Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research


Book Description

The marmoset, a type of small monkey native to South America, is a research model of increasing importance for biomedical research in the United States and globally. Marmosets offer a range of advantages as animal models in neuroscience, aging, infectious diseases, and other fields of study. They may be particularly useful for the development of new disease models using genetic engineering and assisted reproductive technologies. However, concerns have been voiced with respect to the development of new marmoset-based models of disease, ethical considerations for their use, the supply of marmosets available for research, and gaps in guidance for their care and management. To explore and address these concerns, the Roundtable on Science and Welfare in Laboratory Animal Use hosted a public workshop on October 22-23, 2018, in Washington, DC. The workshop focused on the availability of marmosets in the United States and abroad; animal welfare and ethical considerations stemming from the use of wildtype and genetically modified marmosets; and standards of housing and care, dietary needs, and feeding requirements for marmosets in captivity. This publication summarizes the presentations and discussions from the workshop.




The Common Marmoset in Captivity and Biomedical Research


Book Description

The Common Marmoset in Captivity and Biomedical Research is the first text dedicated exclusively to this species,filling an urgent need for an encyclopedic compilation of the existing information. Sponsored by the AmericanCollege of Laboratory Animal Medicine as part of its authoritative Blue Book series, the book covers the biology,management, diseases, and clinical and research applications of this important species. The common marmoset(Callithrix jacchus) has come of age in the scientific community as a behaviorally complex, cognitively advanced,small, prolific, and easily maintained nonhuman primate with many of the advantages of larger animals, such asmacaques, but without the attendant physical and zoonotic risks. Marmosets are currently being used in diverse areas of inquiry, including vision and auditory research, infectious disease, cognitive neuroscience, behavior, reproductive biology, toxicology and drug development, and aging. Themarmoset genome has been sequenced and there is currently an intensive effort to apply gene editing technologies to the species. The creation of transgenic marmosets will provide researchers with a small nonhuman primatemodel to study a number of poorly understood disorders, like autism. Presents a complete view of the marmoset, covering their biology and management, diseases and clinical applications, and research applications Includes contributions from renowned and international authors and editors Provides the first authoritative and comprehensive treatment of marmosets in biomedical research as part of the ACLAM Series




The Smallest Anthropoids


Book Description

Here is a comprehensive examination of the newly recognized callimico/marmoset clade, which includes the smallest anthropoid primates on earth. It features sections on phylogeny, taxonomy and functional anatomy, behavioral ecology, and reproductive physiology.




Adaptive Radiations of Neotropical Primates


Book Description

This collection of 29 papers grew out of a symposium entitled "Setting the Future Agenda for Neotropical Primates. " The symposium was held at the Department of Zoo logical Research, National Zoological Park, Washington D. C. , on February 26-27, 1994, and was sponsored by the Wenner-Gren Foundation for Anthropological Research, Smith sonian Institution, and Friends of the National Zoo. We put the symposium together with two objectives: to honor Warren G. Kinzey for his contributions to the growing field of platyrrhine studies and to provide researchers who work in the Neotropics with the oppor tunity to discuss recent developments, to identify areas of research that require additional study, and especially to help guide the next generation of researchers. The symposium provided the opportunity to recognize Warren as a mentor and col laborator to the contribution of the study of platyrrhines. Contributions to the book were expanded in order to provide a more comprehensive view of platyrrhine evolution and ecology, to emphasize the interdisciplinary nature of many of these studies, and to high light the central role that New World monkeys play in advancing primatology. If this vol ume were to require major revisions after just one more decade of research, that would be a fitting testament to Warren's enthusiasm and his drive to continually update the field with new ideas and methods. Tributes to Warren and a list of his publications have been published elsewhere (Norconk, 1994, 1996; Rosenberger 1994, 1995).




The Cambridge Handbook of Animal Cognition


Book Description

This handbook lays out the science behind how animals think, remember, create, calculate, and remember. It provides concise overviews on major areas of study such as animal communication and language, memory and recall, social cognition, social learning and teaching, numerical and quantitative abilities, as well as innovation and problem solving. The chapters also explore more nuanced topics in greater detail, showing how the research was conducted and how it can be used for further study. The authors range from academics working in renowned university departments to those from research institutions and practitioners in zoos. The volume encompasses a wide variety of species, ensuring the breadth of the field is explored.




Mammalian Sexuality


Book Description

The first detailed account of post-copulatory sexual selection and the evolution of reproduction in mammals.




Primate Social Systems


Book Description

This book grew from small beginnings as I began to find unexpected patterns emerging from the data in the literature. The more I thought about the way in which primate social systems worked, the more interesting things turned out to be. I am conscious that, at times, this has introduced a certain amount of complexity into the text. I make no apologies for that: what we are dealing with is a complex subject, the product of evolutionary forces interacting with very sophisticated minds. None the less, I have done my best to explain every thing as clearly as I can in order to make the book accessible to as wide an audience as possible. I have laid a heavy emphasis in this book on the use of simple graphical and mathematical models. Their sophistication, however, is not great and does not assume more than a knowledge of elementary probability theory. Since their role will inevitably be misunderstood, I take this opportunity to stress that their function is essentially heuristic rather than explanatory: they are designed to focus our attention on the key issues so as to point out the directions for further research. A model is only as good as the questions it prompts us to ask. For those whose natural inclination is to dismiss modelling out of hand, I can only point to the precision that their use can offer us in terms of hypothesis-testing.