Author : Amin Tamadon
Publisher : Frontiers Media SA
Page : 137 pages
File Size : 44,36 MB
Release : 2022-03-16
Category : Science
ISBN : 288974471X
Author : Prashant Kesharwani
Publisher : Elsevier
Page : 896 pages
File Size : 44,18 MB
Release : 2024-10-10
Category : Science
ISBN : 044322045X
Theranostics Nanomaterials in Drug Delivery presents the most recent advances in the development of theranostic nanomaterials for drug delivery. This book compiles reports and studies on the latest changes and improvements of theranostic nanocarriers such as nanoemulsions, liposomes, exosomes, polymeric micelles, PLGA nanoparticles, chitosan nanoparticles, dendrimer, quantum dots, silica nanoparticles, gold nanoparticles, silver nanoparticles, magnetic nanoparticles, and many more, all of which can help in the sensitive diagnosis, precise targeting, and efficient and controlled delivery of nanomaterials to control various diseases at different clinical stages. Theranostics nanomaterials in drug delivery will serve as a solid foundation and reference for pharmaceutical scientists, undergraduate and postgraduate students, researchers, and experts in the medical field involved in the development of advanced drug delivery systems. - Presents a compilation of thoroughly analyzed data and results regarding the usage of theranostics nanocarriers as a platform for diagnosis and treatment of various diseases - Gathers novel drug delivery applications of theranostics nanocarriers in biological milieu and discusses the principles behind the formation, characterization, applications, and future perspectives of theranostics for targeted therapy development - Discusses the most recent technologies in theranostics nanometrials to help readers define major gaps in knowledge that can lead new scientific breakthroughs and discoveries
Author : Maulin P. Shah
Publisher : Elsevier
Page : 290 pages
File Size : 31,47 MB
Release : 2024-05-16
Category : Technology & Engineering
ISBN : 0443135320
Microbial Metagenomics in Effluent Treatment Plant introduces a metagenomic approach characterizing microbial communities?in industrial wastewater treatment, providing an overall picture of metagenomics, its application, processes, and future prospects in the field of bioremediation. It also discusses culture-dependent methods, culture-independent methods, and?enzymatic methods?used to estimate bacterial diversity to monitor temporal and spatial changes in bacterial communities. In addition, a metagenomic approach will be discussed to characterize the microbial communities in industrial wastewater treatment. Researchers, scientists, professors, and students in environmental engineering, applied microbiology, and water treatment will find Microbial Metagenomics in Effluent Treatment Plant helpful in understanding the importance and role of metagenomics in biogeochemical cycles and degradation and detoxification of environmental pollutants. - Presents text rich in information and knowledge of metagenomics - Introduces novel and powerful insights into the already existing bioremediation process - Serves as an easy-to-understand and centralized resource of information with practical application ideas
Author : Fernando Rodrigues
Publisher : Frontiers Media SA
Page : 164 pages
File Size : 27,61 MB
Release : 2021-06-23
Category : Science
ISBN : 2889668894
Author : James J. O'Donnell
Publisher : CRC Press
Page : 899 pages
File Size : 46,60 MB
Release : 2019-12-13
Category : Medical
ISBN : 1351625136
Drug Discovery and Development, Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted trends are also provided. Features: Highlights emerging scientific fields relevant to drug discovery such as the microbiome, nanotechnology, and cancer immunotherapy; and novel research tools such as CRISPR and DNA-encoded libraries Case study detailing the discovery of the anti-cancer drug, lorlatinib Venture capitalist commentary on trends and best practices in drug discovery and development Comprehensive review of regulations and their impact on drug development, highlighting special populations, orphan drugs, and pharmaceutical compounding Multidiscipline functioning of an Academic Research Enterprise, plus a chapter on Ethical Concerns in Research Contributions by 70+ experts from industry and academia specialists who developed and are practitioners of the science and business
Author : Carolyn A. Staton
Publisher : John Wiley & Sons
Page : 410 pages
File Size : 33,22 MB
Release : 2007-01-11
Category : Medical
ISBN : 047002934X
Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and the full range of effects of a given test protein. Although the endothelial cell - its migration, proliferation, differentiation and structural rearrangement - is central to the angiogenic process, it is not the only cell type involved. the supporting cells, the extracellular matrix and the circulating blood with its cellular and humoral components also contribute. In this book, experts in the use of a diverse range of assays outline key components of these and give a critical appraisal of their strengths and weaknesses. Examples include assays for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures, assessment of endothelial and mural cell interactions, and such in vivo assays as the chick chorioallantoic membrane, zebrafish, corneal, chamber and tumour angiogenesis models. These are followed by a critical analysis of the biological end-points currently being used in clinical trials to assess the clinical efficacy of anti-angiogenic drugs, which leads into a discussion of the direction future studies should take. This valuable book is of interest to research scientists currently working on angiogenesis in both the academic community and in the biotechnology and pharmaceutical industries. Relevant disciplines include cell and molecular biology, oncology, cardiovascular research, biotechnology, pharmacology, pathology and physiology.
