A Molecule Away from Madness: Tales of the Hijacked Brain


Book Description

Riveting stories of the brain on the brink, from an acclaimed cognitive neurologist. Our brains are the most complex machines known to humankind, but they have an Achilles heel: the very molecules that allow us to exist can also sabotage our minds. Here are gripping accounts of unruly molecules and the diseases that form in their wake. A college student cannot remember if she has eaten breakfast. By dinner, she is strapped to a hospital bed, convinced she is battling zombies. A man planning to propose marriage instead becomes violently enraged, gripped by body spasms so severe that he nearly bites off his own tongue. One after another, poor farmers in South Carolina drop dead from a mysterious epidemic of dementia. With an intoxicating blend of history and intrigue, Sara Manning Peskin invites readers to play medical detective, tracing each diagnosis from the patient to an ailing nervous system. Along the way, Peskin entertains with tales of the sometimes outlandish, often criticized, and forever devoted scientists who discovered it all. Peskin never loses sight of the human impact of these conditions. Alzheimer’s Disease is more than the gradual loss of a loved one; it can be a family’s multigenerational curse. The proteins that abound in every cell of our bodies are not simply strings of oxygen, hydrogen, nitrogen, and carbon; they are the building blocks of our personalities and relationships. A Molecule Away from Madness is an unputdownable journey into the deepest mysteries of our brains.




Fatal Flaws


Book Description

DIVThe story of the revolutionary science that is unraveling the mysteries of mad cow and other fatal brain diseases/div




Wonder Drug


Book Description

A pair of doctors team up to illuminate, through neuroscience and captivating stories from their clinical practice, how serving others—and pitching in to the world in general—is a secret superpower. If a doctor’s prescription could bring you: - Longer life - Better health - More energy and resilience - Less burnout, depression and anxiety - More happiness, fulfillment and well-being - More personal and professional success (including higher income) - And, no harmful side effects Would you take it? In Wonder Drug, physician scientists Stephen Trzeciak, M.D., and Anthony Mazzarelli, M.D., illuminate, through neuroscience and captivating stories from their clinical practices, how being a giving, other-focused person is a secret superpower. Serving others—and pitching in to the world in general—is the evidence-based way to live your life. Kinder people not only live longer, they also live better. Science shows that serving others is not just the right thing to do, it’s also the smart thing to do. Wonder Drug will make you rethink your notions of “self-care” and “me time,” and realize that focusing on others is a potent antidote to the weariness that so many of us feel in modern times. Getting outside of your own head, outside the swirl of self-concern that may dominate your mental chatter, is, ironically, one of the best things you can do for yourself. Building upon their earlier work showing that, in the context of healthcare, having more compassion for patients is a powerful way to not only achieve better patient outcomes, but also promote well-being, resilience and resistance to burnout among healthcare workers, Trzeciak and Mazzarelli now extend their research to uncover how the power of serving others reaches far beyond the medical world and can be a life-changing therapy for everyone. Wonder Drug relates to the varying meanings of giving in real people’s daily lives. The stories in this book will convince and inspire you to make simple prism changes. You don’t need a total life upheaval, just a purposeful shift in mindset. In fact, the crucial first piece of the evidence-based prescription is this: start small. Per science, the best way to well-being and finding your true fulfillment is this: scan your orbit for the people around you in need of help, and go fill that need, as often as you can.




