A Lethal Inheritance


Book Description

Every family has secrets; only some secrets are lethal. In Victoria Costello’s family mental illness had been given many names over at least four generations until this inherited conspiracy of silence finally endangered the youngest members of the family, her children. In this riveting story—part memoir, detective story, and scientific investigation—the author recounts how the mental unraveling of her seventeen-year-old son Alex compelled her to look back into family history for clues to his condition. Eventually she tied Alex’s descent into hallucinations and months of shoeless wandering on the streets of Los Angeles to his great grandfather’s suicide on a New York City railroad track in 1913. But this insight brought no quick relief. Within two years of Alex’s diagnosis of paranoid schizophrenia, both she and her youngest son succumbed to two different mental disorders: major depression and anxiety disorder. Costello depicts her struggle to get the best possible mental health care for her sons and herself, treatment that ultimately brings each of them to full recovery. In the process, she discovers new science that explains how clusters of mental illness traverse family generations. Artfully weaving the scientific into the personal, Costello takes a journey to the far reaches of neuroscience and reports back on the startling findings it is yielding about the complex interplay between genes and environment that drives mental illness, and what it now tells us about how parents can trump a lethal inheritance. She shares the results of long-term U.K. and European family studies identifying the earliest signs of mental illnesses that can be passed on from grandparents to parents and grandchildren. She tracks ongoing clinical trials to reverse the courses of these diseases through early intervention with the latest evidence-based treatments and offers brain-healthy choices individuals and families can make to prevent mental illness—freeing future generations to live healthier, happier lives.




The Inheritance


Book Description

This gripping story of the doctors at the forefront of Alzheimer’s research and the courageous North Dakota family whose rare genetic code is helping to understand our most feared diseases is “excellent, accessible...A science text that reads like a mystery and treats its subjects with humanity and sympathy” (Library Journal, starred review). Every sixty-nine seconds, someone is diagnosed with Alzheimer’s disease. Of the top ten killers, it is the only disease for which there is no cure or treatment. For most people, there is nothing that they can do to fight back. But one family is doing all they can. The DeMoe family has the most devastating form of the disease that there is: early onset Alzheimer’s, an inherited genetic mutation that causes the disease in one hundred percent of cases, and has a fifty percent chance of being passed onto the next generation. Of the six DeMoe children whose father had it, five have inherited the gene; the sixth, daughter Karla, has inherited responsibility for all of them. But rather than give up in the face of such news, the DeMoes have agreed to spend their precious, abbreviated years as part of a worldwide study that could utterly change the landscape of Alzheimer’s research and offers the brightest hope for future treatments—and possibly a cure. Drawing from several years of in-depth research with this charming and upbeat family, journalist Niki Kapsambelis tells the story of Alzheimer’s through the humanizing lens of these ordinary people made extraordinary by both their terrible circumstances and their bravery. “A compelling narrative…and an educational and emotional chronicle” (Kirkus Reviews, starred review), their tale is intertwined with the dramatic narrative history of the disease, the cutting-edge research that brings us ever closer to a possible cure, and the accounts of the extraordinary doctors spearheading these groundbreaking studies. From the oil fields of North Dakota to the jungles of Colombia, this inspiring race against time redefines courage in the face of this most pervasive and mysterious disease.




Lethal Inheritance


Book Description

On a rescue mission in a mysterious hidden realm, ex-fencing champion Ariel battles treacherous terrain, vicious elementals, and wraith-like demons who feed on fear and want her dead. To defeat the demons and free her mother, she must learn a secret esoteric wisdom to awaken the dormant but potentially explosive power of her mind.Walnut, a quirky old wise man, guides her across stone-strewn plains and wind-swept swamps, past deep ravines and quaint villages, and through a modern city enclosed in a transparent dome. Nick, the powerful Warrior who travels with them, proves a dangerous attraction. His feral energy hits her like a sledgehammer; sometimes it's bliss, but often it's pain. Can Ariel defeat the sadistic demon lord before he kills her and enslaves her mother? The stakes are high, death a real possibility. Fail now, and she fails humanity.




Genetics


Book Description

Genetics accepts contributions that present the results of original research in genetics and related scientific disciplines.







Inheritance, Or, The Vault of Sands


Book Description

Not so very long ago, Eragon - Shadeslayer, Dragon Rider - was nothing more than a poor farm boy, and his dragon, Saphira, only a blue stone in the forest. Now, the fate of an entire civilization rests on their shoulders.







NTA CUET UG 2024 Exam | Biology | 2000+ NCERT Based Topic-wise MCQs | Useful for DU JNU Jamia Milia BHU AMU CHS and All Other Central University


Book Description

The book has been written in response to the lack of quality books in the market on this subject. While there are many books available on this topic, they often lack quality content. Recognizing the challenges faced by students, such as the absence of authentic material, a lack of content based on the exam pattern, and the complexity of subjects, this book includes high-quality content. Main Features of the Book: Based on Latest Exam Pattern & Syllabus Based on the Class 12 NCERT syllabus Designed for students preparing for the (NTA CUET) Common University Entrance Test. 2200+ MCQs with detailed Solutions




Mendelian Inheritance in Man


Book Description

The twelfth edition of this classic reference work includes: - More than 2,000 new entries - A total of more than 9,000 entries - New features and enhancement of the familiar old features - Mapping information on more than 4,000 genes of known function - Information on specific point mutations responsible for more than 700 genetic disorders or neoplasms Mendelian Inheritance in Man (MIM) is a genetic knowledgebase that serves clinical medicine and biomedical research, including the Human Genome Project. It aims to be comprehensive (not only complete, but also collated, integrated, and interpreted), authoritative (not only accurate but also sound in its interpretations and judgements), and timely (not only up-to-date but also historically dimensioned). From a review of the eleventh edition, Reproductive Toxicology: "Even the convenience of computer-based forms of MIM cannot eliminate the need for MIM in book form. The preface provides a wonderful synopsis of human genetics. The information contained in this text serves as a concise review for those with a genetics background." From a review of the tenth edition, New England Journal of Medicine: " Victor McKusick] has been for all these years the shepherd of the development of the field of clinical genetics]. Perhaps his most important pragmatic achievement has been the 10 editions of Mendelian Inheritance in Man, which rapidly became and has remained the principal source of information on inherited diseases for all clinical geneticists. "In addition to the erudite entries in the books, the references given with each description represent a magnificent bibliography of clinical genetics. With McKusick's leadership and continued interest in gene mapping, the book also rep-resents an important compen-dium of the location of genes on specific chromosomes. "The book is a magnificent security blanket for the clinical geneticist and should be in the libraries not only of these specialists, but also of all others who see patients with diseases that have genetic components."




Genetics


Book Description

Genetics: Genes, Genomes, and Evolution unites evolution, genomics, and genetics in a single narrative approach. It is an approach that provides students with a uniquely flexible and contemporary view of genetics, genomics, and evolution.