Enzymes in blood plasma


Book Description







Isoenzymes


Book Description

Isoenzymes were 'discovered' 20 years ago and were at first regarded as interesting but rare occurrences. Since then a wealth of information on enzyme heterogeneity has accrued and it now seems likely that at least half of all enzymes exist as isoenzymes. This is important in many areas of biological and medical science. Thus isoenzyme studies have provided the main experimental substance for the neutral drift controversy in genetics and evolution; they have greatly extended our understanding of metabolic regulation not only in animals but also in bacteria and plants; their existence has made available a multitude of highly sensitive markers for the study of differentiation and development, as well as providing indices of aberrant gene expression in carcinogenesis and other pathological processes. Iso enzymes are also being used increasingly in diagnostic clinical bio chemistry. It is surprising that this phenomenon which affects such a high pro portion of enzymes and is clearly important in biochemistry should receive such scant attention in the standard textbooks of that subject, the formal treatment of isoenzymology in these rarely exceeding one or two pages. This may be because the 'pure biochemist' has tended to regard variation in enzyme properties between tissues more as an unwanted complication than as a potential source of insight into diversity of biological function.




Diagnostic Molecular Biology


Book Description

Diagnostic Molecular Biology, Second Edition describes the fundamentals of molecular biology in a clear, concise manner with each technique explained within its conceptual framework and current applications of clinical laboratory techniques comprehensively covered. This targeted approach covers the principles of molecular biology, including basic knowledge of nucleic acids, proteins and chromosomes; the basic techniques and instrumentations commonly used in the field of molecular biology, including detailed procedures and explanations; and the applications of the principles and techniques currently employed in the clinical laboratory. Topics such as whole exome sequencing, whole genome sequencing, RNA-seq, and ChIP-seq round out the discussion. Fully updated, this new edition adds recent advances in the detection of respiratory virus infections in humans, like influenza, RSV, hAdV, hRV but also corona. This book expands the discussion on NGS application and its role in future precision medicine. - Provides explanations on how techniques are used to diagnosis at the molecular level - Explains how to use information technology to communicate and assess results in the lab - Enhances our understanding of fundamental molecular biology and places techniques in context - Places protocols into context with practical applications - Includes extra chapters on respiratory viruses (Corona)




Principles and Applications of Molecular Diagnostics


Book Description

Principles and Applications of Molecular Diagnostics serves as a comprehensive guide for clinical laboratory professionals applying molecular technology to clinical diagnosis. The first half of the book covers principles and analytical concepts in molecular diagnostics such as genomes and variants, nucleic acids isolation and amplification methods, and measurement techniques, circulating tumor cells, and plasma DNA; the second half presents clinical applications of molecular diagnostics in genetic disease, infectious disease, hematopoietic malignancies, solid tumors, prenatal diagnosis, pharmacogenetics, and identity testing. A thorough yet succinct guide to using molecular testing technology, Principles and Applications of Molecular Diagnostics is an essential resource for laboratory professionals, biologists, chemists, pharmaceutical and biotech researchers, and manufacturers of molecular diagnostics kits and instruments. - Explains the principles and tools of molecular biology - Describes standard and state-of-the-art molecular techniques for obtaining qualitative and quantitative results - Provides a detailed description of current molecular applications used to solve diagnostics tasks




Human Biochemistry


Book Description

**Selected for Doody's Core TitlesĀ® 2024 in Biochemistry** Human Biochemistry, Second Edition provides a comprehensive, pragmatic introduction to biochemistry as it relates to human development and disease. Here, Gerald Litwack, award-wining researcher and longtime teacher, discusses the biochemical aspects of organ systems and tissue, cells, proteins, enzymes, insulins and sugars, lipids, nucleic acids, amino acids, polypeptides, steroids, and vitamins and nutrition, among other topics. Fully updated to address recent advances, the new edition features fresh discussions on hypothalamic releasing hormones, DNA editing with CRISPR, new functions of cellular prions, plant-based diet and nutrition, and much more. Grounded in problem-driven learning, this new edition features clinical case studies, applications, chapter summaries, and review-based questions that translate basic biochemistry into clinical practice, thus empowering active clinicians, students and researchers. - Presents an update on a past edition winner of the 2018 Most Promising New Textbook (College) Award (Texty) from the Textbook and Academic Authors Association and the PROSE Award of the Association of American Publishers - Provides a fully updated resource on current research in human and medical biochemistry - Includes clinical case studies, applications, chapter summaries and review-based questions - Adopts a practice-based approach, reflecting the needs of both researchers and clinically oriented readers




Tietz Clinical Guide to Laboratory Tests - E-Book


Book Description

This new edition of Norbert Tietz's classic handbook presents information on common tests as well as rare and highly specialized tests and procedures - including a summary of the utility and merit of each test. Biological variables that may affect test results are discussed, and a focus is placed on reference ranges, diagnostic information, clinical interpretation of laboratory data, interferences, and specimen types. New and updated content has been added in all areas, with over 100 new tests added. - Tests are divided into 8 main sections and arranged alphabetically. - Each test includes necessary information such as test name (or disorder) and method, specimens and special requirements, reference ranges, chemical interferences and in vivo effects, kinetic values, diagnostic information, factors influencing drug disposition, and clinical comments and remarks. - The most current and relevant tests are included; outdated tests have been eliminated. - Test index (with extensive cross references) and disease index provide the reader with an easy way to find necessary information - Four new sections in key areas (Preanalytical, Flow Cytometry, Pharmacogenomics, and Allergy) make this edition current and useful. - New editor Alan Wu, who specializes in Clinical Chemistry and Toxicology, brings a wealth of experience and expertise to this edition. - The Molecular Diagnostics section has been greatly expanded due to the increased prevalence of new molecular techniques being used in laboratories. - References are now found after each test, rather than at the end of each section, for easier access.




National Library of Medicine Current Catalog


Book Description

First multi-year cumulation covers six years: 1965-70.




Clinical Chemistry


Book Description

In its Seventh Edition, this acclaimed Clinical Chemistry continues to be the most student-friendly clinical chemistry text available. This edition not only covers the how of clinical testing but also places greater emphasis on the what, why, and when in order to help today's students fully understand the implications of the information covered, as well as the applicability of this crucial topic in practice. With clear explanations that strike just the right balance of analytic principles, techniques, and correlation of results with disease states, this edition has been fully updated with the latest information to help keep today's students at the forefront of today's science. New case studies, practice questions, and exercises provide ample opportunities to review and apply the topics covered through the text.