Viral and Mycoplasmal of Laboratory Rodents


Book Description

Viral and Mycoplasmal Infections of Laboratory Rodents: Effects on Biomedical Research contains the proceedings of a conference held at the National Institutes of Health on October 24-26, 1984. Organized into four parts, this book begins by elucidating the basic biology and pathogenetic mechanisms of viral and mycoplasmal infections. The presence of known and potential research complications due to these infections is also addressed. Lastly, the detection, control, and prevention of infection in rodent colonies are discussed.




Microbial and Phenotypic Definition of Rats and Mice


Book Description

US-Japan meetings on laboratory animal science have been held virtually every year since 1980 under the US-Japan Cooperative Program on Science and Technology. Over the years these meetings have resulted in a number of important documents including the Manual of Microbiologic of Monitoring of Laboratory Animals published in 1994 and the article Establishment and Preservation of Reference Inbred Strains of Rats for General Purposes published in 1991. In addition to these publications, these meetings have been instrumental in increasing awareness of the need for microbiologic monitoring of laboratory rodents and the need for genetic definition and monitoring of mice and rats.




Essentials of Laboratory Animal Science: Principles and Practices


Book Description

This book comprehensively reviews the anatomy, physiology, genetics and pathology of laboratory animals as well as the principles and practices of using laboratory animals for biomedical research.It covers the design of buildings used for laboratory animals, quality control of laboratory animals, and toxicology, and discusses various animal models used for human diseases. It also highlights aspects, such as handling and restraint and administration of drugs, as well as breeding and feeding of laboratory animals, and provides guidelines for developing meaningful experiments using laboratory animals.Further, the book discusses various alternatives to animal experiments for drug and chemical testing, including their advantages over the current approaches. Lastly, it examines the potential effect of harmful pathogens on the physiology of laboratory animals and discusses the state of art in in vivo imaging techniques.The book is a useful resource for research scientists, laboratory animal veterinarians, and students of laboratory animal medicine.




Molecular Biology and Pathogenicity of Mycoplasmas


Book Description

was the result of the efforts of Robert Cleverdon. The rapidly developing discipline of molecular biology and the rapidly expanding knowledge of the PPLO were brought together at this meeting. In addition to the PPLO specialists, the conference invited Julius Marmur to compare PPLO DNA to DNA of other organisms; David Garfinkel, who was one of the first to develop computer models of metabolism; Cyrus Levinthal to talk about coding; and Henry Quastler to discuss information theory constraints on very small cells. The conference was an announcement of the role of PPLO in the fundamental understanding of molecular biology. Looking back 40-some years to the Connecticut meeting, it was a rather bold enterprise. The meeting was international and inter-disciplinary and began a series of important collaborations with influences resonating down to the present. If I may be allowed a personal remark, it was where I first met Shmuel Razin, who has been a leading figure in the emerging mycoplasma research and a good friend. This present volume is in some ways the fulfillment of the promise of that early meeting. It is an example of the collaborative work of scientists in building an understanding of fundamental aspects of biology.




The Welfare of Laboratory Animals


Book Description

This book examines the general principles of laboratory animal maintenance and experimental use as well as factors that have to be taken into account when good research is done with animals. In addition, it provides species specific coverage, concentrating on the species most used as laboratory animals. The book gives a comprehensive description of the welfare questions considered to be important for each species under laboratory conditions.




