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Venoms to Drugs

Author : Glenn F. King

Publisher : Royal Society of Chemistry

Page : 308 pages

File Size : 38,26 MB

Release : 2015-01-27

Category : Science

ISBN : 1782624376

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Book Description

The pharmaceutical industry has become increasingly interested in biologics from animal venoms as a potential source for therapeutic agents in recent years, with a particularly emphasis on peptides. To date six drugs derived from venom peptides or proteins have been approved by the FDA, with nine further agents currently being investigated in clinical trials. In addition to these drugs in approved or advanced stages of development, many more peptides and proteins are being studied in varying stages of preclinical development. This unique book provides an up to date and comprehensive account of the potential of peptides and proteins from animal venoms as possible therapeutics. Topics covered include chemistry and structural biology of animal venoms, proteomic and transcriptomic approaches to drug discovery, bioassays, high-throughput screens and target identification, and reptile, scorpion, spider and cone snail venoms as a platform for drug development. Case studies are used to illustrate methods and successes and highlight issues surrounding administration and other important lessons that have been learnt from the development of approved therapeutics based on venoms. The first text to focus on this fascinating area and bridging an important gap, this book provides the reader with essential and current knowledge on this fast-developing area. Venoms to Drugs will find wide readership with researchers working in academia and industry working in all medicinal and pharmaceutical areas.



Spider Venoms

Author : P. Gopalakrishnakone

Publisher : Springer

Page : 0 pages

File Size : 11,65 MB

Release : 2016-05-10

Category : Medical

ISBN : 9789400763883

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Book Description

In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively.



Toxins and Drug Discovery

Author : P. Gopalakrishnakone

Publisher : Springer

Page : 0 pages

File Size : 49,75 MB

Release : 2019-09-11

Category : Medical

ISBN : 9789400764514

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Book Description

In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively.



Venoms of the Hymenoptera

Author : Tom Piek

Publisher : Elsevier

Page : 583 pages

File Size : 45,36 MB

Release : 2013-10-22

Category : Medical

ISBN : 1483263703

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Book Description

Venoms of the Hymenoptera: Biochemical, Pharmacological, and Behavioral Aspects contains papers that deals with the study of the venoms and toxins produced by insects belonging to the order of the Hymenoptera. The book provides a considerable amount of information in the study of the venoms of the Hymenoptera. There are chapters that focus on the history of the research made on the order of the Hymenoptera; the stinging apparatus; venom collection; physiological effects of venoms produced by particular insects belonging to the order; and the pharmacological uses of the venoms and toxins. Entomologists, physiologists, pharmacologists, biochemists, and researchers developing drugs and pesticides will find this text extremely useful.





Venom

Author : Ronald Jenner

Publisher : Smithsonian Institution

Page : 207 pages

File Size : 12,64 MB

Release : 2017-10-17

Category : Nature

ISBN : 1588344541

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Book Description

Venom brings readers face to face with some of the most dangerous creatures on the planet, including jellyfish, snakes, and wasps, as it uncovers the story of venom. The book explores how venom is used for predation, defense, competition, and communication by an incredible diversity of species. It examines the unique methods that these species have evolved to create and deliver their deadly toxins. The book traces venom back to its origin in early jellyfish and sea anemones, and reveals how venoms have evolved dozens of times independently all across the animal kingdom since that time. And finally, it examines the relationships between these dangerous creatures and humans. Humans have not only learned to live with them, but also to benefit from them: scientists increasingly are harnessing the power of venom to create new drugs, treatments, and anti-venoms.



Scorpion Venoms

Author : P. Gopalakrishnakone

Publisher : Springer

Page : 550 pages

File Size : 21,17 MB

Release : 2021-01-14

Category : Medical

ISBN : 9789400766471

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Book Description

In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively.