All That Moves Us


Book Description

“The surgical interventions in these pages are dizzying, but the fact that Jay Wellons can write as well as he can operate provides a whole other level of amazement.”—Ann Patchett, #1 New York Times bestselling author of Commonwealth “A powerful and moving account of the intense joys and sorrows of being a pediatric neurosurgeon.”—Henry Marsh, New York Times bestselling author of Do No Harm: Stories of Life, Death, and Brain Surgery ONE OF THE BEST BOOKS OF THE YEAR: The New Yorker, Publishers Weekly Tumors, injuries, ruptured vascular malformations—there is almost no such thing as a non-urgent brain surgery when it comes to kids. For a pediatric neurosurgeon working in the medical minefield of the brain—in which a single millimeter in every direction governs something that makes us essentially human—every day presents the challenge, and the opportunity, to give a new lease on life to a child for whom nothing is yet fully determined and all possibilities still exist. In All That Moves Us, Dr. Jay Wellons pulls back the curtain to reveal the profoundly moving triumphs, haunting complications, and harrowing close calls that characterize the life of a pediatric neurosurgeon, bringing the high-stakes drama of the operating room to life with astonishing candor and honest compassion. Reflecting on lessons learned over twenty-five years and thousands of operations completed on some of the most vulnerable and precious among us, Wellons recounts in gripping detail the moments that have shaped him as a doctor, as a parent, and as the only hope for countless patients whose young lives are in his hands. Wellons shares scenes of his early days as the son of a military pilot, the years of grueling surgical training, and true stories of what it’s like to treat the brave children he meets on the threshold between life and death. From the little boy who arrived at the hospital near death from a gunshot wound to the head, to the eight-year-old whose shredded nerves were repaired using suture as fine as human hair, to the brave mother-to-be undergoing fetal spinal cord surgery, All That Moves Us is an unforgettable portrait of the countless human dramas that take place in a busy modern children’s hospital—and a meditation on the marvel of life as seen from under the white-hot lights of the operating room.




The Nocturnal Brain


Book Description

A renowned neurologist shares the true stories of people unable to get a good night’s rest in The Nocturnal Brain: Nightmares, Neuroscience, and the Secret World of Sleep, a fascinating exploration of the symptoms and syndromes behind sleep disorders. For Dr. Guy Leschziner’s patients, there is no rest for the weary in mind and body. Insomnia, narcolepsy, night terrors, apnea, and sleepwalking are just a sampling of conditions afflicting sufferers who cannot sleep—and their experiences in trying are the stuff of nightmares. Demoniac hallucinations frighten people into paralysis. Restless legs rock both the sleepless and their sleeping partners with unpredictable and uncontrollable kicking. Out-of-sync circadian rhythms confuse the natural body clock’s days and nights. Then there are the extreme cases. A woman in a state of deep sleep who gets dressed, unlocks her car, and drives for several miles before returning to bed. The man who has spent decades cleaning out kitchens while “sleep-eating.” The teenager prone to the serious, yet unfortunately nicknamed Sleeping Beauty Syndrome stuck in a cycle of excessive unconsciousness, binge eating, and uncharacteristic displays of aggression and hypersexuality while awake. With compassionate stories of his patients and their conditions, Dr. Leschziner illustrates the neuroscience behind our sleeping minds, revealing the many biological and psychological factors necessary in getting the rest that will not only maintain our physical and mental health, but improve our cognitive abilities and overall happiness.




The Man Who Tasted Words


Book Description

In The Man Who Tasted Words, Guy Leschziner leads readers through the senses and how, through them, our brain understands or misunderstands the world around us. Vision, hearing, taste, smell, and touch are what we rely on to perceive the reality of our world. Our senses are the conduits that bring us the scent of a freshly brewed cup of coffee or the notes of a favorite song suddenly playing on the radio. But are they really that reliable? The Man Who Tasted Words shows that what we perceive to be absolute truths of the world around us is actually a complex internal reconstruction by our minds and nervous systems. The translation into experiences with conscious meaning—the pattern of light and dark on the retina that is transformed into the face of a loved one, for instance—is a process that is invisible, undetected by ourselves and, in most cases, completely out of our control. In The Man Who Tasted Words, neurologist Guy Leschziner explores how our nervous systems define our worlds and how we can, in fact, be victims of falsehoods perpetrated by our own brains. In his moving and lyrical chronicles of lives turned upside down by a disruption in one or more of their five senses, he introduces readers to extraordinary individuals, like one man who actually “tasted” words, and shows us how sensory disruptions like that have played havoc, not only with their view of the world, but with their relationships as well. The cases Leschziner shares in The Man Who Tasted Words are extreme, but they are also human, and teach us how our lives and what we perceive as reality are both ultimately defined by the complexities of our nervous systems.




