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Targeting Angiogenesis, Inflammation and Oxidative Stress in Chronic Diseases

Author : Tapan Behl

Publisher : Elsevier

Page : 524 pages

File Size : 30,84 MB

Release : 2024-01-26

Category : Computers

ISBN : 0443135886

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Book Description

Targeting Angiogenesis, Inflammation and Oxidative Stress in Chronic Diseases presents recent advances in the vivid molecular pathways targeting angiogenesis, inflammation and oxidative stress that contribute very widely to the genesis of chronic diseases. The books will also highlight the drugs from natural and synthetic origin in the management/prevention/treatment of diseases along with the drug delivery approaches. The book’s authors from various key institutions around the globe will deliver well-structured and well-designed chapters. The systematic presented information and knowledge will surely aid consistency and continuity. The multifaceted book is enriched with deep scientific contents. Each chapter will clearly define the facts, emerging role of molecular pathways and the targets and focus will be imparted on key challenges associated and the future directions that will provide torch bearer thing for the researchers to explore new targets in the domain. Focuses on the pathogenesis of the disease, along with the molecular mechanism of action Includes updates on strategic design/delivery of drugs targeting angiogenesis, inflammation, and oxidative stress Provides recent advancements in the field of pathogenesis of chronic diseases



Oxidative Stress and Signal Transduction

Author : H.J. Forman

Publisher : Springer Science & Business Media

Page : 484 pages

File Size : 12,32 MB

Release : 2012-12-06

Category : Science

ISBN : 1461559812

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Book Description

In the past few years there has been the increased recognition that the effects of oxidative stress are not limited to the damage of cellular constituents. There is now evidence that reactive oxygen species (ROS) can alter cell function by acting upon the intermediates, or second messengers, in signal transductions. Such effects on signaling mechanisms probably account for the role of oxidative stress in inflammation, aging, and cancer. This volume brings together internationally recognized researchers in both the major areas covered by the book, oxidative stress and signal transduction. The work is organized in three sections. The first deals with the immediate cellular responses to oxidative stress and the production of second messengers. The second details the connection between second messengers and the gene. The third part looks more closely at the level of the gene.



Angiogenesis in Adipose Tissue

Author : Yihai Cao

Publisher : Springer Science & Business Media

Page : 374 pages

File Size : 47,47 MB

Release : 2013-09-05

Category : Medical

ISBN : 1461480698

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Book Description

Angiogenesis has recently played a critical role in regulation of adipose tissue expansion and regression. Like most other tissues in the body, adipose expansion and regression is accompanied by alteration of blood vessel density and structures. The vascular alteration plays an active role in regulation of adipose tissue size and functions. Targeting blood vessels in the adipose tissue have demonstrated to be a novel approach for possibly treatment of cancer, obesity and other metabolic diseases. This book provides the most updated information on this type research and discusses future opportunities for therapy..



Macrophages in Liver Disease

Author : Ruchi Bansal

Publisher : Frontiers Media SA

Page : 178 pages

File Size : 30,79 MB

Release : 2020-10-08

Category : Medical

ISBN : 2889660389

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Book Description

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.



The immunological regulation of extracellular vesicles on chronic diseases

Author : Zhiwen Luo

Publisher : Frontiers Media SA

Page : 146 pages

File Size : 20,14 MB

Release : 2024-06-26

Category : Medical

ISBN : 2832550800

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Book Description

With the transformation of the human disease spectrum, chronic non-infectious diseases have become the main killer of human health in modern society. The interaction between genes and the environment will cause the body’s immune function to be disordered, thereby affecting the body's homeostasis and causing various chronic non-infectious diseases. It has been revealed that the occurrence and development of most chronic diseases, such as cancer, cardiac disease, diabetes mellitus, autoimmune disease, and neuroimmune disorders, are associated with the dysregulation of the immune system.



Systems Biology of Free Radicals and Antioxidants

Author : Ismail Laher

Publisher : Springer

Page : 0 pages

File Size : 24,1 MB

Release : 2014-06-16

Category : Medical

ISBN : 9783642300172

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Book Description

The focus of this collection of illustrated reviews is to discuss the systems biology of free radicals and anti-oxidants. Free radical induced cellular damage in a variety of tissues and organs is reviewed, with detailed discussion of molecular and cellular mechanisms. The collection is aimed at those new to the field, as well as clinicians and scientists with long standing interests in free radical biology. A feature of this collection is that the material also brings insights into various diseases where free radicals are thought to play a role. There is extensive discussion of the success and limitations of the use of antioxidants in several clinical settings.



