Electrophysiology of the Central Nervous System


Book Description

The most important yet the most difficult scientific task confront ing man is how his brain produces his behavior and his subjective experience. The complexity of this problem is ineffably vast, ex ceeding by many orders of magnitude the theoretical and technical achievements concerning atomic energy or the exploration of space. Unlike these areas of endeavor, neuroscience is fortunate in knowing no national rivalries, and its only secrecies are those of language. The latter, however, are often highly effective in con cealing from workers in Los Angeles the discoveries of their co- leagues in Moscow. A cogent example is provided in this volume by Roy John (p. 179) whose experiments proceeded for several years before he discovered the important body of data accumulated earlier by Prof. Livanov and his colleagues utilizing the same ingenious technique of the "tracer stimulus." Reduction of such occurrences is certainly one of the goals of the present book, which now becomes a double translation, a dozen of the papers having originally been translated into Russian.




Auditory Cortex


Book Description

In recent decades, auditory cortex has taken centre stage in studies of the auditory system and sound perception. Our knowledge of this structure, though still sparse, paints a picture of an extremely complex brain region, probably the most complicated yet in the auditory pathway. This book is a collection of works summarising the latest developments in auditory cortex research and reviews the current state of knowledge about cortical anatomy, function and malfunction. The book highlights use of state-of-the-art technological methodologies in unravelling various facts about auditory cortex. It canvasses findings ranging from intracellular and extracellular electrophysiology, optical imaging, quantitative electroencephalography in addition to reviews of molecular techniques, functional imaging approaches and histological anatomy.




Local Cortical Circuits


Book Description

Neurophysiologists are often accused by colleagues in the physical sci ences of designing experiments without any underlying hypothesis. This impression is attributable to the ease of getting lost in the ever-increasing sea of professional publications which do not state explicitly the ultimate goal of the research. On the other hand, many of the explicit models for brain function in the past were so far removed from experimental reality that they had very little impact on further research. It seems that one needs much intimate experience with the real nerv-. ous system before a reasonable model can be suggested. It would have been impossible for Copernicus to suggest his model of the solar system without the detailed observations and tabulations of star and planet motion accu mulated by the preceeding generations. This need for intimate experience with the nervous system before daring to put forward some hypothesis about its mechanism of action is especially apparent when theorizing about cerebral cortex function. There is widespread agreement that processing of information in the cor tex is associated with complex spatio-temporal patterns of activity. Yet the vast majority of experimental work is based on single neuron recordings or on recordings made with gross electrodes to which tens of thousands of neurons contribute in an unknown fashion. Although these experiments have taught us a great deal about the organization and function of the cor tex, they have not enabled us to examine the spatio-temporal organization of neuronal activity in any detail.




The Mammalian Auditory Pathways


Book Description

The auditory system is a complex neural system composed of many types of neurons connected into networks. One feature that sets the auditory system apart from other sensory systems, such as somatosensory or visual systems, is the many stages of neural processing that occur between the ear in the periphery and the cerebral cortex. Each stage is composed of specialized types of neurons connected in specific microcircuits that perform computations on the information about sound. To understand this processing, all the tools of neuroscience must be employed. The proposed text integrates cell biology, synaptic physiology, and electrophysiology to fully develop the topic, presenting an overview of the functional anatomy of the central auditory system. It is organized based on the neuronal connectivity of the central auditory system, which emphasizes the neurons, their synaptic organization, and their formation of functional pathways and microcircuits. The goal of the book is to stimulate research into the cell biology of the central auditory system and the characteristics of the specific neurons and connections that are necessary for normal hearing. Future research on the development of the central auditory including that employing stem cells will require such information in order to engineer appropriate therapeutic approaches. ​




The Auditory Cortex


Book Description

There has been substantial progress in understanding the contributions of the auditory forebrain to hearing, sound localization, communication, emotive behavior, and cognition. The Auditory Cortex covers the latest knowledge about the auditory forebrain, including the auditory cortex as well as the medial geniculate body in the thalamus. This book will cover all important aspects of the auditory forebrain organization and function, integrating the auditory thalamus and cortex into a smooth, coherent whole. Volume One covers basic auditory neuroscience. It complements The Auditory Cortex, Volume 2: Integrative Neuroscience, which takes a more applied/clinical perspective.




The Cognitive Electrophysiology of Mind and Brain


Book Description

Cognitive electrophysiology is a very well established field utilizing new technologies such as bioelectric events-related potentials (ERP) and magnetic (ERF) recordings to pursue the investigation of mind and brain. Current research focuses on reviewing ERP/ERF findings in the areas of attention, language, memory, visual and auditory perceptual processing, emotions, development, and neuropsychological clinical damages. The goal of such research is basically to provide correlations between the structures of the brain and their complex cognitive functions.This book reviews the latest findings in the areas of attention, language, memory, visual and auditory perception, and brain damage research based primarily on research conducted using ERP recordings. Beyond just compiling the knowledge gained from ongoing research, the authors also identify outstanding problems in the field and predict future developments. - Provides an original post-cognitive theoretical approach to the investigation of the human mind and brain - Presents integrated view of the emotional and cognitive features as well as of developmental features of neurocognitive systems - Well-illustrated with elegant and original artwork that clarifies complex theoretical and methodological points throughout the text




Cognitive Electrophysiology


Book Description

MICHAEL S. GAZZANIGA The investigation of the human brain and mind involves a myriad of ap proaches. Cognitive neuroscience has grown out of the appreciation that these approaches have common goals that are separate from other goals in the neural sciences. By identifying cognition as the construct of interest, cognitive neuro science limits the scope of investigation to higher mental functions, while simultaneously tackling the greatest complexity of creation, the human mind. The chapters of this collection have their common thread in cognitive neuroscience. They attack the major cognitive processes using functional stud ies in humans. Indeed, functional measures of human sensation, perception, and cognition are the keystone of much of the neuroscience of cognitive sci ence, and event-related potentials (ERPs) represent a methodological "coming of age" in the study of the intricate temporal characteristics of cognition. Moreover, as the field of cognitive ERPs has matured, the very nature of physiology has undergone a significant revolution. It is no longer sufficient to describe the physiology of non-human primates; one must consider also the detailed knowledge of human brain function and cognition that is now available from functional studies in humans-including the electrophysiological studies in humans described here. Together with functional imaging of the human brain via positron emission tomography (PET) and functional magnetic resonance imaging (fMRI), ERPs fill our quiver with the arrows required to pierce more than the single neuron, but the networks of cognition.