Molecular Biology of the Cell
Author :
Publisher :
Page : 0 pages
File Size : 45,78 MB
Release : 2002
Category : Cells
ISBN : 9780815332183
Bacillus Subtilis
Author : David Dubnau
Publisher : Elsevier
Page : 391 pages
File Size : 30,10 MB
Release : 2012-12-02
Category : Nature
ISBN : 032315252X
Book Description
The Molecular Biology of the Bacilli, Volume I: Bacillus subtilis focuses on areas of research traditionally investigated in Bacillus subtilis, as well as topics in which outstanding progress has been made. It discusses the sporulation, defective bacteriophage, and transformation of Bacillus subtilis. Organized into 11 chapters, the book begins with the genetic map of Bacillus subtilis, followed by DNA replication and RNA polymerase of the said species. The book then describes the translational apparatus of Bacillus subtilis. It also explains the genetic transformation in Bacillus subtilis; the sporulation genes; the regulatory mechanisms in the development of lytic bacteriophages in this species; the temperate Bacillus subtilis phages; the specialized transduction in Bacillus subtilis; and molecular cloning in this organism. Lastly, the book considers the most economically important areas of the microbiological industry employing bacilli, including the production of enzymes, nucleosides, riboflavin, and preparations pathogenic to insects. This book will be useful to scientists who are concerned with the use of Bacillus subtilis as a tool for the study of molecular biology and to those who wish to increase the medical, veterinary, and industrial usefulness of this and related organisms.
Snyder and Champness Molecular Genetics of Bacteria
Author : Tina M. Henkin
Publisher : John Wiley & Sons
Page : 642 pages
File Size : 31,79 MB
Release : 2020-10-27
Category : Science
ISBN : 1555819753
Book Description
The single most comprehensive and authoritative textbook on bacterial molecular genetics Snyder & Champness Molecular Genetics of Bacteria is a new edition of a classic text, updated to address the massive advances in the field of bacterial molecular genetics and retitled as homage to the founding authors. In an era experiencing an avalanche of new genetic sequence information, this updated edition presents important experiments and advanced material relevant to current applications of molecular genetics, including conclusions from and applications of genomics; the relationships among recombination, replication, and repair and the importance of organizing sequences in DNA; the mechanisms of regulation of gene expression; the newest advances in bacterial cell biology; and the coordination of cellular processes during the bacterial cell cycle. The topics are integrated throughout with biochemical, genomic, and structural information, allowing readers to gain a deeper understanding of modern bacterial molecular genetics and its relationship to other fields of modern biology. Although the text is centered on the most-studied bacteria, Escherichia coli and Bacillus subtilis, many examples are drawn from other bacteria of experimental, medical, ecological, and biotechnological importance. The book's many useful features include Text boxes to help students make connections to relevant topics related to other organisms, including humans A summary of main points at the end of each chapter Questions for discussion and independent thought A list of suggested readings for background and further investigation in each chapter Fully illustrated with detailed diagrams and photos in full color A glossary of terms highlighted in the text While intended as an undergraduate or beginning graduate textbook, Molecular Genetics of Bacteria is an invaluable reference for anyone working in the fields of microbiology, genetics, biochemistry, bioengineering, medicine, molecular biology, and biotechnology. "This is a marvelous textbook that is completely up-to-date and comprehensive, but not overwhelming. The clear prose and excellent figures make it ideal for use in teaching bacterial molecular genetics." —Caroline Harwood, University of Washington
Molecular Biological Methods for Bacillus
Author : Colin R. Harwood
Publisher : Wiley
Page : 618 pages
File Size : 33,40 MB
Release : 1991-02-18
Category : Science
ISBN : 9780471923930
Book Description
Molecular Biological Methods for Bacillus Edited by C. R. Harwood, Department of Microbiology, University of Newcastle upon Tyne, UK and S. M. Cutting, The Biological Laboratories, Harvard University, USA This volume represents the first major attempt to produce a compendium of the experimental methods used for the analysis of Bacillus, one of the most important procaryotic genera. Since the pioneering work on the transformation and genetic analysis of Bacillus subtilis by John Spizizen and his colleagues in the late 1950s this microorganism has been extensively studied and is now one of the best understood. More than forty of the world’s leading researchers in the field have generously contributed experimental procedures—devised and used in their laboratories—to this book. The aim throughout has been to present methods as simple step-by-step protocols which have been thoroughly tried and tested. The context in which the methods are used is discussed in detail and relevant information provided on the physiology and genetics of Bacillus. In addition valuable support is provided in the form of troubleshooting tips and advice on safety, the preparation of reagents, and the use of equipment. The book will be invaluable to those working with the genus Bacillus and related genera—both established researchers and those wishing to use this important microorganism for the first time.
