Toxicological Profile for DDT/DDD/DDE (Update)


Book Description

DDT is a pesticide that was once widely used to control insects. Both DDD and DDE are breakdown products of DDT. This profile includes: (1) The examination, summary, and interpretation of available toxicologic info. and epidemiologic evaluations on DDT/DDD/DDE to ascertain the levels of significant human exposure for the substance and the associated chronic health effects; (2) A determination of whether adequate info. on the health effects of DDT/DDD/DDE is available to determine levels of exposure that present a significant risk to human health of chronic health effects; and (3) Identification of toxicologic testing needed to identify the types or levels of exposure that may present significant risk of adverse health effects in humans. Illus.




Taking an Exposure History


Book Description













How Tobacco Smoke Causes Disease


Book Description

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.




Boron


Book Description

This book evaluates the risks to human health and the environment posed by boron, a naturally occurring element widely distributed in the form of various inorganic borates in the oceans, sedimentary, rocks, coal, shale and some soils. Boron is also used in laundry bleach and in the manufacture of glass, glass products, fertilizers and herbicides, antiseptics, and pharmaceuticals. Since boron is widely detected in drinking-water and occurs naturally in fruits, nuts, and vegetables, the report gives particular attention to health risks associated with exposure of the general population through diet and drinking-water.A section on sources of human and environmental exposure cites evidence that boron enters the environment mainly through volatilization from seawater, volcanoes, geothermal steam, and natural weathering of clay-rich sedimentary rock. Although industrial uses account for much smaller releases, the report notes that all of the boron from the sodium perborate contained in detergents ultimately enters the wastewater system, and is not removed by standard water treatment procedures.