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Tantalizing Therapeutics in Bronchopulmonary Dysplasia

Author : Vineet Bhandari

Publisher : Academic Press

Page : 258 pages

File Size : 25,97 MB

Release : 2020-06-02

Category : Medical

ISBN : 0128189916

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Book Description

Tantalizing Therapeutics in Bronchopulmonary Dysplasia is a concise reference that provides an overview of emerging concepts in the understanding of lung development and injury from a molecular and cellular point-of-view, including exciting pathways that are paving the way for new options to prevent or treat Bronchopulmonary Dysplasia (BPD). The book's chapters are written by experts who are at the forefront of BPD research. Coverage includes chapters on exosomes, stem cells and miRs, as well as a section on new discoveries in BPD research with translational potential. This is a must-have reference for researchers, physicians and trainees working on BPD, lung developmental biology, and more. - Includes discussions on which aspects of the bench research in Bronchopulmonary Dysplasia are the most promising areas - Offers insights into the latest research being conducted that could potentially move to the bassinet (in the NICU) - Contains evidence-based summaries and informed opinions about existing therapies





Targeted Molecular Imaging in Oncology

Author : E. Edmund Kim

Publisher : Springer Science & Business Media

Page : 322 pages

File Size : 31,77 MB

Release : 2001

Category : Medical

ISBN : 9780387950280

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Book Description

Cancer cells dedifferentiate with repect to cell function; their vascularity is more leaky, but perfusion is heterogenerously reduced, and interstitial fluid pressure is high, severely retarding delivery of agents from the blood. Targeted imaging is designed to produce a detectable difference between tissue that is visualized with single photon and positron emission tomography, magnetic resonance imaging, computed tomography, or ultrasonography. This book uniquely reports strategies for the application of molecular targeted imaging agents such as antibodies, peptides, receptors and contrast agents in the biologic grading of tumors, differential diagnosis of tumors, prediction of therapeutic response and monitoring tumor response to treatment. This book also describes updated information about the imaging of tumor angiogenesis, hypoxia, apoptosis and gene delivery as well as expression in the understanding and utility of tumor molecular biology for better cancer management.



The Newborn Lung

Author : Eduardo Bancalari

Publisher : Elsevier Health Sciences

Page : 419 pages

File Size : 16,85 MB

Release : 2018-06-19

Category : Medical

ISBN : 0323568750

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Book Description

Dr. Richard Polin's Neonatology Questions and Controversies series highlights the most challenging aspects of neonatal care, offering trustworthy guidance on up-to-date diagnostic and treatment options in the field. In each volume, renowned experts address the clinical problems of greatest concern to today's practitioners, helping you handle difficult practice issues and provide optimal, evidence-based care to every patient. - Stay fully up to date in this fast-changing field with The Newborn Lung, 3rd Edition. - The most current clinical information throughout, including key management strategies that may reduce some of the chronic sequelae of neonatal respiratory failure. - New content on the role of microbiome in lung injury and lung development. - Current coverage of non-invasive respiratory support, perinatal events and their influence on lung development and injury, cell-based lung therapy, automation of respiratory support, and oxygenation targeting in preterm infants. - Consistent chapter organization to help you find information quickly and easily. - The most authoritative advice available from world-class neonatologists who share their knowledge of new trends and developments in neonatal care. Purchase each volume individually, or get the entire 7-volume set!Gastroenterology and NutritionHematology, Immunology and GeneticsHemodynamics and CardiologyInfectious Disease and Pharmacology New Volume!Nephrology and Fluid/Electrolyte PhysiologyNeurologyThe Newborn Lung



Magnetic Resonance Elastography

Author : Sudhakar K. Venkatesh

Publisher : Springer

Page : 143 pages

File Size : 40,52 MB

Release : 2014-10-01

Category : Medical

ISBN : 1493915754

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Book Description

The first book to cover the groundbreaking development and clinical applications of Magnetic Resonance Elastography, this book is essential for all practitioners interested in this revolutionary diagnostic modality. The book is divided into three sections. The first covers the history of MRE. The second covers technique and clinical applications of MRE in the liver with respect to fibrosis, liver masses, and other diseases. Case descriptions are presented to give the reader a hands-on approach. The final section presents the techniques, sequence and preliminary results of applications in other areas of the body including muscle, brain, lung, heart, and breast.



Diseases of the Newborn

Author : Alexander J. Schaffer

Publisher : W.B. Saunders Company

Page : 1388 pages

File Size : 20,29 MB

Release : 1977

Category : Medical

ISBN :

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Book Description

Over 9000 English-language entries to medical terminology, with etymology given in Japanese and English. Entries include word in English; part of speech; Greek, Latin, or other roots; and elements of word.



