Bioactive Lipids


Book Description

In Bioactive lipids, Anna Nicolaou and George Kokotos have brought together an international team of authors to discuss the nomenclature, structures, biochemistry, pharmacology and recent developments in the main classes of bioactive lipids. These lipids are essential components of the cell membrane and play many dynamic roles in mediating and controlling a wide array of cellular activities including membrane structure and organization, metabolic and gene regulation, protein structure and function, energy production, and signalling pathways. The lipid interests of scientists in the pharmaceutical and food industries are converging as the broader significance of bioactive lipids is increasingly recognized. Lipids and lipid-metabolizing enzymes are targeted for the development of new drugs. Meanwhile, functional foods, nutraceuticals and supplements already have lipids as major active ingredients. The food industry will progress from simply using lipids as ingredients, to the formulation of products that influence the synthesis, metabolism and effects of bioactive lipids in the body. These advances in applied lipid biochemistry will build on the fundamental research of lipid scientists in universities worldwide, such as those scientists contributing to Bioactive lipids.




Lipoxygenases and Their Products


Book Description

Lipoxygenases and Their Products provides a cogent summary of the advances in understanding lipoxygenases and their products, emphasizing their pharmacology and pathophysiology; regulation and structure; physiological role; and receptors and receptor antagonists. This text also reviews the literature where specific receptor antagonists (as opposed to enzymatic inhibitors) have been used to characterize the pharmacologic action and the pathophysiologic roles of some of lipoxygenase products of arachidonic acid metabolism. This book is organized into 11 chapters and begins with an overview of th ...




Lipid Oxidation


Book Description

In this second edition, Edwin Frankel has updated and extended his now well-known book Lipid oxidation which has come to be regarded as the standard work on the subject since the publication of the first edition seven years previously. His main objective is to develop the background necessary for a better understanding of what factors should be considered, and what methods and lipid systems should be employed, to achieve suitable evaluation and control of lipid oxidation in complex foods and biological systems. The oxidation of unsaturated fatty acids is one of the most fundamental reactions in lipid chemistry. When unsaturated lipids are exposed to air, the complex, volatile oxidation compounds that are formed cause rancidity. This decreases the quality of foods that contain natural lipid components as well as foods in which oils are used as ingredients. Furthermore, products of lipid oxidation have been implicated in many vital biological reactions, and evidence has accumulated to show that free radicals and reactive oxygen species participate in tissue injuries and in degenerative disease. Although there have been many significant advances in this challenging field, many important problems remain unsolved. This second edition of Lipid oxidation follows the example of the first edition in offering a summary of the many unsolved problems that need further research. The need to understand lipid oxidation is greater than ever with the increased interest in long-chain polyunsaturated fatty acids, the reformulation of oils to avoid hydrogenation and trans fatty acids, and the enormous attention given to natural phenolic antioxidants, including flavonoids and other phytochemicals.




Seed Proteins


Book Description

Seeds provide more than half of the world's intake of dietary protein and energy and thus are of immense economic, cultural and nutritional importance. Proteins can account for up to 40% of the dry weight of various types of seeds, thereby making a large contribution to the nutritional quality and processing properties of seeds. It is, therefore, not surprising that seed proteins were among the first plant components to be systematically studied, some 250 years ago, and have been a major focus of research over the past 100 years. The properties and behaviour of seed proteins pervade modem life in numerous ways. For example, legume and cereal proteins are used'in the production of a wide range of meat-free foods; the process of bread-making is dep~ndent on the physical chemical properties of wheat seed proteins; and in developed, as well as developing, countries, nutritional deficiencies among vegetarian diets are avoided through balancing legume and cereal seeds as sources of dietary proteins. Understanding seed proteins, in order to improve their composition and properties and to increase their concentrations, will thus continue to be an important research objective for the future. The present volume represents the culmination of a long-discussed plan of the editors, to bring together the best international authorities in order to compile a definitive monograph on biological, biochemical, molecular and genetic aspects of seed proteins.