The Molecular Biology of the Bacilli
Author : David Dubnau
Publisher : Elsevier
Page : 276 pages
File Size : 23,13 MB
Release : 2012-12-02
Category : Nature
ISBN : 0323158196
Book Description
The Molecular Biology of the Bacilli: Volume II is a collection of material relevant to the basic knowledge of the bacillus system and to the development of the bacillus system for industrial applications. This volume presents bacillus research studies on the unique characteristics of bacilli and its interesting comparisons with other bacteria, specifically Escherichia coli. The first four chapters focus on the Bacillus subtilis, specifically the translational specificity, DNA repair, chemotaxis, and sporulation. Chapter 5 discusses the protoplast fusion in bacillus while Chapter 6 delves on the secretion of proteins by bacilli. Chapter 7 explores the function of bacilli as insecticide. Bacillus thuringiensis is also mentioned in this chapter. This topic is further discussed in Chapter 8 where the genetics and molecular biology of B. thuringiensis are discussed. This volume aims to be of help to students and researchers in various fields of biochemistry, genetics, biological sciences, and microbiology.
Molecular Basis of Bacterial Pathogenesis
Author : Barbara H. Iglewski
Publisher : Elsevier
Page : 486 pages
File Size : 39,85 MB
Release : 1990-01-01
Category : Science
ISBN : 0323148670
Book Description
Molecular Basis of Bacterial Pathogenesis focuses on the molecular mechanism of disease associated with bacterial pathogens. Topics covered include the population genetics of bacterial pathogenesis; environmental modulation of gene expression in gram-negative pathogens; and bacterial invasion and intracellular growth. Bacterial toxins are also discussed. This volume is comprised of 20 chapters and begins with an overview of pathogenesis, paying particular attention to common elements and genetic mechanisms of regulation. The discovery that many bacterial pathogens are clonal, with individual clones often having a greater virulence than others, is then considered. The next section deals with the regulation of synthesis of surface components and their role in colonization of the host and/or evasion of the host immune defense systems; antigenic variation and its role in evasion of the host immune response; and the role of iron acquisition systems in the colonization of the host. Subsequent chapters explore the invasion and intracellular growth of facultative and obligate intracellular parasites. The last section is devoted to studies on the role of bacterial toxic products in pathogenesis. Bacterial lipopolysaccharides (endotoxins) and exotoxins are described. This book should be of interest to molecular biologists, physiologists, clinical specialists, pathologists, and geneticists.
Bacillus
Author : Peter Graumann
Publisher : Caister Academic Press Limited
Page : 0 pages
File Size : 35,16 MB
Release : 2012
Category : Science
ISBN : 9781904455974
Book Description
Bacillus subtilis has become widely adopted as a model organism for laboratory studies and is one of the best understood prokaryotes in terms of molecular and cellular biology. Its superb genetic amenability and relatively large size have provided powerful tools to investigate a bacterium in all possible aspects. This reference work provides a comprehensive and up-to-date analysis of the current knowledge and new research in Bacillus molecular and cellular biology. Subjects covered include chromosome replication, DNA repair, chromosome segregation, cell division, transcription and translation, RNA-mediated regulation, general and regulatory proteolysis, the actin-like MreB cytoskeleton, the membrane proteome, the cell wall, endospore formation, biofilms, multicellularity and social behaviour, competence and transformation.
The Molecular Biology of Viruses
Author : John Colter
Publisher : Elsevier
Page : 747 pages
File Size : 28,5 MB
Release : 2012-12-02
Category : Science
ISBN : 0323142737
Book Description
The Molecular Biology of Viruses is a collection of manuscripts presented at the Third Annual International Symposium of the Molecular Biology of Viruses, held in the University of Alberta, Canada on June 27-30, 1966, sponsored by the Faculty of Medicine of the University of Alberta. This book is organized into eight parts encompassing 36 chapters that emphasize the biosynthetic steps involved in polymer duplication. The first two parts explore the specialized processes of the cycle of virulent and temperate bacteriophage multiplication. These parts also deal with the production, regulation of development, and selectivity of these bacteriophages. The subsequent two parts look into the heterozygosity, mutation, structure, function, and mode of infection of single-stranded DNA and RNA bacteriophages. The discussions then shift to the biological and physicochemical aspects, biosynthesis, translation, genetics, and replication of mammalian DNA and RNA viruses. The concluding parts describe the homology, interaction, functions, mechanism of transformation, metabolism, and carcinogenic activity of oncogenic viruses. This book is of great benefit to biochemists, biophysicists, geneticists, microbiologists, and virologists.
