Author : World Health Organization
Publisher : World Health Organization
Page : 48 pages
File Size : 36,12 MB
Release : 2022-10-25
Category : Medical
ISBN : 9240060243
Author : Peter Admirand
Publisher : Rowman & Littlefield
Page : 251 pages
File Size : 12,15 MB
Release : 2024-05-29
Category : Religion
ISBN : 1978716362
With a catastrophic fungal pandemic, the post-apocalypse, a moral quest despite societal breakdowns, humans hunting humans or morphed into grotesque infected, The Last of Us video games and HBO series have exhilarated, frightened, and broken the hearts of millions of gamers and viewers. The Last of Us and Theology: Violence, Ethics, Redemption? is a richly diverse and probing edited volume featuring essays from academics across the world to examine theological and ethical themes from The Last of Us universe. Divided into three groupings—Violence, Ethics, and Redemption?—these chapters will especially appeal to The Last of Us fans and those interested in Theology and Pop Culture more broadly. Chapters not only grapple with theologians, ethicists, and novelists like Cormac McCarthy, Fyodor Dostoevsky, Martin Buber, and Paul Tillich; and theological issues from forgiveness and theodicy to soteriology and eschatology; but will help readers become experts on all things fireflies, clickers, Cordyceps, and Seraphites. “Save who you can save” and “Look for the Light.”
Author : Subhash Chandra Parija
Publisher : Springer Nature
Page : 356 pages
File Size : 31,18 MB
Release :
Category :
ISBN : 981973214X
Author : Susanna Valanne
Publisher : Frontiers Media SA
Page : 116 pages
File Size : 13,84 MB
Release : 2024-06-26
Category : Medical
ISBN : 2832550835
The fruit fly Drosophila melanogaster is an established tool to study mechanisms of innate immunity. Drosophila flies and larvae launch elegant humoral and cellular innate immune responses against bacteria, viruses, fungi and parasites. The humoral immune response is based on microbial recognition primarily by peptidoglycan recognition proteins leading to the production of antimicrobial peptides (AMPs). In the past few decades, Drosophilists have dissected how flies react to systemic bacterial and fungal infections at the molecular level and shown how these mechanisms are conserved from human to man. Fly humoral immune response is mainly mediated by two evolutionarily conserved NF-κB signaling pathways, the Toll and the Immune deficiency (Imd) pathways. The discovery of the Toll receptor as a key regulator of immune response, first in cultured Drosophila cells and then in Drosophila in vivo, formed the basis of the Toll-Like Receptor (TLR) research in humans and mammals. More recently, this field has broadened considerably, including e.g. the antimicrobial responses taking place in the gut. Another interesting aspect related to innate immunity is the antiviral immune mechanisms found in Drosophila. Best understood are the mechanisms based on RNAi, primarily against RNA virus infections. More recently, the evolutionarily conserved molecule STING has been shown to integrate responses against both viruses and bacteria.
Author : Nancy Tkacs, PhD, RN
Publisher : Springer Publishing Company
Page : 1048 pages
File Size : 36,5 MB
Release : 2024-03-22
Category : Medical
ISBN : 0826167543
2020 AJN Book-of-the-Year Award Winner: Advanced Practice Nursing! Concise and well-organized, this advanced physiology and pathophysiology text promotes deep understanding of key pathophysiological concepts and relates them to major disorders commonly seen in practice. It is distinguished by its stellar organization and writing that clarifies difficult-to-understand disease mechanisms. The second edition offers several new features that add to its value in preparing the student clinician to care for patients with a broad variety of disorders effectively. The second edition retains the inclusive language and conceptual organization central to the appeal and usefulness of the first edition. Coverage of new scientific advances update the original disease descriptions. With the aim of preparing students to be well-informed and confident decision makers in primary care settings, the text provides the key knowledge required to master pharmacology for prescriptive practice. Addressing both healthy organ function and disease-associated