Ferrets, Rabbits and Rodents - E-Book


Book Description

A concise guide to the care of small mammals, Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery covers the conditions seen most often in veterinary practice. The book emphasizes preventive medicine along with topics including disease management, ophthalmology, dentistry, and zoonosis. More than 400 illustrations demonstrate key concepts related to radiographic interpretation, relevant anatomy, and diagnostic, surgical, and therapeutic techniques. Now in full color, this edition adds coverage of more surgical procedures and expands coverage of zoonotic disease. From editors Katherine Quesenberry and James W. Carpenter, along with a team of expert contributors, the "Pink Book" provides an authoritative, single source of information that is hard to find elsewhere. A logical organization makes it quick and easy to find important information, with each section devoted to a single animal and chapters within each section organized by body system. Over 400 photographs and illustrations highlight key concepts such as radiographic interpretation and the main points of diagnostic, surgical, and therapeutic techniques. A chapter on ophthalmology provides hard-to-find information on eye care for ferrets, rabbits, rodents, and other small mammals. Coverage of preventive medicine includes basic biology, husbandry, and routine care of the healthy animal. The drug formulary supplies dosage instructions for ferrets, rabbits, guinea pigs, chinchillas, hamsters, rats/mice, prairie dogs, hedgehogs, and sugar gliders. Chapter outlines offer at-a-glance overviews of the contents of each chapter. Handy tables and charts make it easy to find key information. Expanded Zoonotic Diseases chapter adds more depth along with the latest information on the rising potential for disease transmission to humans as exotic pets become more popular. Additional surgical procedures for each species are included, some with step-by-step instructions accompanied by color photographs and line drawings. Full-color images show the sometimes minute structures of these small animals and make accurate diagnoses easier, especially for lymphoproliferative diseases of rabbits, endoscopy, cytology, and hematology.




The Laboratory Mouse


Book Description

Mice have long been recognized as a valuable tool for investigating the genetic and physiological bases of human diseases such as diabetes, infectious disease, cancer, heart disease, and a wide array of neurological disorders. With the advent of transgenic and other genetic engineering technologies, the versatility and usefulness of the mouse as a







Management of Animal Care and Use Programs in Research, Education, and Testing


Book Description

AAP Prose Award Finalist 2018/19 Management of Animal Care and Use Programs in Research, Education, and Testing, Second Edition is the extensively expanded revision of the popular Management of Laboratory Animal Care and Use Programs book published earlier this century. Following in the footsteps of the first edition, this revision serves as a first line management resource, providing for strong advocacy for advancing quality animal welfare and science worldwide, and continues as a valuable seminal reference for those engaged in all types of programs involving animal care and use. The new edition has more than doubled the number of chapters in the original volume to present a more comprehensive overview of the current breadth and depth of the field with applicability to an international audience. Readers are provided with the latest information and resource and reference material from authors who are noted experts in their field. The book: - Emphasizes the importance of developing a collaborative culture of care within an animal care and use program and provides information about how behavioral management through animal training can play an integral role in a veterinary health program - Provides a new section on Environment and Housing, containing chapters that focus on management considerations of housing and enrichment delineated by species - Expands coverage of regulatory oversight and compliance, assessment, and assurance issues and processes, including a greater discussion of globalization and harmonizing cultural and regulatory issues - Includes more in-depth treatment throughout the book of critical topics in program management, physical plant, animal health, and husbandry. Biomedical research using animals requires administrators and managers who are knowledgeable and highly skilled. They must adapt to the complexity of rapidly-changing technologies, balance research goals with a thorough understanding of regulatory requirements and guidelines, and know how to work with a multi-generational, multi-cultural workforce. This book is the ideal resource for these professionals. It also serves as an indispensable resource text for certification exams and credentialing boards for a multitude of professional societies Co-publishers on the second edition are: ACLAM (American College of Laboratory Animal Medicine); ECLAM (European College of Laboratory Animal Medicine); IACLAM (International Colleges of Laboratory Animal Medicine); JCLAM (Japanese College of Laboratory Animal Medicine); KCLAM (Korean College of Laboratory Animal Medicine); CALAS (Canadian Association of Laboratory Animal Medicine); LAMA (Laboratory Animal Management Association); and IAT (Institute of Animal Technology).




Gnotobiotics


Book Description

Gnotobiotics summarizes and analyzes the research conducted on the use of gnotobiotes, providing detailed information regarding actual facility operation and derivation of gnotobiotic animals. In response to the development of new tools for microbiota and microbiome analysis, the increasing recognition of the various roles of microbiota in health and disease, and the consequent expanding demand for gnotobiotic animals for microbiota/microbiome related research, this volume collates the research of this expanding field into one definitive resource. - Reviews and defines gnotobiotic animal species - Analyzes microbiota in numerous contexts - Presents detailed coverage of the protocols and operation of a gnotobiotic facility