The Facemaker


Book Description

A New York Times Bestseller Finalist for the 2022 Kirkus Prize | Named a best book of the year by The Guardian "Enthralling. Harrowing. Heartbreaking. And utterly redemptive. Lindsey Fitzharris hit this one out of the park." —Erik Larson, author of The Splendid and the Vile Lindsey Fitzharris, the award-winning author of The Butchering Art, presents the compelling, true story of a visionary surgeon who rebuilt the faces of the First World War’s injured heroes, and in the process ushered in the modern era of plastic surgery. From the moment the first machine gun rang out over the Western Front, one thing was clear: humankind’s military technology had wildly surpassed its medical capabilities. Bodies were battered, gouged, hacked, and gassed. The First World War claimed millions of lives and left millions more wounded and disfigured. In the midst of this brutality, however, there were also those who strove to alleviate suffering. The Facemaker tells the extraordinary story of such an individual: the pioneering plastic surgeon Harold Gillies, who dedicated himself to reconstructing the burned and broken faces of the injured soldiers under his care. Gillies, a Cambridge-educated New Zealander, became interested in the nascent field of plastic surgery after encountering the human wreckage on the front. Returning to Britain, he established one of the world’s first hospitals dedicated entirely to facial reconstruction. There, Gillies assembled a unique group of practitioners whose task was to rebuild what had been torn apart, to re-create what had been destroyed. At a time when losing a limb made a soldier a hero, but losing a face made him a monster to a society largely intolerant of disfigurement, Gillies restored not just the faces of the wounded but also their spirits. The Facemaker places Gillies’s ingenious surgical innovations alongside the dramatic stories of soldiers whose lives were wrecked and repaired. The result is a vivid account of how medicine can be an art, and of what courage and imagination can accomplish in the presence of relentless horror.




The Disappearing Spoon


Book Description

From New York Times bestselling author Sam Kean comes incredible stories of science, history, finance, mythology, the arts, medicine, and more, as told by the Periodic Table. Why did Gandhi hate iodine (I, 53)? How did radium (Ra, 88) nearly ruin Marie Curie's reputation? And why is gallium (Ga, 31) the go-to element for laboratory pranksters? The Periodic Table is a crowning scientific achievement, but it's also a treasure trove of adventure, betrayal, and obsession. These fascinating tales follow every element on the table as they play out their parts in human history, and in the lives of the (frequently) mad scientists who discovered them. The Disappearing Spoon masterfully fuses science with the classic lore of invention, investigation, and discovery -- from the Big Bang through the end of time. Though solid at room temperature, gallium is a moldable metal that melts at 84 degrees Fahrenheit. A classic science prank is to mold gallium spoons, serve them with tea, and watch guests recoil as their utensils disappear.




The Duchess Countess


Book Description

'A scintillating story superbly told... [Ostler] packs every paragraph with eye-opening detail' The Times 'A rollicking read... [Ostler] tells Elizabeth's story with admirable style and gusto' Sunday Times 'Terrifically entertaining: if you liked Bridgerton, you’ll love this...and her research is impeccable' Evening Standard 'Fascinating. Magnificent.​ Sensitively told' Hallie Rubenhold, author of The Five 'Catherine Ostler’s superb, gripping, decadent biography brings an extraordinary woman and a whole world blazingly to life' Simon Sebag Montefiore When the glamorous Elizabeth Chudleigh, Duchess of Kingston, Countess of Bristol, went on trial at Westminster Hall for bigamy in April 1776, the story drew more attention in society than the American War of Independence. A clandestine, candlelit wedding to the young heir to an earldom, a second marriage to a Duke, a lust for diamonds and an electrifying appearance at a masquerade ball in a diaphanous dress: no wonder the trial was a sensation. However, Elizabeth refused to submit to public humiliation and retire quietly. Rather than backing gracefully out of the limelight, she embarked on a Grand Tour of Europe, being welcomed by the Pope and Catherine the Great among others. As maid of honour to Augusta, Princess of Wales, Elizabeth led her life in the inner circle of the Hanoverian court and her exploits delighted and scandalised the press and the people. She made headlines, and was a constant feature in penny prints and gossip columns. Writers were intrigued by her. Thackeray drew on Elizabeth as inspiration for his calculating, alluring Becky Sharp. But her behaviour, often depicted as attention-seeking and manipulative, hid a more complex tale – that of Elizabeth’s fight to overcome personal tragedy and loss. Now, in this brilliantly told and evocative biography, Catherine Ostler takes a fresh look at Elizabeth’s story and seeks to understand and reappraise a woman who refused to be defined by society’s expectations of her. A woman who was by turns, brave, loving and generous but also reckless, greedy and insecure; a woman totally unwilling to accept the female status of underdog or to hand over all the power, the glory and the adventures of life to men.




