The Garki Project


Book Description




Ecological Knowledge and Environmental Problem-Solving


Book Description

This volume explores how the scientific tools of ecology can be used more effectively in dealing with a variety of complex environmental problems. Part I discusses the usefulness of such ecological knowledge as population dynamics and interactions, community ecology, life histories, and the impact of various materials and energy sources on the environment. Part II contains 13 original and instructive case studies pertaining to the biological side of environmental problems, which Nature described as "carefully chosen and extremely interesting."




Saving Lives, Buying Time


Book Description

For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.




Some Mathematical Questions in Biology


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Deals with problems in epidemiology, allergic reactions, resource management, and presents a model of respiration




The Development of Modern Epidemiology


Book Description

This book describes the evolution of epidemiology, its methods, concepts and application over the last 100 years. Current and future epidemiologists will find this book a useful and insightful record of the events that have shaped this discipline.




Advances in Disease Vector Research


Book Description

I think the reader will agree that we have attained a good balance in Volume 6 between human-or animal-host and plant-host-related topics from outstanding research scientists. In Chapter 1, Frank Collins, Susan Paskewitz, and Victoria Finnerty explore the potential of recombinant DNA technology to distinguish indi vidual species and to establish phylogenetic relationships among member species in the Anopheles gambiae species complex, which includes the principal malaria vectors. Currently, relatively little is known about these morphologically identical species that are sympatric over most of their range but are not always equally involved in malaria transmission. With respect to individual species identification, the researchers have thus far described two DNA fragments, derived from the ribosomal DNA interge nic spacer region, that reliably distinguish five species in the complex by means of an RFLP visualized on a Southern blot. They have also described other species-specific fragments derived from a ribosomal DNA intron that could form the basis for a rapid dot blot assay. With respect to the phylogenetic relationships among member species in the complex, Collins, Paskewitz, and Finnerty focus on a comparison at the level of restriction site mapping and Southern analysis of the rDNA intergenic spacer regions. As expected, the two spacer regions near the coding region junctions are well conserved among the species, whereas the central regions tend to be highly variable among member species in the complex.




The Making of a Tropical Disease


Book Description

A global history of malaria that traces the natural and social forces that have shaped its spread and made it deadly, while limiting efforts to eliminate it. Malaria sickens hundreds of millions of people—and kills nearly a half a million—each year. Despite massive efforts to eradicate the disease, it remains a major public health problem in poorer tropical regions. But malaria has not always been concentrated in tropical areas. How did malaria disappear from other regions, and why does it persist in the tropics? From Russia to Bengal to Palm Beach, Randall M. Packard's far-ranging narrative shows how the history of malaria has been driven by the interplay of social, biological, economic, and environmental forces. The shifting alignment of these forces has largely determined the social and geographical distribution of the disease, including its initial global expansion, its subsequent retreat to the tropics, and its current persistence. Packard argues that efforts to control and eliminate malaria have often ignored this reality, relying on the use of biotechnologies to fight the disease. Failure to address the forces driving malaria transmission have undermined past control efforts. Describing major changes in both the epidemiology of malaria and efforts to control the disease, the revised edition of this acclaimed history, which was chosen as the 2008 End Malaria Awards Book of the Year in its original printing, • examines recent efforts to eradicate malaria following massive increases in funding and political commitment; • discusses the development of new malaria-fighting biotechnologies, including long-lasting insecticide-treated nets, rapid diagnostic tests, combination artemisinin therapies, and genetically modified mosquitoes; • explores the efficacy of newly developed vaccines; and • explains why eliminating malaria will also require addressing the social forces that drive the disease and building health infrastructures that can identify and treat the last cases of malaria. Authoritative, fascinating, and eye-opening, this short history of malaria concludes with policy recommendations for improving control strategies and saving lives.




Field Trials of Health Interventions


Book Description

This is an open access title available under the terms of a CC BY-NC 4.0 International licence. It is free to read at Oxford Scholarship Online and offered as a free PDF download from OUP and selected open access locations. Before new interventions are released into disease control programmes, it is essential that they are carefully evaluated in field trials'. These may be complex and expensive undertakings, requiring the follow-up of hundreds, or thousands, of individuals, often for long periods. Descriptions of the detailed procedures and methods used in the trials that have been conducted have rarely been published. A consequence of this, individuals planning such trials have few guidelines available and little access to knowledge accumulated previously, other than their own. In this manual, practical issues in trial design and conduct are discussed fully and in sufficient detail, that Field Trials of Health Interventions may be used as a toolbox' by field investigators. It has been compiled by an international group of over 30 authors with direct experience in the design, conduct, and analysis of field trials in low and middle income countries and is based on their accumulated knowledge and experience. Available as an open access book via Oxford Medicine Online, this new edition is a comprehensive revision, incorporating the new developments that have taken place in recent years with respect to trials, including seven new chapters on subjects ranging from trial governance, and preliminary studies to pilot testing.




Stochastic Processes in Epidemic Theory


Book Description

This collection of papers gives a representative cross-selectional view of recent developments in the field. After a survey paper by C. Lefèvre, 17 other research papers look at stochastic modeling of epidemics, both from a theoretical and a statistical point of view. Some look more specifically at a particular disease such as AIDS, malaria, schistosomiasis and diabetes.




Mathematical Biology


Book Description

This text presents mathematical biology as a field with a unity of its own, rather than only the intrusion of one science into another. The book focuses on problems of contemporary interest, such as cancer, genetics, and the rapidly growing field of genomics.