Nonhuman Primate Models in Biomedical Research: State of the Science and Future Needs


Book Description

Nonhuman primates represent a small fraction of animals used in biomedical research, but they remain important research models due to their similarities to humans with respect to genetic makeup, anatomy, physiology, and behavior. Limitations in the availability of nonhuman primates have been exacerbated by the COVID-19 pandemic and recent restrictions on their exportation and transportation, impacting National Institutes of Health (NIH)-funded research necessary for both public health and national security. Additionally, there is continued interest in understanding whether and how nonanimal models can be used to answer scientific questions for which nonhuman primates are currently used. At the direction of the U.S. Congress, NIH asked the National Academies of Sciences, Engineering, and Medicine to convene an expert committee to conduct a landscape analysis of current and future use of nonhuman primates in NIH-supported biomedical research, as well as opportunities for new approach methodologies to complement or reduce reliance on nonhuman primate models. This report provides the committee findings and conclusions.




Nonhuman Primates and Medical Research


Book Description

Nonhuman Primates and Medical Research focuses on the contributions of nonhuman primates to biomedical research. The selection first elaborates on monkeys and yellow fever, cell cultures, and tuberculosis and bacterial infection. Discussions focus on bacterial diseases, tuberculosis, radiobiology, antibody formation and pharmacologic studies, cell-culture media and methods, the rhesus monkey and early history of yellow fever research, and monkeys and yellow fever in the future. The text then elaborates on virus research, models for investigation in parasitology, and primates as organ donors in transplantation studies in man. The manuscript examines the importance of monkeys for the study of malignant tumors in man; use of primates in cardiovascular research; and humanlike diseases in anthropoid apes. Topics include etiology of humanlike disease in anthropoid apes, atherosclerosis, historical aspects of primate research, selection of a suitable primate, and preeclampsia. The text also ponders on primate studies and human evolution and mental retardation. The selection is a valuable reference for researchers interested in the contributions of nonhuman primates to biomedical research.




Nonhuman Primates in Biomedical Research


Book Description

A comprehensive, up-to-date review of the use of nonhuman primates in biomedical research, emphasising the biology and management, diseases, and biomedical models for nonhuman primate species most commonly used in research.







Nonhuman Primates


Book Description




Nonhuman Primates in Biomedical Research


Book Description

The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The Biology and Management volume provides basic information on the natural biology of nonhuman primates and the current state of knowledge regarding captive management. Each chapter contains an extensive list of bibliographic references, photographs, and graphic illustrations to provide the reader with a thorough review of the subject. - Now in four color throughout, making the book more visually stimulating to enhance learning and ease of use - Fully revised and updated, providing researchers with the most comprehensive review of the use of nonhuman primates in biomedical research - Addresses commonly used nonhuman primate biomedical models, providing researchers with species-specific information




Occupational Health and Safety in the Care and Use of Nonhuman Primates


Book Description

The field of occupational health and safety constantly changes, especially as it pertains to biomedical research. New infectious hazards are of particular importance at nonhuman-primate facilities. For example, the discovery that B virus can be transmitted via a splash on a mucous membrane raises new concerns that must be addressed, as does the discovery of the Reston strain of Ebola virus in import quarantine facilities in the U.S. The risk of such infectious hazards is best managed through a flexible and comprehensive Occupational Health and Safety Program (OHSP) that can identify and mitigate potential hazards. Occupational Health and Safety in the Care and Use of Nonhuman Primates is intended as a reference for vivarium managers, veterinarians, researchers, safety professionals, and others who are involved in developing or implementing an OHSP that deals with nonhuman primates. The book lists the important features of an OHSP and provides the tools necessary for informed decision-making in developing an optimal program that meets all particular institutional needs.




Nonhuman Primates in Biomedical Research


Book Description

Nonhuman Primates in Biomedical Research: Biology and Management represents the most comprehensive publication of its type on nonhuman primates. It also provides basic information on the biology and management of primates for anyone responsible for the care and use of these animals. A related book on primate diseases will be published in 1996. - Stresses the following major topics: - Biology and medical management - Reproductive physiology and breeding - Nutrition - Biohazards