Author :
Publisher : Academic Press
Page : 224 pages
File Size : 30,69 MB
Release : 2018-06-23
Category : Medical
ISBN : 0128141700
Advances in Cancer Research, Volume 139, provides invaluable information on the exciting and fast-moving field of cancer research. Original reviews are presented on a variety of topics relating to the rapidly developing intersection between nanotechnology and cancer research, with unique sections in the new release focusing on Exosomes as a theranostic for lung cancer, Nanotechnology and cancer immunotherapy, Ultrasound imaging agents and delivery systems, Dendronized systems for the delivery of chemotherapeutics, Thermosensitive liposomes for image-guided drug delivery, Supramolecular Chemistry in Tumor Analysis and Drug Delivery, Gold nanoparticles for delivery of cancer therapeutics, and Single cell barcode microchip for cancer research and therapy. - Provides the latest information on cancer research - Offers outstanding and original reviews on a range of cancer research topics - Serves as an indispensable reference for researchers and students alike
Author : Deborah Elstein
Publisher : Springer Science & Business Media
Page : 525 pages
File Size : 11,31 MB
Release : 2010-08-02
Category : Medical
ISBN : 9048190339
Fabry disease is an X-linked inborn error of metabolism wherein deficiency of a lysosomal enzyme results in systemic deposition of glycosphingolipids. Storage deposition, and hence pathological disease, occurs preferentially in renal glomerular and tubular epithelial cells, myocardial cells, heart valve fibrocytes, neurons of dorsal root ganglia, and in endothelial smooth muscle cells of blood vessels. Thus, Fabry disease is a multi-system disorder, albeit with considerable phenotypic heterogeneity in onset and in severity; however, it is progressive, exhibits extensive morbidity, and is life-threatening. Within the past two decades, there has been a radical change in the natural course Fabry disease by virtue of the availability of specific enzyme replacement therapy. Moreover, there has been a concerted effort to better understand the underlying pathology and equally to identify patients prior to the onset of irreversible end-organ damage. It is to be hoped that the future for patients with Fabry disease can be viewed with greater, albeit guarded, optimism. This state-of-the-art textbook attempts to bridge the span of pre-clinical studies, clinical finding, and management options in a readable but comprehensive manner for the medical practitioner as well as the interested non-medical reader.
Author : Padma V. Devarajan
Publisher : Springer Nature
Page : 564 pages
File Size : 36,90 MB
Release : 2019-11-09
Category : Medical
ISBN : 3030291685
This book elaborates on drug delivery targeting via intracellular delivery, specifically through the Receptor Mediated Endocytosis (RME) approach, due to the involvement of cellular receptors in various grave diseases. Targeted delivery relies on two basic approaches, passive and active targeting. While passive targeting approaches have shown great promise, the improved selectivity achieved with active targeting approaches has resulted in significantly higher efficacy. Interestingly there are numerous strategies for active targeting, many of which are already highlighted in , Targeted Drug Delivery: Concepts and Applications. Nevertheless an exciting and practical strategy for active targeting, which could enable high intracellular delivery, is through exploitation of RME. Cells in the body express receptors to enable various physiological and biochemical processes. As a result, many of these receptors are overexpressed in pathological conditions, or newer receptors expressed due to defective cellular functioning. RME is based on exploitation of such receptors to achieve intracellular delivery. While targeted delivery can have manifold applications, in this book we focus on two major and challenging therapeutic areas; i) Cancer and ii) Infectious Diseases. Targeted Intracellular Drug Delivery by Receptor Medicated Endocytosis discusses the major receptors that are useful for targeted delivery for these afflictions. A major section of this book is dedicated to details regarding their occurrence and location, the recognition domain of the receptor, structure activity relationship of substrate /ligand for selective binding, ligands explored, antagonists for ligand binding and relevance of these aspects for therapy of cancer and infectious diseases. These facets are elucidated with the help of specific examples from academic research and also emphasize commercial products, wherever relevant. In vitro cellular models relied on for assessing receptor mediated cellular targeting and in vivo models depicting clinical efficacy are focused on in a separate section. Finally, we briefly discuss the regulatory and toxicity issues that may be associated specifically with the RME approach of intracellular drug delivery.
Author : Sauro Longhi
Publisher : Springer Nature
Page : 218 pages
File Size : 17,77 MB
Release : 2020-01-03
Category : Science
ISBN : 3030338797
The book describes significant multidisciplinary research findings at the Università Politecnica delle Marche and the expected future advances. It addresses some of the most dramatic challenges posed by today’s fast-growing, global society and the changes it has caused, while also discussing solutions to improve the wellbeing of human beings. The book covers the main research achievements made in the social sciences and humanities, and includes chapters that focus on understanding mechanisms that are relevant to all aspects of economic and social interactions among individuals. In line with Giorgio Fuà’s contribution, the interdisciplinary research being pursued at the Faculty of Economics of Università Politecnica delle Marche is aimed at interpreting the process of economic development in all of its facets, both at the national and local level, with a particular focus on profit and non-profit organizations. Various disciplines are covered, from economics to sociology, history, statistics, mathematics, law, accounting, finance and management.
