Author : Kwang-Sup Soh
Publisher : Springer Science & Business Media
Page : 327 pages
File Size : 31,3 MB
Release : 2011-11-03
Category : Medical
ISBN : 1461406013
Proceedings from the first International Symposium on Primo Vascular System 2010 (ISPS 2010) with special topics on cancer and regeneration was held in Jecheon, Korea during September 17-18, 2010. Includes coverage of new study results that have better revealed the functional aspects of PVS, including its roles in the areas of regenerative medicine and cancer.
Author : Arthur O'Malley
Publisher : Routledge
Page : 384 pages
File Size : 42,47 MB
Release : 2018-12-14
Category : Psychology
ISBN : 0429793936
Sensorimotor-Focused EMDR combines two hugely influential and effective therapies, EMDR therapy and sensorimotor psychotherapy, to provide a new approach. In doing so, the book supports the widely held view of psychotherapists that in trauma the primary store of neurological information is somatic rather than cognitive. Many therapists trained in EMDR find that additional resources are needed for patients who present with symptoms of complex trauma and dissociation. This is because EMDR is primarily a top-down approach based on CBT, with the addition of bilateral stimulation (BLS) in visual, tactile and auditory modalities. By contrast, Sensorimotor-Focused EMDR takes a body-based and bottom-up approach that seeks to resolve trauma by reprocessing information at multiple levels – in the gut-brain, the heart-brain and the head-brain, as well as in the endocrine, immune and nervous systems. Fully revised since The Art of BART (2015), the book looks at the latest advances in neuroscience, including research into the effectiveness of psychotherapy and the mysteries of consciousness and the development of mind. It also looks at the role of newly discovered organs, the mesentery and the interstitium, and provides clear anatomical evidence for the communication of biophotons in energy channels known as the primo vascular system. SF-EMDR is the only therapy that fully integrates Western theories of affective neuroscience with Eastern observations on activation of chakras, pranas and energies, and in doing so it offers strong potential for enhanced outcomes and optimized performance for patients.
Author : Bong-Han Kim
Publisher : Curiouspages Publishing
Page : 114 pages
File Size : 32,56 MB
Release : 2016-12-14
Category : Medical
ISBN : 9780995770331
This book describes the first scientific evidence of the structures that correspond to the acupuncture meridians, and describes the anatomical purpose of the meridian system.
Author : Ronald J. Korthuis
Publisher : Morgan & Claypool Publishers
Page : 147 pages
File Size : 42,28 MB
Release : 2011
Category : Medical
ISBN : 1615041834
The aim of this treatise is to summarize the current understanding of the mechanisms for blood flow control to skeletal muscle under resting conditions, how perfusion is elevated (exercise hyperemia) to meet the increased demand for oxygen and other substrates during exercise, mechanisms underlying the beneficial effects of regular physical activity on cardiovascular health, the regulation of transcapillary fluid filtration and protein flux across the microvascular exchange vessels, and the role of changes in the skeletal muscle circulation in pathologic states. Skeletal muscle is unique among organs in that its blood flow can change over a remarkably large range. Compared to blood flow at rest, muscle blood flow can increase by more than 20-fold on average during intense exercise, while perfusion of certain individual white muscles or portions of those muscles can increase by as much as 80-fold. This is compared to maximal increases of 4- to 6-fold in the coronary circulation during exercise. These increases in muscle perfusion are required to meet the enormous demands for oxygen and nutrients by the active muscles. Because of its large mass and the fact that skeletal muscles receive 25% of the cardiac output at rest, sympathetically mediated vasoconstriction in vessels supplying this tissue allows central hemodynamic variables (e.g., blood pressure) to be spared during stresses such as hypovolemic shock. Sympathetic vasoconstriction in skeletal muscle in such pathologic conditions also effectively shunts blood flow away from muscles to tissues that are more sensitive to reductions in their blood supply that might otherwise occur. Again, because of its large mass and percentage of cardiac output directed to skeletal muscle, alterations in blood vessel structure and function with chronic disease (e.g., hypertension) contribute significantly to the pathology of such disorders. Alterations in skeletal muscle vascular resistance and/or in the exchange properties of this vascular bed also modify transcapillary fluid filtration and solute movement across the microvascular barrier to influence muscle function and contribute to disease pathology. Finally, it is clear that exercise training induces an adaptive transformation to a protected phenotype in the vasculature supplying skeletal muscle and other tissues to promote overall cardiovascular health. Table of Contents: Introduction / Anatomy of Skeletal Muscle and Its Vascular Supply / Regulation of Vascular Tone in Skeletal Muscle / Exercise Hyperemia and Regulation of Tissue Oxygenation During Muscular Activity / Microvascular Fluid and Solute Exchange in Skeletal Muscle / Skeletal Muscle Circulation in Aging and Disease States: Protective Effects of Exercise / References
Author : Jeffrey W. Kiel
Publisher : Biota Publishing
Page : 83 pages
File Size : 31,99 MB
Release : 2011-02-01
Category : Medical
ISBN : 1615041699
This presentation describes the unique anatomy and physiology of the vascular beds that serve the eye. The needs for an unobstructed light path from the cornea to the retina and a relatively fixed corneal curvature and distance between refractive structures pose significant challenges for the vasculature to provide nutrients and remove metabolic waste. To meet these needs, the ocular vascular beds are confined to the periphery of the posterior two thirds of the eye and a surrogate circulation provides a continuous flow of aqueous humor to nourish the avascular cornea, lens and vitreous compartment. The production of aqueous humor (and its ease of egress from the eye) also generates the intraocular pressure (IOP), which maintains the shape of the eye. However, the IOP also exerts a compressing force on the ocular blood vessels that is higher than elsewhere in the body. This is particularly true for the intraocular veins, which must have a pressure higher than IOP to remain patent, and so the IOP is the effective venous pressure for the intraocular vascular beds. Consequently, the ocular circulation operates at a lower perfusion pressure gradient than elsewhere in the body and is more at risk for ischemic damage when faced with low arterial pressure, particularly if IOP is elevated. This risk and the specialized tissues of the eye give rise to the fascinating physiology of the ocular circulations.