changes, it details and illustrates the cellular structure and function of each organ system and mechanisms of associated major clinical disorders. It examines the reasons patients often present with particular symptoms, the rationale for ordering specific diagnostic tests and interpretation of the results, and common management strategies that proceed from the underlying pathology. The text is replete with case presentations to illustrate concepts, over 500 images, key points at the end of each chapter to reinforce knowledge, and a glossary defining correct terminology. Comprehensive instructor resources accompany the text. New to the Second Edition: Standardized template for pediatric and gerontology content for clarity Expanded coverage of neonatal and pediatric development and vulnerabilities Methylation patterns of cell-free DNA (epigenetics) in oncology practice Expanded coverage of fluid and electrolyte balance Physiology of pregnancy, labor, and delivery Increased content on the social determinants of health Introduction of the exposome concept in human disease New content on biological and psychosocial aspects of human sexual development and variations relevant to LGBTQ+ centered care COVID-19-related concerns Key Features: Includes comprehensive lifespan considerations with key insights from specialists in pediatric and geriatric pathophysiology Integrates critical thinking questions and case studies to promote discussion and information synthesis Provides unique Bridge to Clinical Practice in each chapter to translate science to practical patient care Includes more than 500 images to illustrate complex scientific concepts Summarizes content with key points at the end of each chapter
Author : Erin E. McClelland
Publisher : Springer Nature
Page : 414 pages
File Size : 21,6 MB
Release : 2024
Category : Cryptococcus neoformans
ISBN : 1071637223
This volume explores the latest developments in the study of Cryptococcus neoformans and its pathology, along with discussion on newly used therapeutics. The chapters in this book cover a wide range of protocols commonly used in Cryptococcus research such as animal models, genetics techniques, virulence factor phenotyping, and microscopy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Cryptococcus neoformans: Methods and Protocols is a valuable resource that will help researchers further enhance their understanding of this pathogenic yeast, and will aid in new discoveries and therapeutics. .
Author : Fingani Mphande
Publisher : Springer Nature
Page : 151 pages
File Size : 40,83 MB
Release : 2023-08-04
Category : Social Science
ISBN : 9819942543
This book highlights lessons from the COVID-19 pandemic and explains how these can be used to build sustainable health systems, especially in Low- and Middle-Income Countries (LMIC). It investigates the impact of outbreak response and management on health sustainability in LMIC from the perspective of SDG3: “Ensuring healthy lives and wellbeing for all at all ages”. Despite strides being made in some areas for SDG target 3.3 to fight communicable diseases, the COVID-19 pandemic has caused interruptions that will considerably affect vaccination coverage as well as the progress that was made, for example: in reducing malaria cases. Vulnerable populations who were already struggling to access their healthcare needs before the pandemic may face even greater challenges at present and in the years to come, post-pandemic. This book considers the progress on attaining the SDG3 targets, specifically: to improve early warning systems for management of national and global health risks, and the effect of pandemics - including but not limited to the COVID-19 pandemic - and emerging disease outbreaks. It explores the weaknesses and strengths in LMIC and how to strengthen capacities in these countries. The author also investigates and proposes approaches that can, or should, be implemented to ensure sustainable health systems in developing countries, including early warning systems, risk reduction, and the management of global and national health risks. This book is of great interest to public health professionals, infectious diseases experts, and epidemiologists, as well as students and researchers of public health systems and healthcare infrastructure in developing countries.