Mind on Fire


Book Description

Shortlisted for the Wellcome Book Prize 2019 '[A] painfully intense, courageous and gripping account of [Fanning's] journey to the underworld of madness and back. This is a brave and instructive book.' Irish Times 'Extraordinary. An account of mental illness, grief, delusions, homelessness, a fractured family relationship ... and all while trying to recover and create. Superb writing on a frequently difficult subject.' Sinéad Gleeson Arnold Thomas Fanning had his first experience of depression during adolescence, following the death of his mother. Some ten years later, an up-and-coming playwright, he was overcome by mania and delusions. Thus began a terrible period in which he was often suicidal, increasingly disconnected from family and friends, sometimes in trouble with the law, and homeless in London. Drawing on his own memories, the recollections of people who knew him when he was at his worst, and medical and police records, Arnold Thomas Fanning has produced a beautifully written, devastatingly intense account of madness - and recovery, to the point where he has not had any serious illness for over a decade and has become an acclaimed playwright. Fanning conveys the consciousness of a person living with mania, psychosis and severe depression with a startling precision and intimacy. Mind on Fire is the gripping, sometimes harrowing, and ultimately uplifting testament of a person who has visited hellish regions of the mind. 'Arnold Thomas Fanning offers the most vivid and unflinching window into the mind of someone who is in the throes of madness ... It was like nothing I'd read before' Rick Edwards 'Mind on Fire is a truly powerful, arresting, haunting account. Arnold Thomas Fanning has reckoned with the darkest matter of his heart and mind, and I challenge anyone not to be moved by that.' Sara Baume, author of Spill Simmer Falter Wither and A Line Made by Walking 'In this strange and singular book, Arnold Thomas Fanning mercilessly excavates the infernal underworld of his own years of madness. As reminiscent as it occasionally is of John Healy's The Grass Arena, and even of Orwell's Down and Out in Paris and London, the book is ultimately not quite like anything else I've read, and brought me as close to the lived reality of mental illness as I have ever been. It's a significant achievement: a painful, inexorable work of autobiography, whose existence is its own form of redemption.' Mark O'Connell, Baillie Gifford Prize-shortlisted author of To Be a Machine 'This is an extraordinary memoir about how it feels to be depressed, delusional, desperate' The Observer 'Incredibly important' Emilie Pine, author of Notes to Self 'A ratcheting pace, a tight first-person immediacy, and utterly staggering to be a passenger over its entire warped course ... An indelible, ground-shaking account' Hilary A White, Irish Independent, Memoir of the Year, Best Reads of 2018 'A spellbinding memoir that should prove both moving and hopefully cathartic for the reader.' RTE Culture 'Told in tight and immediate first-person, and imbued with a startling momentum that ratchets unnervingly, Fanning's publishing debut ... is a significant achievement and should be a talking point in publishing this year.' Irish Independent 'Fanning's debut book lays it on the line in a deeply personal and compelling chronicle of his descent into depression and his way back out.' RTE Guide 'Wonderful' Joseph O'Connor, Irish Times Books of the Year 'Unsparingly direct, searing and honest ... It is gripping to read and must have been exhausting to live' Medical Independent 'One of the most gripping and revealing memoirs I've read in a long time. A controlled and artful exploration of absolute loss of control, an unsettling and at times very moving reconstruction of a period of serious mental illness, Mind on Fire is a beautiful book about a terrifying thing.' Mark O'Connell, Irish Times Books of the Year 'Gripping' Sinéad Gleeson, Irish Times Books of the Year 'Shocking' Liz Nugent, Irish Times Books of the Year 'Poignant, beautifully detailed memoir' Sarah Gilmartin, Irish Times, Best debuts of 2018 'Brave and illuminating' Sunday Business Post 'This is the type of account that not only grips you wholesale as the pages flitter past, it also changes your very perception of psychology' Hilary A White, Sunday Independent Memoir of the Year