Autoxidation in Food and Biological Systems


Book Description

The material presented in this book deals with basic mechanisms of free radical reactions in autoxidation processes and anitoxidant suppression of autoxidation of foods, biochemical models and biologi cal systems. Autoxidation in foods and corresponding biological effects are usually approached separately although recent mechanistic developments in the biochemistry and free radical chemistry of per oxides and their precursors tend to bring these two fields closer. Apparent ability of antioxidants in diets to reduce the inci dence of cancer has resulted in scrutiny of autoxidized products and their precursors as possibly toxic, mutagenic and carcinogenic agents. Mechanisms of any of these effects have been barely ad dressed. Yet we know now that free radicals, as esoteric as they were only a few decades ago, are being discovered in foods, biochem ical and biological systems and do play a role in the above-mentioned causalities. The purpose of the Workshop and the resulting book was to give a unifying approach towards study of beneficial and deleterious effects of autoxidation, based on rigorous scientific considerations. It is our hope that the material presented in this book will not only provide a review of the "state of the art" of autoxidation and anti oxidants, but also reflect the interaction which occurred during the Workshop between workers using model sytems, and food and biological systems.




The Endothelium


Book Description

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References




Biochemistry of Lipids, Lipoproteins and Membranes


Book Description

Biochemistry of Lipids: Lipoproteins and Membranes, Volume Six, contains concise chapters that cover a wide spectrum of topics in the field of lipid biochemistry and cell biology. It provides an important bridge between broad-based biochemistry textbooks and more technical research publications, offering cohesive, foundational information. It is a valuable tool for advanced graduate students and researchers who are interested in exploring lipid biology in more detail, and includes overviews of lipid biology in both prokaryotes and eukaryotes, while also providing fundamental background on the subsequent descriptions of fatty acid synthesis, desaturation and elongation, and the pathways that lead the synthesis of complex phospholipids, sphingolipids, and their structural variants. Also covered are sections on how bioactive lipids are involved in cell signaling with an emphasis on disease implications and pathological consequences. - Serves as a general reference book for scientists studying lipids, lipoproteins and membranes and as an advanced and up-to-date textbook for teachers and students who are familiar with the basic concepts of lipid biochemistry - References from current literature will be included in each chapter to facilitate more in-depth study - Key concepts are supported by figures and models to improve reader understanding - Chapters provide historical perspective and current analysis of each topic




Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4


Book Description

This book contains conference presentations regarding the regulation of eicosanoid enzymes and, in particular, cyclooxygenases, lipoxygenases, and phospholipases. The new field of isoprostanes is also represented.




Essential Fatty Acids and Eicosanoids


Book Description

Papers from the March 1992 conference explore the importance of EFA and eicosanoids on living organisms. Organization is around five interrelated themes: examination of the biological function of docosahexaenoic acid at the fundamental level of molecular and cellular research; biosynthesis of PUFA in mammals; types of biological markers that can provide information about the adequacy of EFA intake; role that EFA and eicosanoids play in the development of disease states; and in the nutrition of the fetus and newly born infants, especially those born prematurely. Member price, $100. Annotation copyright by Book News, Inc., Portland, OR




Lipoxygenases and their Metabolites


Book Description

This book is a result of the First Conference on Lipoxygenases, held at Malta, May 17th-2l st, 1997. The goal was very ambitious: having lipoxygenases as a focus for distant and diverse experimental approaches, we brought together scientists to discuss and build a consensus on the biological role of lipoxygenases. Although still fuzzy in many details, the Malta conference has shown that a unifying view on lipoxygenases is finally taking shape, and that the experimental evidence of links and conjugations among events OCCUf ing from cell membranes to intracellular compartments and the nucleus is becoming in creasingly convincing. The editors are deeply grateful to Hospital for Sick Children, Toronto, Free Univer sity Berlin, NOAA Sea Grant College Program (U. S. A. ), Schering, Berlin (F. R. G. ), and Cayman Chemicals, Ann Arbor, Michigan (U. S. A. ), for their generous financial support, which was crucial in making the conference a scientific success. The conference received financial support from a number of additional sponsors, and we express our gratitude to Abbott Labs (U. S. A. ), Air Malta (Malta), Ass. Int. Cancer Res. (U. K. ), Biometra (F. R. G. ), Bayer AG (F. R. G. ), IBL Co. (F. R. G. ), Merck Frosst (Canada), Perkin Elmer (F. R. G. ), Scotia Pharmaceuticals (Canada), Searle (U. S. A. ), SPI Chemicals (France), and TOPCRO (Austria).