Statistical Methods for QTL Mapping


Book Description

While numerous advanced statistical approaches have recently been developed for quantitative trait loci (QTL) mapping, the methods are scattered throughout the literature. Statistical Methods for QTL Mapping brings together many recent statistical techniques that address the data complexity of QTL mapping. After introducing basic genetics topics and statistical principles, the author discusses the principles of quantitative genetics, general statistical issues of QTL mapping, commonly used one-dimensional QTL mapping approaches, and multiple interval mapping methods. He then explains how to use a feature selection approach to tackle a QTL mapping problem with dense markers. The book also provides comprehensive coverage of Bayesian models and MCMC algorithms and describes methods for multi-trait QTL mapping and eQTL mapping, including meta-trait methods and multivariate sequential procedures. This book emphasizes the modern statistical methodology for QTL mapping as well as the statistical issues that arise during this process. It gives the necessary biological background for statisticians without training in genetics and, likewise, covers statistical thinking and principles for geneticists. Written primarily for geneticists and statisticians specializing in QTL mapping, the book can also be used as a supplement in graduate courses or for self-study by PhD students working on QTL mapping projects.










Guidelines for the Seismic Evaluation and Upgrade of Water Transmission Facilities


Book Description

Prepared by the Technical Council on Lifeline Earthquake Engineering of ASCE This TCLEE Monograph provides guidelines for the seismic evaluation and upgrade of water transmission facilities, including aqueducts, tunnels, canals, buried pipelines, elevated pipelines and their appurtenances. Topics covered include the performance of these facilities in past earthquakes; geotechnical issues; performance criteria; risk analysis; analysis methods; and a series of case studies. The guidelines can also be used for the design of new water transmission facilities. The case studies cover seismic designs and retrofits for the Mokelumne Aqueduct, the Contra Costa Canal, the Borel Canal, buried pipes at fault crossings, and auxiliary water fire fighting systems. The case studies also examine post-earthquake operations, financial issues, and the benefits of seismic retrofits.




Library of Congress Subject Headings


Book Description




Guidelines for Design of Low-Rise Buildings Subjected to Lateral Forces


Book Description

Guidelines for Design of Low-Rise Buildings Subjected to Lateral Forces is a concise guide that identifies performance issues, concerns, and research needs associated with low-rise buildings. The book begins with an introduction that discusses special problems with low-rise buildings subjected to wind and earthquakes. Chapter 2 examines probabilistic methods and their use in evaluating risks from natural hazards. It also addresses the characteristics of wind and seismic forces and levels of risk implied by building codes. Wind forces are covered in more detail in Chapter 3, with discussions of wind force concepts and wind-structure interactions. Chapter 4 is devoted to earthquake forces and traces the development of building codes for earthquake resistant design. Chapter 5 describes the main framing systems used to resist lateral forces and discusses the code requirements for drift control. The designs and requirements for connections between building elements are addressed in Chapter 6. It includes examples along with several illustrations of suitable connections. The performance of non-structural elements during wind and earthquake forces is also examined in detail. This book serves as an important reference for civil engineers, construction engineers, architects, and anyone concerned with structural codes and standards. It is an excellent guide that can be used to supplement design recommendations and provide a design basis where there are no current requirements.