Tuberculosis and the Tubercle Bacillus
Author : William R. Jacobs, Jr.
Publisher : John Wiley & Sons
Page : 1379 pages
File Size : 32,32 MB
Release : 2017-09-01
Category : Medical
ISBN : 1683673050
Book Description
Can today's innovative practices and molecular tools tame this ancient disease? One third of the world's population is infected with tuberculosis (TB), with about 10 million new cases annually. To combat TB and its agent, Mycobacterium tuberculosis, the World Health Organization launched The End TB Strategy, which aims to slash the suffering and cost of TB by 2035. This makes the second edition of Tuberculosis and the Tubercle Bacillus, edited by Jacobs, McShane, Mizrahi, and Orme, an extremely valuable resource for scientists and clinicians. The editors have gathered their colleagues from around the world to present the latest on the molecular biology of M. tuberculosis and related species, the host-pathogen interactions that enable invasion, and the host's immune response to M. tuberculosis infection. The basic, clinical, and translational research presented in this book supports the goals of WHO's End TB Strategy by driving toward the development of effective vaccines, rapid molecular diagnostics, and anti-TB drugs. Creating an effective tuberculosis vaccine. Understand the innate and adaptive immune response to M. tuberculosis infection, its study in established animal models, and how this information is being used to develop new vaccines against TB. Formulating new antituberculosis drugs. Learn the challenges and methods for evaluating new drugs in preclinical trials with a focus on drugs that work against "persisters" and those that act on the electron transport complex and ATP synthase of M. tuberculosis. Overcoming the challenges of diagnosing tuberculosis. Review new diagnostic tools that are simple, rapid, affordable, specific, sensitive, and safe, including molecular-based diagnostic methods such as GeneXpert MTB/RIF. Using molecular, genomic, and bioinformatics tools to understand the biology and evolution of Mycobacterium. Explore current research on the molecular mechanisms that M. tuberculosis uses to evade the immune system, enter a state of nonreplicating persistence, and become reactivated. The second edition of Tuberculosis and the Tubercle Bacillus presents the latest research on a microorganism that is exquisitely well adapted to its human host. This pathogen continues to confound scientists, clinicians, and public health specialists, who will all find much valuable information in this comprehensive set of reviews.
Molecular Cloning and Gene Regulation in Bacilli
Author : A Ganesan
Publisher : Elsevier
Page : 381 pages
File Size : 13,77 MB
Release : 2012-12-02
Category : Science
ISBN : 0323153097
Book Description
Molecular Cloning and Gene Regulation in Bacilli presents the proceedings of the 1981 Cetus Conference on Genetics held at Stanford University, Stanford, California. It summarizes both basic and applied aspects of bacilli genetics. It discusses significant advances made in understanding chromosome structure, gene arrangement, molecular cloning, cloned gene expression, DNA metabolism, transcription, and translation. Divided into five sessions, the book starts by discussing the DNA sequence from RNA intergenic spaces of Bacillus subtilis rRNA gene sets, the construction of a bifunctional cosmid vector of large DNA segments, and the mating system of bacilli. Molecular cloning session covers complementation system and dominance analyses in Bacillus, genetic fusion of Escherichia coli lac genes to a Bacillus subtilis promoter, and DNA cloning of B. subtilis. It also describes the construction of trimethoprim resistant B. subtilis plasmid and expression of E. coli trp genes cloned in B. subtilis. Session III encompasses chapters that discuss protein secretion by bacilli; regulation of alpha-amylase production in B. subtilis; entomocidal toxin translation of B. thuringiensis; and expression of crystal protein, heterologous, and eukaryotic genes in bacilli. Session IV focuses on various aspects of DNA metabolism of bacilli, such as the interaction of bacterial chromosome with cell membrane; plasmid DNA in competent cells and protoplasts of B. subtilis; analysis of peptides synthesized by B. subtilis mutants; and DNA repair, uptake, restriction, modification, and recombination. The final session examines species-specific translation, control of gene expression and replications in plasmids, development of expression-vector in B. subtilis, and regulatory modifications of RNA polymerase. Each chapter is presented in an experimental manner, consisting of a summary of the study, materials and methods, results, as well as references.
