The NEURON Book


Book Description

The authoritative reference on NEURON, the simulation environment for modeling biological neurons and neural networks that enjoys wide use in the experimental and computational neuroscience communities. This book shows how to use NEURON to construct and apply empirically based models. Written primarily for neuroscience investigators, teachers, and students, it assumes no previous knowledge of computer programming or numerical methods. Readers with a background in the physical sciences or mathematics, who have some knowledge about brain cells and circuits and are interested in computational modeling, will also find it helpful. The NEURON Book covers material that ranges from the inner workings of this program, to practical considerations involved in specifying the anatomical and biophysical properties that are to be represented in models. It uses a problem-solving approach, with many working examples that readers can try for themselves.




The Neuron


Book Description

Intended for use by advanced undergraduate, graduate and medical students, this book presents a study of the unique biochemical and physiological properties of neurons, emphasising the molecular mechanisms that generate and regulate their activity.




Electrophysiology of the Neuron


Book Description

This manual and disk, available in IBM PC and Macintosh formats, accompanies Shepherd's Neurobiology, 3/e. It can be used separately even though it is keyed to the textbook. The 17 experiments investigate such areas as the resting membrane potential, action potential, voltage clamp, physiological properties of nerve cells, and synaptic potentials. The program allows students to propagate the action potential, adjust various parameters and observe the effects on nerve cell firing. Students will learn about equilibrium potentials and the effects of changing ion concentrations, as well as passive and active membrane properties. Separate experiments analyze sodium ion and potassium ion currents, the voltage dependence of these currents, and sleep vs. waking in single neurons. Study questions are provided throughout. This ingeniously-designed program will benefit all undergraduate students of neuroscience.




Foundations of the Neuron Doctrine


Book Description

The neuron doctrine, first formulated in 1891, states that the brain is constructed of individual neurons, organized into functioning circuits that mediate behavior. Above all else, this is the main concept that underlies all of modern neuroscience. This 25th Aniversary Edition of The Foundations of the Neuron Doctrine explains how this theory was the product of an explosion of histological studies and vigorous debates near the end of the nineteenth century by an extraordinary group of scientists, most importantly the leading figure of the time, Santiago Ramon y Cajal of Spain, and includes the foremost nervous system investigators of many countries, such as Albrecht Kolliker, Sigmund Freud, Wilhelm His, August Forel, Fritdjof Nansen and Gustav Retzius.




Neuronal Dynamics


Book Description

This solid introduction uses the principles of physics and the tools of mathematics to approach fundamental questions of neuroscience.




From Neurons to Neighborhoods


Book Description

How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.




Dawn of the Neuron


Book Description

In science, sometimes it is best to keep things simple. Initially discrediting the discovery of neurons in jellyfish, mid-nineteenth-century scientists grouped jellyfish, comb-jellies, hydra, and sea anemones together under one term - "coelenterates" - and deemed these animals too similar to plants to warrant a nervous system. In Dawn of the Neuron, Michel Anctil shows how Darwin's theory of evolution completely eradicated this idea and cleared the way for the modern study of the neuron. Once zoologists accepted the notion that varying levels of animal complexity could evolve, they began to use simple-structured creatures such as coelenterates and sponges to understand the building blocks of more complicated nervous systems. Dawn of the Neuron provides fascinating insights into the labours and lives of scientists who studied coelenterate nervous systems over several generations, and who approached the puzzling origin of the first nerve cells through the process outlined in evolutionary theory. Anctil also reveals how these scientists, who were willing to embrace improved and paradigm-changing scientific methods, still revealed their cultural backgrounds, their societal biases, and their attachments to schools of thought and academic traditions while presenting their ground-breaking work. Their attitudes toward the neuron doctrine - where neurons are individual, self-contained cells - proved decisive in the exploration of how neurons first emerged. Featuring photographs and historical sketches to illustrate this quest for knowledge, Dawn of the Neuron is a remarkably in-depth exploration of the link between Darwin's theory of evolution and pioneering studies and understandings of the first evolved nervous systems




Discovering the Brain


Book Description

The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."




Basic Neurochemistry


Book Description

Basic Neurochemistry, Eighth Edition, is the updated version of the outstanding and comprehensive classic text on neurochemistry. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from intracellular trafficking, stem cells, adult neurogenesis, regeneration, and lipid messengers. It contains expanded coverage of all major neurodegenerative and psychiatric disorders, including the neurochemistry of addiction, pain, and hearing and balance; the neurobiology of learning and memory; sleep; myelin structure, development, and disease; autism; and neuroimmunology. Completely updated text with new authors and material, and many entirely new chapters Over 400 fully revised figures in splendid color 61 chapters covering the range of cellular, molecular and medical neuroscience Translational science boxes emphasizing the connections between basic and clinical neuroscience Companion website at http://elsevierdirect.com/companions/9780123749475




Molecular Biology of the Neuron


Book Description

Nerve cells - neurons - are arguably the most complex of all cells. From the action of these cells comes movement, thought and consciousness. It is a challenging task to understand what molecules direct the various diverse aspects of their function. This has produced an ever-increasing amount of molecular information about neurons, and only in Molecular Biology of the Neuron can a large part of this information be found in one source. In this book, a non-specialist can learn about the molecules that control information flow in the brain or the progress of brain disease in an approachable format, while the expert has access to a wealth of detailed information from a wide range of topics impacting on his or her field of endeavour. The text is designed to achieve a balance of accessibility and broad coverage with up-to-date molecular detail. In the six years since the first edition of Molecular Biology of the Neuron there has been an explosion in the molecular information about neurons that has been discovered, and this information is incorporated into this second edition. Entirely new chapters have been introduced where recent advances have made a new aspect of neuronal function more comprehensible at the molecular level. Written by leading researchers in the field, the book provides an essential overview of the molecular structure and function of neurons, and will be an invaluable tool to students and researchers alike.