The Onchocerciasis Control Programme in West Africa


Book Description

An analysis of the many factors that have contributed to the striking success of the Onchocerciasis Control Program in West Africa (OCP), a major public health initiative now entering its twenty-first year. Throughout its history, OCP has been distinguished by its large size, the complexity of its operations, the long time frame needed for success, and the degree of commitment required by donors and participating countries alike. The Program has also been distinguished by its explicit aim to eliminate a disease, which has been a major obstacle to socioeconomic development as well as a cause of great disability and suffering. In examining the Program's many successful features, the author, who has directed OCP since late 1980, draws upon extensive personal experience, supported by the results of several external evaluations, to show how international collaboration, careful planning, and well managed field operations can overcome what may seem to be insurmountable obstacles. Throughout this analysis, an effort is made to extract lessons useful in the management of other large public health programs. The book also gives careful attention to managerial principles that will be important when OCP ceases operation and participating countries take over responsibility for the surveillance and management of recrudescence. The book has two parts. Chapters in the first part give a detailed account of the history, structure, operation, and achievements of OCP. Part two, on the management of OCP, explains how sound budgeting, detailed plans, time-limited goals, task-focused training, and careful computation of costs worked to maintain well-organized operations and keep staff motivated and efficient




Riverblindness in Africa


Book Description

The remarkable story of how a large public-private partnership worked to control and defeat riverblindness—a scourge which had devastated rural communities and impeded socioeconomic development throughout much of Sub-Saharan Africa for generations. Riverblindness (onchocerciasis)—a pervasive neglected disease, transmitted by the blackfly, that causes horrific itching, disfigurement, and loss of vision—is also known as "lion's stare" in reference to the fixed, lifeless glare of the eyes blinded by the disease. The disease has destroyed countless lives for generations, particularly in Africa. Its effects are so devastating that the areas where it is most common (large expanses of land around rivers where the fly breeds) end up abandoned as villages move farther and farther away to more arid environments in order to escape the fly-biting, and hence the disease. The disease devastates communities from multiple angles: a large portion of each stricken community's population is disabled, often permanently blind in the prime of life, placing a burden on the rest, and communities' efforts to escape infection force them to move to areas where farming is less productive. To defeat riverblindness would not only release these communities from the heavy toll of the disease, but would also open more fertile areas in Africa to be inhabited, thus alleviating extreme poverty. These were the goals of the World Bank, led by then-president Robert McNamara, when launching a partnership to combat riverblindness more than forty-five years ago. In this book, Bruce Benton tells the remarkable story of that partnership's success. An authoritative account of the launch and scale-up of the effort, the book covers the transformation of the fight from a top-down high-tech operation to a grassroots drug treatment program covering all of endemic Africa. How, Benton asks, did the effort become such a unique partnership of UN agencies, donors, NGOs, a major pharmaceutical company, universities, African governments, and the stricken communities themselves? Highlighting the importance of disease control in alleviating absolute poverty and promoting development, Benton examines the key developments, individuals, and notable qualities of the partnership in realizing success. He also extracts lessons from this particular story for addressing future challenges through partnership. Drawing on Benton's twenty years of experience managing the riverblindness program for the World Bank, along with extensive research and interviews with 100+ players in the program, Riverblindness in Africa is the first and only book of its kind. The story of the battle has an epic scale, both in terms of geography and the vast number of people and organizations involved. It provides a template for a broad range of global health efforts and is an excellent example of evolving, increasingly effective approaches to disease control and elimination.







Under the Big Tree


Book Description

Powerful stories of the debilitating effects of neglected tropical diseases throughout the world, highlighting the successes and challenges of those fighting to eliminate them. Neglected tropical diseases (NTDs) affect over one billion of the world's poorest people. More than 170,000 people die from NTDs each year, and many more suffer from blindness, disability, disfigurement, cognitive impairment, and stunted growth. Yet NTDs are treatable and preventable, and the annual cost of treatment is incredibly low. In Under the Big Tree, public health leader Ellen Agler and award-winning writer Mojie Crigler tell the moving stories of those struggling with these diseases and the life-saving work that can be—and has been—done to combat NTDs. They introduce readers to people from all walks of life—from car washers in Lake Victoria and surgeons on motorbikes to under-resourced local nongovernmental organizations (NGOs) and Big Pharma scientists—as they chronicle what has been called the largest public health program in the world. On the one hand, the solutions are simple: deliver medication to people who need it and leverage local systems to offer prevention, treatment, and education. On the other hand, solutions are complex: navigating local and national politics, delivering treatment to some of the most remote, vulnerable communities, and coordinating global and local donors, international NGOs, thousands of health workers, and millions of citizens. Drawing on interviews with major players in the NTD world who share their cutting-edge research and frontline experiences, Under the Big Tree is a moving introduction to the science, the tactics, and the partnerships working to address these terrible diseases that affect the most vulnerable people in the world. With a foreword by Bill Gates, this book fascinates, inspires, and gives readers concrete steps for further engagement.




Entomopathogenic Bacteria: from Laboratory to Field Application


Book Description

Entomopathogenic bacteria (Bacillus thuringiensis and B. sphaericus) are increasingly used as biopesticides to control larval insect populations which are either agricultural or forestry pests and to reduce those which as adults are vectors of severe human diseases. This new book, the first since 1993 to address all aspects of entomopathogenic bacteria, provides undergraduate and graduate students as well as research scientists with a complete, modern view of this important group of bacteria. The authors, chosen for their sustained contributions to the field, cover both fundamental and applied research in this area. The main topics include bacterial ecology and taxonomy, toxin diversity, activity and mode of action, regulation and environment of the genes, safety and ecotoxicology, production and field application of the bacteria, and outbreaks of resistant populations. The book concludes with the most recent data obtained on transgenic biotechnology and addresses environmental impact issues.




