The S.M. Otieno Case


Book Description




The Future of African Customary Law


Book Description

This book promotes discussion and understanding of customary law and explores its continued relevance in sub-Saharan Africa. It considers the characteristics of customary law and efforts to ascertain and codify customary law, and how this body of law differs in content, form and status from legislation and common law.







Sepsis Management in Resource-limited Settings


Book Description

This book is open access under a CC BY 4.0 license. It constitutes a unique source of knowledge and guidance for all healthcare workers who care for patients with sepsis and septic shock in resource-limited settings. More than eighty percent of the worldwide deaths related to sepsis occur in resource-limited settings in low and middle-income countries. Current international sepsis guidelines cannot be implemented without adaptations towards these settings, mainly because of the difference in local resources and a different spectrum of infectious diseases causing sepsis. This prompted members of the Global Intensive Care working group of the European Society of Intensive Care Medicine (ESICM) and the Mahidol-Oxford Tropical Medicine Research Unit (MORU, Bangkok, Thailand) - among which the Editors – to develop with an international group of experts a comprehensive set of recommendations for the management of sepsis in resource-limited settings. Recommendations are based on both current scientific evidence and clinical experience of clinicians working in resource-limited settings. The book includes an overview chapter outlining the current challenges and future directions of sepsis management as well as general recommendations on the structure and organization of intensive care services in resource-limited settings. Specific recommendations on the recognition and management of patients with sepsis and septic shock in these settings are grouped into seven chapters. The book provides evidence-based practical guidance for doctors in low and middle income countries treating patients with sepsis, and highlights areas for further research and discussion.




Murder at the Mission


Book Description

Finalist for the 2022 Will Rogers Medallion Award “Terrific.” –Timothy Egan, The New York Times “A riveting investigation of both American myth-making and the real history that lies beneath.” –Claudio Saunt, author of Unworthy Republic From the New York Times bestselling author of Escape From Camp 14, a “terrifically readable” (Los Angeles Times) account of one of the most persistent “alternative facts” in American history: the story of a missionary, a tribe, a massacre, and a myth that shaped the American West In 1836, two missionaries and their wives were among the first Americans to cross the Rockies by covered wagon on what would become the Oregon Trail. Dr. Marcus Whitman and Reverend Henry Spalding were headed to present-day Washington state and Idaho, where they aimed to convert members of the Cayuse and Nez Perce tribes. Both would fail spectacularly as missionaries. But Spalding would succeed as a propagandist, inventing a story that recast his friend as a hero, and helped to fuel the massive westward migration that would eventually lead to the devastation of those they had purportedly set out to save. As Spalding told it, after uncovering a British and Catholic plot to steal the Oregon Territory from the United States, Whitman undertook a heroic solo ride across the country to alert the President. In fact, he had traveled to Washington to save his own job. Soon after his return, Whitman, his wife, and eleven others were massacred by a group of Cayuse. Though they had ample reason - Whitman supported the explosion of white migration that was encroaching on their territory, and seemed to blame for a deadly measles outbreak - the Cayuse were portrayed as murderous savages. Five were executed. This fascinating, impeccably researched narrative traces the ripple effect of these events across the century that followed. While the Cayuse eventually lost the vast majority of their territory, thanks to the efforts of Spalding and others who turned the story to their own purposes, Whitman was celebrated well into the middle of the 20th century for having "saved Oregon." Accounts of his heroic exploits appeared in congressional documents, The New York Times, and Life magazine, and became a central founding myth of the Pacific Northwest. Exposing the hucksterism and self-interest at the root of American myth-making, Murder at the Mission reminds us of the cost of American expansion, and of the problems that can arise when history is told only by the victors.




Between History and Histories


Book Description

This collection of case studies from around the world uses a new approach in historical anthropology, one that focuses on heterogeneity within cultures rather than coherence to explain how we commemorate certain events, while silencing others.




Saving Lives, Buying Time


Book Description

For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.




Handbook of Sepsis


Book Description

This practically oriented book provides an up-to-date overview of all significant aspects of the pathogenesis of sepsis and its management, including within the intensive care unit. Readers will find information on the involvement of the coagulation and endocrine systems during sepsis and on the use of biomarkers to diagnose sepsis and allow early intervention. International clinical practice guidelines for the management of sepsis are presented, and individual chapters focus on aspects such as fluid resuscitation, vasopressor therapy, response to multiorgan failure, antimicrobial therapy, and adjunctive immunotherapy. The closing section looks forward to the coming decade, discussing novel trial designs, sepsis in low- and middle-income countries, and emerging management approaches. The book is internatio nal in scope, with contributions from leading experts worldwide. It will be of value to residents and professionals/practitioners in the fields of infectious diseases and internal medicine, as well as to GPs and medical students.




A Companion to African Philosophy


Book Description

This volume of newly commissioned essays provides comprehensive coverage of African philosophy, ranging across disciplines and throughout the ages. Offers a distinctive historical treatment of African philosophy. Covers all the main branches of philosophy as addressed in the African tradition. Includes accounts of pre-colonial African philosophy and contemporary political thought.




Gene Drives on the Horizon


Book Description

Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.