Author : Rajesh Chandra Mishra
Publisher : Jaypee Brothers Medical Publishers
Page : 632 pages
File Size : 18,8 MB
Release : 2023-02-22
Category : Medical
ISBN : 9356961530
SECTION 1: Sepsis Diagnosis and Management 1. Precision Medicine in Septic Shock 2. Optimal Blood Pressure Target in Patients with Septic Shock 3. The Surviving Sepsis Campaign Guidelines in 2022: What is New and what has Changed? 4. Individualizing Hemodynamics in Septic Shock 5. Adjunctive Therapies in Sepsis: Current Status 6. Refractory Septic Shock: What are the Options 7. Steroids in Sepsis and Clinical Outcomes 8. Candida auris: Detection, Prevention, and Management 9. Empirical Antifungal Treatment: Is It Justified? 10. Role of Steroids in Severe Community acquired Pneumonia 11. Procalcitonin: Can It Differentiate Bacterial versus Fungal Infection SECTION 2: Antimicrobial Therapy in ICU 12. Optimizing Antimicrobial Dosing in the Intensive Care Unit 13. Antibiotic within 1 hour: Should this be Applied to all Patients with Sepsis? 14. Dark Side of Antibiotics 15. Optimal Duration of Antibiotic Therapy 16. Cefiderocol: Is this the Answer to Multidrug-resistant Gram-negative Infection? SECTION 3: Respiratory Critical Care 17. Management of Pneumonia in Intensive Care 18. Reverse Triggering during Controlled Ventilation: A Frequent Dysynchrony with Various Consequences 19. Use of Multiplex Polymerase Chain Reaction in Pneumonia 20. Management of Complicated Pleural Effusion 21. Hepatic Hydrothorax 22. Submassive Pulmonary Embolism 23. Role of Magnesium in Respiratory Failure 24. ARDS in Children: How is it Different? 25. Safe Tracheal Intubation in Intensive Care Unit 26. Lateral Positioning: Does it Work? 27. Dyspnea in Patients on Invasive Ventilation: Clinical Impact 28. Complications of Noninvasive Ventilation Failure SECTION 4: Mechanical Ventilation 29. Setting Optimum PEEP 30. Open Lung or Keep Lung Closed: Which Strategy to Choose? 31. Driving Pressure or Mechanical Power: Which One to Monitor? 32. Measuring Respiratory Drive and Muscle Effort 33. Oxygenation Targets in Mechanically Ventilated Critically-ill Patients 34. Ventilatory Ratio: A New Monitoring Tool 35. Helmet NIV: Is it a Game Changer? 36. Electrical Impedance Tomography: Current Application 37. Automatic Tube Compensation: Does it have a Role? 38. High-frequency Oscillatory Ventilation in Pediatric Acute Respiratory Distress Syndrome 39. Noninvasive Ventilation in Pediatrics: Current Status SECTION 5: Cardiovascular Critical Care 40. Crystalloid Resuscitation: Finding the Balance 41. Artificial Intelligence Tools to Optimize Hemodynamics in the ICU 42. Aggressive or Restrictive Fluid Resuscitation 43. Predicting Hypotension: Is It Useful? 44. Vasopressors: How Early? 45. Myocardial Injury after Noncardiac Surgery 46. Use of Vasopressin during Cardiac Arrest SECTION 6: Echocardiography and Ultrasound 47. Advances in Intensive Care Unit Echocardiography 48. Transesophageal Echocardiography: Is It Preferable in the Intensive Care Unit? 49. ECHO Features of Pulmonary Hypertension and Increased Left Atrial Pressures 50. Role of Echocardiography in Shock State 51. Use of Echocardiography in Assessing Fluid Responsiveness 52. Venous Excess Ultrasound Score (VExUS) SECTION 7: Nephrology, Fluids, Acid-Base Balance and Electrolytes Balance 53. Fluid Management in Acute Kidney Injury 54. Sepsis-associated Acute Kidney Injury: Common but Poorly Understood 55. Delayed versus Very Delayed Renal Replacement Therapy 56. Plasma Exchange in Intensive Care Unit: Current Status 57. Acute Kidney Injury Care Bundle 58. Biomarker-driven Therapy in AKI 59. How to Approach Dyselectrolytemias in a Patient on CRRT? SECTION 8: Neurocritical Care 60. Prognostication in
Author :
Publisher : World Health Organization
Page : 18 pages
File Size : 49,78 MB
Release : 2020-05-04
Category : Medical
ISBN : 9240006354
Author : Varvara K. Kozyreva
Publisher : Frontiers Media SA
Page : 147 pages
File Size : 18,87 MB
Release : 2024-02-05
Category : Medical
ISBN : 2832544193
The expansion of NGS implementation in clinical and public health practice accelerated drastically during the SARS-CoV-2 pandemic, where NGS has been playing a vital role in tracking dangerous strains of the virus. NGS applications not only influenced public health decision-making but also have been crossing into the clinical field with individual patients’ results being potentially available to the physicians. Hence, the topic of implementation of NGS methods in clinical and public health microbiology, its challenges and special considerations, is as timely as ever. The use of Next Generation Sequencing (NGS) in clinical and public health microbiology laboratories has been steadily expanding in the past decade. However, this progress has been held back by multiple logistical challenges, like the absence of regulatory compliance framework, lack of clear quality guidelines, the need for standardization and interoperability between laboratories, as well as cost and turn-around-time limitations.