Water and Sanitation-Related Diseases and the Changing Environment


Book Description

The revised and updated second edition of Water and Sanitation Related Diseases and the Changing Environment offers an interdisciplinary guide to the conditions responsible for water and sanitation related diseases. The authors discuss the pathogens, vectors, and their biology, morbidity and mortality that result from a lack of safe water and sanitation. The text also explores the distribution of these diseases and the conditions that must be met to reduce or eradicate them. The text includes contributions from authorities from the fields of climate change, epidemiology, environmental health, environmental engineering, global health, medicine, medical anthropology, nutrition, population, and public health. Covers the causes of individual diseases with basic information about the diseases and data on the distribution, prevalence, and incidence as well as interconnected factors such as environmental factors. The authors cover access to and maintenance of clean water, and guidelines for the safe use of wastewater, excreta, and grey water, plus examples of solutions. Written for students, and professionals in infectious disease, public health and medicine, chemical and environmental engineering, and international affairs, the second edition of Water and Sanitation Related Diseases and the Changing Environment isa comprehensive resource to the conditions responsible for water and sanitation related diseases.




Investing to Overcome the Global Impact of Neglected Tropical Diseases


Book Description

"The presence, or absence, of neglected tropical diseases (NTDs) can be seen as a proxy for poverty and for the success of interventions aimed at reducing poverty. Today, coverage of the public-health interventions recommended by the World Health Organization (WHO) against NTDs may be interpreted as a proxy for universal health coverage and shared prosperity - in short, a proxy for coverage against neglect. As the world's focus shifts from development to sustainable development, from poverty eradication to shared prosperity, and from disease-specific goals to universal health coverage, control of NTDs will assume an important role towards the target of achieving universal health coverage, including individual financial risk protection. Success in overcoming NTDs is a "litmus test" for universal health coverage against NTDs in endemic countries. The first WHO report on NTDs (2010) set the scene by presenting the evidence for how these interventions had produced results. The second report (2013) assessed the progress made in deploying them and detailed the obstacles to their implementation. This third report analyses for the first time the investments needed to achieve the scale up of implementation required to achieve the targets of the WHO Roadmap on NTDs and universal coverage against NTDs. INVESTING TO OVERCOME THE GLOBAL IMPACT OF NEGLECTED TROPICAL DISEASES presents an investment strategy for NTDs and analyses the specific investment case for prevention, control, elimination and eradication of 12 of the 17 NTDs. Such an analysis is justified following the adoption by the Sixty-sixth World Health Assembly in 2013 of resolution WHA6612 on neglected tropical diseases, which called for sufficient and predictable funding to achieve the Roadmap's targets and sustain control efforts. The report cautions, however, that it is wise investment and not investment alone that will yield success. The report registers progress and challenges and signals those that lie ahead. Climate change is expected to increase the spread of several vector-borne NTDs, notably dengue, transmission of which is directly influenced by temperature, rainfall, relative humidity and climate variability primarily through their effects on the vector. Investments in vector-borne diseases will avoid the potentially catastrophic expenditures associated with their control. The presence of NTDs will thereby signal an early warning system for climate-sensitive diseases. The ultimate goal is to deliver enhanced and equitable interventions to the most marginalized populations in the context of a changing public-health and investment landscape to ensure that all peoples affected by NTDs have an opportunity to lead healthier and wealthier lives."--Publisher's description.




Neglected Tropical Diseases - Sub-Saharan Africa


Book Description

This book provides an overview on the major neglected tropical diseases (NTDs) occurring in Sub-Saharan Africa, such as Leishmaniasis, Buruli Ulcer and Schistosomiasis. In well-structured chapters epidemiology and biology of these parasitic diseases will be discussed in detail. Further, diagnostics and therapeutic approaches as well as prevention strategies will be reviewed. The book will be of interest to basic researchers and clinicians engaged in infectious disease, tropical medicine, and parasitology, and a must-have for scientists specialized in the characteristics of the Sub-Saharan region.




Toolkit for Integrated Vector Management in Sub-Saharan Africa (A)


Book Description

This toolkit for integrated vector management (IVM) is designed to help national and regional programme managers coordinate across sectors to design and run large IVM programmes. It is an extension of earlier guidance and teaching material published by the World Health Organization (WHO): Handbook for integrated vector management Monitoring and evaluation indicators for integrated vector management Guidance on policy-making for integrated vector management and Core structure for training curricula on integrated vector management. The toolkit provides the technical detail required to plan implement monitor and evaluate an IVM approach. IVM can be used when the aim is to control or eliminate vector-borne diseases and can also contribute to insecticide resistance management. This toolkit provides information on where vector-borne diseases are endemic and what interventions should be used presenting case studies on IVM as well as relevant guidance documents for reference. The diseases that are the focus of this toolkit are malaria lymphatic filariasis dengue leishmaniasis onchocerciasis human African trypanosomiasis and schistosomiasis. It also includes information on other viral diseases (Rift Valley fever West Nile fever Chikungunya yellow fever) and trachoma. If other vector-borne diseases appear in a country or area vector control with an IVM approach should be adopted as per national priorities. Malaria as one of the most important vector-borne diseases in sub-Saharan Africa is the main focus of this document. Programmes targeting other vector-borne diseases can learn from the experiences gained from malaria vector control and presented here.




Emergency Vector Control Using Chemicals (2nd Edition)


Book Description

electing the appropriate control chemical and the means of application, together with advice on planning an implementation programme.