Telomeres and Telomerase in Aging, Disease, and Cancer


Book Description

Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that limit cellular lifespan and survival in response to telomere dysfunction. There is special focus on adult stem cells.




The Telomere Effect


Book Description

The New York Times bestselling book coauthored by the Nobel Prize winner who discovered telomerase and telomeres' role in the aging process and the health psychologist who has done original research into how specific lifestyle and psychological habits can protect telomeres, slowing disease and improving life. Have you wondered why some sixty-year-olds look and feel like forty-year-olds and why some forty-year-olds look and feel like sixty-year-olds? While many factors contribute to aging and illness, Dr. Elizabeth Blackburn discovered a biological indicator called telomerase, the enzyme that replenishes telomeres, which protect our genetic heritage. Dr. Blackburn and Dr. Elissa Epel's research shows that the length and health of one's telomeres are a biological underpinning of the long-hypothesized mind-body connection. They and other scientists have found that changes we can make to our daily habits can protect our telomeres and increase our health spans (the number of years we remain healthy, active, and disease-free). The Telemere Effect reveals how Blackburn and Epel's findings, together with research from colleagues around the world, cumulatively show that sleep quality, exercise, aspects of diet, and even certain chemicals profoundly affect our telomeres, and that chronic stress, negative thoughts, strained relationships, and even the wrong neighborhoods can eat away at them. Drawing from this scientific body of knowledge, they share lists of foods and suggest amounts and types of exercise that are healthy for our telomeres, mind tricks you can use to protect yourself from stress, and information about how to protect your children against developing shorter telomeres, from pregnancy through adolescence. And they describe how we can improve our health spans at the community level, with neighborhoods characterized by trust, green spaces, and safe streets. The Telemere Effect will make you reassess how you live your life on a day-to-day basis. It is the first book to explain how we age at a cellular level and how we can make simple changes to keep our chromosomes and cells healthy, allowing us to stay disease-free longer and live more vital and meaningful lives.




Telomeres and Telomerase in Cancer


Book Description

Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in “cancer stem cells” has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge.




Telomeres and Telomerase


Book Description

Telomeres are essential functional elements of eukaryotic chromosomes. Their fundamental biological role as protectors of chromosome stability was identified for the first time in the 1930s by Hermann Muller and Barbara McClintock based on pioneering cytological experiments. Modern molecular research carried out more recently revealed that telomeres and telomerase play important roles in processes such as carcinogenesis and cellular senescence. This special issue presents the most recent developments in this highly active field of research. It is becoming increasingly clear that molecular pathways involved in regulation of telomere length and structure are functionally linked with pathways involved in DNA damage response, cellular stress response, chromatin organization and perhaps even pathways that regulate evolutionary chromosome rearrangements. The above functional link is explored by the leading experts in the field of telomere biology. Cell biologists, molecular biologists, oncologists, gerontologists, and radiobiologists with an interest in the role of telomeres/telomerase will appreciate the up-to-date information in this publication.




Telomeres, Diet and Human Disease


Book Description

The maintenance of telomeres—repetitive sequences at the end of chromosome—is essential to health. Dysfunction in telomere maintenance pathways plays a role in aging, cancer, atherosclerosis and other diseases. This has led to telomere maintenance as a prime target for patient therapies. This book describes the advances in telomere research as it applies to human health and especially how lifestyle and dietary factors could modify the telomerase maintenance process. The book examines the mechanisms involved, the primary of which are oxidative stress and the role of sirtuins, and how they can be modified by dietary patterns such as Mediterranean diet.




The Telomerase Revolution


Book Description

Science is on the cusp of a revolutionary breakthrough. We now understand more about ageing - and how to prevent and reverse it - than ever before. In The Telomerase Revolution, Dr Michael Fossel, who has been at the cutting edge of ageing research for decades, describes how telomerase will soon be used as a powerful therapeutic tool, with the potential to intervene in age-related disease, dramatically extend life spans and even reverse human ageing. Telomerase-based treatments are already on offer, and have shown early promise, but much more potent treatments will become available over the next decade. This is the definitive work on the latest science of human ageing, covering both the theory and the clinical implications, taking readers to the forefront of one of the most remarkable advances in human medicine.




Telomere Miracle


Book Description

What if everything you think you know about getting older and staying healthy is wrong? Ed Park, M.D., offers the revolutionary idea that disease and aging in humans all arises from a single source: genetic errors caused by shortening of telomeres, or the sequences of DNA at the ends of our chromosomes. Telomeres naturally wear down over time, and thus when cells replicate (as they do all the time in our bodies), they’re creating progressively poorer-quality duplicates of themselves, like making a Xerox of a Xerox of a Xerox. Ultimately, the body deteriorates, resulting in a range of ailments, many of which we associate with aging—from diabetes to hypertension to macular degeneration to cancer. Happily, Ed tells us, it’s possible to slow or even reverse this process and effectively turn back the clock. In The Telomere Miracle, he explains cutting-edge science in a lively style, using illustrations and metaphors ranging from auto parts to superheroes. Then he shows readers how they can intervene in the aging process by boosting the activity of the enzyme telomerase naturally by understanding and optimizing six key areas of breathing, mindset, sleep, exercise, diet, and supplements.




Comprehensive Geriatric Oncology


Book Description

Published in 2004: This new edition of Comprehensive Geriatric Oncology still offers an exhaustive review of the biology of cancer and aging, of the epidemiologic trends in the country and in the world, and of the clinical trials that concern cancer prevention and cancer treatment in the elderly.




Telomere Biology


Book Description

This book extensively discusses the biology of telomere with the help of advanced information. Developments in telomere researches have provided an interrelation of telomere dysfunction with cellular aging and several age-related human diseases. Some new findings and studies have further widened our knowledge of telomere functions, where telomeres have been demonstrated to be essential for microbial pathogen virulence and telomere proteins have significant non-telomeric cellular functions. This book presents current opinions on selected areas of telomere research and their implication, in the hope of benefitting interested individuals in their future studies and enhancing their research progress.




Biochemistry and Cell Biology of Ageing: Part I Biomedical Science


Book Description

This new volume in the Subcellular Biochemistry series will focus on the biochemistry and cellular biology of aging processes in human cells. The chapters will be written by experts in their respective fields and will focus on a number of the current key areas of research in subcellular aging research. Main topics for discussion are mitochondrial aging, protein homeostasis and aging and the genetic processes that are involved in aging. There will also be chapters that are dedicated to the study of the roles of a variety of vitamins and minerals on aging and a number of other external factors (microbiological, ROS, inflammation, nutrition). This book will provide the reader with a state of the art overview of the subcellular aging field. This book will be published in cooperation with a second volume that will discuss the translation of the cell biology of aging to a more clinical setting and it is hoped that the combination of these two volumes will bring a deeper understanding of the links between the cell and the body during aging.