Pills, Potions, and Poisons

Author : T. W. Stone

Publisher : Oxford University Press, USA

Page : 476 pages

File Size : 23,47 MB

Release : 2004

Category : Medical

ISBN : 9780198609421

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Book Description

About half of all the medicines prescribed by doctors are not taken by their patients. One of the reasons most commonly given by patients for not taking drugs is that they feel unhappy about taking medicines which they do not understand and of which they are afraid. This book attempts to rectify this problem by showing in clear, non-technical language how medicines and other drugs work in the body to reduce the effects of disease. Most chapters include fascinating background information on how some of our most important drugs were discovered, along with intriguing and often amusing anecdotes about the drugs and the people behind their discovery. Each chapter also includes a summary of the key points together with illustrations, photographs or diagrams to summarise the main groups and how they work in the body. The book covers all the major groups of drugs, with complete listings of all the drugs available in the UK and the USA, so that the reader can locate his or her specific drug and read about the actions of the drugs in that group. The various chapters cover drugs used to treat high blood pressure, heart disease, diabetes, nausea, vomiting, diarrhoea, constipation, ulcers, cancers, infections, impotence, incontinence, arthritis, osteoporosis, as well as hormone replacement therapy, oral contraceptives and drugs used in disorders of the brain such as schizophrenia, depression, Parkinson's disease, Alzheimer's disease and epilepsy. There is also a chapter on drugs which are abused such as cannabis, alcohol, nicotine and ecstasy, and a chapter covering some of the poisons we encounter, such as carbon monoxide, arsenic, sheep dip, and the venoms of snakes, spiders, scorpions and marine organisms. Here, then, a fascinating survey of how chemicals have their effects in the body. It shows how drugs work and explains why it is that taking some medicines for many years is far safer than suffering the long-term effects of disease. Pills, Potions and Poisons is an entertaining read that should also help to improve your health and quality of life.



The Age of Intoxication

Author : Benjamin Breen

Publisher : University of Pennsylvania Press

Page : 288 pages

File Size : 43,89 MB

Release : 2019-11-22

Category : History

ISBN : 0812296621

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Book Description

Eating the flesh of an Egyptian mummy prevents the plague. Distilled poppies reduce melancholy. A Turkish drink called coffee increases alertness. Tobacco cures cancer. Such beliefs circulated in the seventeenth and eighteenth centuries, an era when the term "drug" encompassed everything from herbs and spices—like nutmeg, cinnamon, and chamomile—to such deadly poisons as lead, mercury, and arsenic. In The Age of Intoxication, Benjamin Breen offers a window into a time when drugs were not yet separated into categories—illicit and licit, recreational and medicinal, modern and traditional—and there was no barrier between the drug dealer and the pharmacist. Focusing on the Portuguese colonies in Brazil and Angola and on the imperial capital of Lisbon, Breen examines the process by which novel drugs were located, commodified, and consumed. He then turns his attention to the British Empire, arguing that it owed much of its success in this period to its usurpation of the Portuguese drug networks. From the sickly sweet tobacco that helped finance the Atlantic slave trade to the cannabis that an East Indies merchant sold to the natural philosopher Robert Hooke in one of the earliest European coffeehouses, Breen shows how drugs have been entangled with science and empire from the very beginning. Featuring numerous illuminating anecdotes and a cast of characters that includes merchants, slaves, shamans, prophets, inquisitors, and alchemists, The Age of Intoxication rethinks a history of drugs and the early drug trade that has too often been framed as opposites—between medicinal and recreational, legal and illegal, good and evil. Breen argues that, in order to guide drug policy toward a fairer and more informed course, we first need to understand who and what set the global drug trade in motion.



Handbook of Venoms and Toxins of Reptiles

Author : Stephen P. Mackessy

Publisher : CRC Press

Page : 912 pages

File Size : 29,51 MB

Release : 2021-05-24

Category : Nature

ISBN : 0429623453

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Book Description

A decade after publication of the first edition, Handbook of Venoms and Toxins of Reptiles responds to extensive changes in the field of toxinology to endure as the most comprehensive review of reptile venoms on the market. The six sections of this new edition, which has nearly doubled in size, complement the original handbook by presenting current information from many of the leading researchers and physicians in toxinology, with topics ranging from functional morphology, evolution and ecology to crystallography, -omics technologies, drug discovery and more. With the recent recognition by the World Health Organization of snakebite as a neglected tropical disease, the section on snakebite has been expanded and includes several chapters dealing with the problem broadly and with new technologies and the promises these new approaches may hold to counter the deleterious effects of envenomation. This greatly expanded handbook offers a unique resource for biologists, biochemists, toxicologists, physicians, clinicians, and epidemiologists, as well as informed laypersons interested in the biology of venomous reptiles, the biochemistry and molecular biology of venoms, and the effects and treatment of human envenomation.