Epigenetic Biomarkers and Diagnostics

Author : Jose Luis Garcia-Gimenez

Publisher : Academic Press

Page : 698 pages

File Size : 34,68 MB

Release : 2015-12-07

Category : Science

ISBN : 0128019212

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Book Description

Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease. - Focuses on recent progress in several areas of epigenetics, general concepts regarding epigenetics, and the future prospects of this discipline in clinical diagnostics and prognostics - Describes the importance of the quality of samples and clinical associated data, and also the ethical issues for epigenetic diagnostics - Discusses the advances in epigenomics technologies, including next-generation sequencing based tools and applications - Expounds on the utility of epigenetic biomarkers for diagnosis and prognosis of several diseases, highlighting the study of these biomarkers in cancer, cardiovascular and metabolic diseases, infertility, and infectious diseases - Includes a special section that discusses the relevance of biobanks in the maintenance of high quality biosamples and clinical-associated data, and the relevance of the ethical aspects in epigenetic studies



Fetal & Neonatal Secrets

Author : Richard Polin

Publisher : Elsevier Health Sciences

Page : 578 pages

File Size : 47,76 MB

Release : 2013-10-01

Category : Medical

ISBN : 0323172865

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Book Description

Fetal and Neonatal Secrets by Drs. Richard Polin and Alan Spitzer, uses the success formula of the highly popular Secrets Series to offer fast answers to the most essential clinical questions in fetal and neonatal medicine. With its user-friendly Q&A format, practical tips from neonatologists and fetal medicine experts, and "Key Points" boxes, this portable and easy-to-read medical reference book provides rapid access to the practical knowledge you need to succeed both in practice and on board and recertification exams. "Fetal and Neonatal Secrets is a book with an alternative setup that offers answers to a wide spectrum of clinical questions in the field of fetal and neonatal medicine. The book covers both fetal and neonatal medicine, and could be relevant for junior doctors aiming to become obstetricians or pediatricians." Reviewed by: Acta Obstetricia et Gynecologica Scandinavica, January 2015 - Get the evidence-based guidance you need to provide optimal care for your fetal and neonatal patients. - Zero in on key fetal and neonatal information with a question and answer format, bulleted lists, mnemonics, and practical tips from the authors. - Enhance your reference power with a two-color page layout, "Key Points" boxes, and lists of useful websites. - Review essential material efficiently with the "Top 100 Secrets in Fetal and Neonatal Medicine" – perfect for last-minute study or self-assessment. - Apply all the latest pediatric advances in clinical fetal neonatology techniques, technology, and pharmacology



Transporters in Drug Discovery and Development

Author : Yurong Lai

Publisher : Woodhead Publishing

Page : 759 pages

File Size : 29,90 MB

Release : 2014-08-22

Category : Science

ISBN : 190881828X

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Book Description

Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery and developments. - A comprehensive overview of drug transporter families and their clinical relevance in drug discovery and development - Balanced coverage of molecular biology aspects and functional outcomes - State of art knowledge related to transporter-mediated DDI and the clinical relevance in pharmacokinetics, dynamics, and toxicity



Diagnostic and Therapeutic Antibodies

Author : Andrew J.T. George

Publisher : Humana

Page : 0 pages

File Size : 33,63 MB

Release : 2010-11-09

Category : Medical

ISBN : 9781617371950

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Book Description

Soon after the first description of monoclonal antibodies in 1976, there was enormous interest in the clinical application of antibodies, especially in the context of cancer. Antibodies appeared to offer the “magic bullet” that would allow the specific destruction of neoplastic cells. H- ever, many years’ effort resulted in very few cases of successful immu- therapy with antibodies. As a result there was a major backlash against antibody therapy, and the field lost a considerable amount of popularity. Fashion, in science as well as in other things, tends to be cyclical. Antibody-based therapy is once again attracting scientists and clinicians. There are several reasons for the renewed optimism; certainly the expe- ence of the last two decades has provided a wealth of information about problems associated with antibody therapy, and possible solutions to these problems. Recombinant antibody engineering has rejuvenated the field, allowing both the modification of antibodies to improve their in vivo pr- erties and the isolation of novel antibody molecules by such techniques as phage display. The results of recent clinical trials have demonstrated unequivocally the benefit of antibody therapy in a number of settings, and, finally, more careful consideration has been taken of the types of disease best treated using this approach.