Author : Dániel Margócsy
Publisher : BRILL
Page : 537 pages
File Size : 49,27 MB
Release : 2018-05-23
Category : Medical
ISBN : 9004336303
Winner of the Third Neu-Whitrow Prize (2021) granted by the Commission on Bibliography and Documentation of IUHPS-DHST Additional background information This book provides bibliographic information, ownership records, a detailed worldwide census and a description of the handwritten annotations for all the surviving copies of the 1543 and 1555 editions of Vesalius’ De humani corporis fabrica. It also offers a groundbreaking historical analysis of how the Fabrica traveled across the globe, and how readers studied, annotated and critiqued its contents from 1543 to 2017. The Fabrica of Andreas Vesalius sheds a fresh light on the book’s vibrant reception history and documents how physicians, artists, theologians and collectors filled its pages with copious annotations. It also offers a novel interpretation of how an early anatomical textbook became one of the most coveted rare books for collectors in the 21st century.
Author : Dominique Bagnard
Publisher : Springer Science & Business Media
Page : 163 pages
File Size : 49,30 MB
Release : 2011-04-27
Category : Medical
ISBN : 1461501199
Cell adhesion is one of the most important properties controlling embryonic development. Extremely precise cell-cell contacts are established according to the nature of adhesion molecules that are expressed on the cell surface. The identifica tion of several families of adhesion molecules, well conserved throughout evolu tion, has been the basis of a considerable amount of work over the past 20 years that contributed to establish functions of cell adhesion in almost all organs. Nowadays, cell adhesion molecules are not just considered as cellular glue but are thought to play critical roles in cell signaling. Their ability to influence cell proliferation, mi gration, or differentiation depends on both cell surface adhesion properties and acti vation of intracellular pathways. The next challenge will be to understand how these molecules interact with each other to ensure specific functions in the morphogen esis of very sophisticated systems. Indeed, by exploring the cellular and molecular mechanisms of nervous system development, the group of H. Fujisawa in Japan identified in 1987 an adhesion molecule, neuropilin, highly expressed in the neuro pile of amphibian optic tectum. Ten years later, two groups discovered that neuropilin is a receptor for guidance signals of the semaphorin family. Axon guidance is a critical step during brain development and the mechanisms ensuring growth cone navigation are beginning to be well understood. The semaphorins are bifunctional signals defining permissive or inhibitory pathways sensed by the growth cone.
Author : D. Neil Granger
Publisher : Morgan & Claypool Publishers
Page : 99 pages
File Size : 36,22 MB
Release : 2010
Category : Medical
ISBN : 1615041656
The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References
Author : Carolyn A. Staton
Publisher : John Wiley & Sons
Page : 410 pages
File Size : 43,12 MB
Release : 2007-01-11
Category : Medical
ISBN : 047002934X
Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and the full range of effects of a given test protein. Although the endothelial cell - its migration, proliferation, differentiation and structural rearrangement - is central to the angiogenic process, it is not the only cell type involved. the supporting cells, the extracellular matrix and the circulating blood with its cellular and humoral components also contribute. In this book, experts in the use of a diverse range of assays outline key components of these and give a critical appraisal of their strengths and weaknesses. Examples include assays for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures, assessment of endothelial and mural cell interactions, and such in vivo assays as the chick chorioallantoic membrane, zebrafish, corneal, chamber and tumour angiogenesis models. These are followed by a critical analysis of the biological end-points currently being used in clinical trials to assess the clinical efficacy of anti-angiogenic drugs, which leads into a discussion of the direction future studies should take. This valuable book is of interest to research scientists currently working on angiogenesis in both the academic community and in the biotechnology and pharmaceutical industries. Relevant disciplines include cell and molecular biology, oncology, cardiovascular research, biotechnology, pharmacology, pathology and physiology.
Author : Paul D. Thompson
Publisher : Springer Nature
Page : 191 pages
File Size : 48,51 MB
Release : 2020-01-25
Category : Medical
ISBN : 3030333043
This book provides an overview of statin-associated muscle symptoms (SAMS) from clinical presentation to treatment and possible metabolic causes. It examines the risk factors, presentations, diagnosis and differential diagnosis, clinical management, and financial costs of SAMS. The book also highlights patients’ perspectives on SAMS such as the psychosocial, emotional, and societal factors influencing their perceptions and experiences. Finally, the book presents the results of observational and clinical trials on the prevalence of SAMS, clinical trials for treatments, and potential future research approaches for improving the understanding and treatment of SAMS. A key addition to the Contemporary Cardiology series, Statin-Associated Muscle Symptoms is an essential resource for physicians, medical students, residents, fellows, and allied health professionals in cardiology, endocrinology, pharmacotherapy, primary care, and health promotion and disease prevention.
