusses future areas of research required to carry out cutting-edge, validated therapies. Chapters cover advances in immunotherapeutic strategies, in particular, the use of NK cells with and without T-cell therapy in the treatment of cancer. The book is a valuable resource for cancer researchers, oncologists, graduate students and those interested in learning more about novel strategies to treat cancer patients. Immunotherapy is fast becoming the method of choice for cancer therapy. Although remarkable advances have been made in the field of immunotherapy, there are significant challenges and difficulties ahead since many of the current immunotherapeutic strategies do not provide long-lasting treatment strategies, and therefore are not very effective. - Covers CAR/T and CAR/NK and adoptive NK cell therapy with and without T cell therapies - Discusses basic biology of NK cells and mouse models of human cancers and the role of NK cells in metastatic cancer and in cancer stem cells - Encompasses information on combination therapies using check point inhibition, adoptive transfer of cytotoxic effector cells, chemotherapeutic drugs and activating and inhibitory antibodies




Challenges of Information Technology Education in the 21st Century


Book Description

Challenges of Information Technology Education in the 21st Century strives to address a variety of pertinent questions surrounding the rapidly changing area of IT education, such as: What topics are important for the 21st Century? How does the Internet change the task of teaching? What is the role of the professor in a world of online learning? This exciting book will be an invaluable resource for educators in the field of information technology.