Pharmacological Approaches to the Treatment of Brain and Spinal Cord Injury


Book Description

Although there are over 400,000 people each year in the United States alone who suffer from traumatic injury to the central nervous system (CNS), no phar macological treatment is currently available. Considering the enormity of the problem in terms of human tragedy as well as the economic burden to families and societies alike, it is surprising that so little effort is being made to develop treatments for these disorders. Although no one can become inured to the victims of brain or spinal cord injuries, one reason that insufficient time and effort have been devoted to research on recovery is that it is a generally held medical belief that nervous system injuries are simply not amenable to treatment. At best, current therapies are aimed at providing symptomatic relief or focus on re habilitative measures and the teaching of alternative behavioral strategies to help patients cope with their impairments, with only marginal results in many cases. Only within the last decade have neuroscientists begun to make serious inroads into understanding and examining the inherent "plasticity" found in the adult CNS. Ten years or so ago, very few researchers or clinicians would have thought that damaged central neurons could sprout new terminals or that intact nerve fibers in a damaged pathway could proliferate to replace inputs from neurons that died as a result of injury.




International Perspectives on Spinal Cord Injury


Book Description

"Every year between 250 000 and 500 000 people suffer a spinal cord injury, with road traffic crashes, falls and violence as the three leading causes. People with spinal cord injury are two to five times more likely to die prematurely. They also have lower rates of school enrollment and economic participation than people without such injuries. Spinal cord injury has costly consequences for the individual and society, but it is preventable, survivable and need not preclude good health and social inclusion. Ensuring an adequate medical and rehabilitation response, followed by supportive services and accessible environments, can help minimize the disruption to people with spinal cord injury and their families. The aims of International perspectives on spinal cord injury are to: --assemble and summarize information on spinal cord injury, in particular the epidemiology, services, interventions and policies that are relevant, together with the lived experience of people with spinal cord injury; --make recommendations for actions based on this evidence that are consistent with the aspirations for people with disabilities as expressed in the Convention on the Rights of Persons with Disabilities.




Diseases of the Brain, Head and Neck, Spine 2020–2023


Book Description

This open access book offers an essential overview of brain, head and neck, and spine imaging. Over the last few years, there have been considerable advances in this area, driven by both clinical and technological developments. Written by leading international experts and teachers, the chapters are disease-oriented and cover all relevant imaging modalities, with a focus on magnetic resonance imaging and computed tomography. The book also includes a synopsis of pediatric imaging. IDKD books are rewritten (not merely updated) every four years, which means they offer a comprehensive review of the state-of-the-art in imaging. The book is clearly structured and features learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers navigate the text. It will particularly appeal to general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic expertise, as well as clinicians from other specialties who are interested in imaging for their patient care.




Spinal Cord Injury Rehabilitation


Book Description

One of the world’s leading authorities in spinal cord injury, and a participant in the Human Brain Project brings you an evidenced-based guide to the state-of-the-art in spinal cord rehabilitation. She has assembled an expert team of clinicians, each with expertise in the content areas they address. Their work encompasses all of the new scientific knowledge and technological advances practitioners need to know to determine the most effective rehabilitation interventions for each patient and to attain maximum restoration of function in individuals with SCI.




Surgery of the Spinal Cord


Book Description

Selected papers from the prestigious Stonwin Medical Conference, which each summer invites a small group of neurosurgical investigation. This volume presents recent advances in research and practice of surgery of the severed spinal cord. Future volumes will treat similarly focused, cutting-edge topics. In terms of editorial strategy, this series will afford Springer entree to a select groups of neurosurgeons.







Spinal Cord Injury (SCI) Repair Strategies


Book Description

Spinal Cord Injury (SCI) Repair Strategies provides researchers the latest information on potential regenerative approaches to spinal cord injury, specifically focusing on therapeutic approaches that target regeneration, including cell therapies, controlled drug delivery systems, and biomaterials. Dr. Giuseppe Perale and Dr. Filippo Rossi lead a team of authoritative authors in academia and industry in this innovative reference on the field of regenerative medicine and tissue engineering. This book presents all the information readers need to understand the current and potential array of techniques, materials, applications and their benefits for spinal cord repair. Covers current and future repair strategies for spinal cord injury repair Focuses on key research trends, clinics, biology and engineering Provides fundamentals on regenerative engineering and tissue engineering




Restorative Neurology of Spinal Cord Injury


Book Description

Following injury or disease, neural circuitry can be altered to varying degrees leading to highly individualized characteristics that may or may not resemble original function. In addition, lost or partially damaged circuits and the effects of biological recovery processes coupled with learned compensatory strategies create a new neuroanatomy with capabilities that are often not functional or may interfere with daily life. To date, the majority of approaches used to treat neurological dysfunction have focused on the replacement of lost or damaged function, usually through the suppression of surviving neural activity and the application of mechanical assistive devices. Restorative Neurology of Spinal Cord Injury offers a different and novel approach. Focusing on the spinal cord and its role in motor control, the book details the clinical and neurophysiological assessment process and methods developed throughout the past half century by basic and clinical scientists. Then, through the use of specialized clinical and neurophysiological testing methods, conduction and processing performed within the surviving neural circuitry is examined and characterized in detail. Based on the results of such assessment, treatment strategies, also described in this book, are applied to augment, rather than replace, the performance of surviving neural circuitry and improve the functional capacity of people who have experienced injury to their spinal cords.




Living with Spinal Cord Injury


Book Description

The definitive guide for dealing with the major challenges those with spinal cord injuries face Medical advances have made it possible for those with spinal cord injuries to live an essentially normal life span' and to lead full' meaningful and productive lives. Inevitably' however' spinal injury superimposes special considerations on the routine activities and passages of life' and activities that might once have been easy can in many cases become increasingly difficult. This book identifies medical and nonmedical problems that individuals with SCI face as they get older' while providing practical advice on how to tackle these challenges. Includes information on health finances social support system the effects of aging.