Angiogenesis Assays

Author : Carolyn A. Staton

Publisher : John Wiley & Sons

Page : 410 pages

File Size : 22,64 MB

Release : 2007-01-11

Category : Medical

ISBN : 047002934X

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Book Description

Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and the full range of effects of a given test protein. Although the endothelial cell - its migration, proliferation, differentiation and structural rearrangement - is central to the angiogenic process, it is not the only cell type involved. the supporting cells, the extracellular matrix and the circulating blood with its cellular and humoral components also contribute. In this book, experts in the use of a diverse range of assays outline key components of these and give a critical appraisal of their strengths and weaknesses. Examples include assays for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures, assessment of endothelial and mural cell interactions, and such in vivo assays as the chick chorioallantoic membrane, zebrafish, corneal, chamber and tumour angiogenesis models. These are followed by a critical analysis of the biological end-points currently being used in clinical trials to assess the clinical efficacy of anti-angiogenic drugs, which leads into a discussion of the direction future studies should take. This valuable book is of interest to research scientists currently working on angiogenesis in both the academic community and in the biotechnology and pharmaceutical industries. Relevant disciplines include cell and molecular biology, oncology, cardiovascular research, biotechnology, pharmacology, pathology and physiology.



Oxidative Stress and Vascular Disease

Author : John F. Keaney Jr.

Publisher : Springer Science & Business Media

Page : 404 pages

File Size : 20,80 MB

Release : 1999-12-31

Category : Medical

ISBN : 9780792386780

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Book Description

One of the major biomedical triumphs of the post-World War II era was the defmitive demonstration that hypercholesterolemia is a key causative factor in atherosclerosis; that hypercholesterolemia can be effectively treated; and that treatment significantly reduces not only coronary disease mortality but also all cause mortality. Treatment to lower plasma levels of cholesterol - primarily low density lipoprotein (LDL) cholesterol - is now accepted as best medical practice and both physicians and patients are being educated to take aggressive measures to lower LDL. We can confidently look forward to important decreases in the toll of coronary artery disease over the coming decades. However, there is still uncertainty as to the exact mechanisms by which elevated plasma cholesterol and LDL levels initiate and favor the progression of lesions. There is general consensus that one of the earliest responses to hypercholesterolemia is the adhesion of monocytes to aortic endothelial cells followed by their penetration into the subendothelial space, where they differentiate into macrophages. These cells, and also medial smooth muscle cells that have migrated into the subendothelial space, then become loaded with mUltiple, large droplets of cholesterol esters . . . the hallmark of the earliest visible atherosclerotic lesion, the so-called fatty streak. This lesion is the precursor of the more advanced lesions, both in animal models and in humans. Thus the centrality of hypercholesterolemia cannot be overstated. Still, the atherogenic process is complex and evolves over a long period of time.



Plant-derived Bioactives

Author : Mallappa Kumara Swamy

Publisher : Springer Nature

Page : 619 pages

File Size : 38,19 MB

Release : 2020-05-11

Category : Science

ISBN : 9811517614

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Book Description

Plants produce a vast number of bioactive compounds with different chemical scaffolds, which modulate a diverse range of molecular targets and are used as drugs for treating numerous diseases. Most present-day medicines are derived either from plant compounds or their derivatives, and plant compounds continue to offer limitless reserves for the discovery of new medicines. While different classes of plant compounds, like phenolics, flavonoids, saponins and alkaloids, and their potential pharmacological applications are currently being explored, their curative mechanisms are yet to be understood in detail. This book is divided into 2 volumes and offers detailed information on plant-derived bioactive compounds, including recent research findings. Volume 1, Plant-derived Bioactives: Chemistry and Mode of Action, discusses the chemistry of highly valued plant bioactive compounds and their mode of actions at the molecular level. Volume 2, Plant-derived Bioactives: Production, Properties and Therapeutic Applications, explores the sources, biosynthesis, production, biological properties and therapeutic applications of plant bioactives. Given their scope, these books are valuable resources for members of the scientific community wishing to further explore various medicinal plants and the therapeutic applications of their bioactive compounds. They appeal to scholars, teachers and scientists involved in plant product research, and facilitate the development of innovative new drugs.



Oxidative Stress, Inflammation and Angiogenesis in the Metabolic Syndrome

Author : Raquel Soares

Publisher : Springer Science & Business Media

Page : 213 pages

File Size : 23,81 MB

Release : 2009-02-25

Category : Medical

ISBN : 1402097018

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Book Description

Metabolic Syndrome (MS) is a highly prevalent condition in developed countries and is a cluster of several risk factors for type 2 diabetes and cardiovascular disease that includes increased body mass index/waist circumference, visceral obesity, insulin resistance, hyperclycaemia, dyslipidaemia and hypertension, which are all major causes of morbidity and death. This volume provides a critical review and discussion of the knowledge gathered on MS and analyzes the interplay between oxidative stress, chronic inflammation and angiogenesis features. There is a special focus on recent discoveries and progress toward possible therapeutic strategies, such as the role of glucose transporters within MS; the effects of polyphenols as anti-oxidant, anti-inflammatory and anti-angiogenic compounds. The role of NFkB, nitric oxide synthases, hypoxia-inducible factors, and many other molecules that play a part in the development of oxidative stress and inflammation as well as angiogenesis is also covered. This book fills the gap between basic science and medical care, and provides the reader with the skills to apply rigorous basic science to clinical settings of metabolic syndrome-associated disorders.