A New Biology for the 21st Century


Book Description

Now more than ever, biology has the potential to contribute practical solutions to many of the major challenges confronting the United States and the world. A New Biology for the 21st Century recommends that a "New Biology" approach-one that depends on greater integration within biology, and closer collaboration with physical, computational, and earth scientists, mathematicians and engineers-be used to find solutions to four key societal needs: sustainable food production, ecosystem restoration, optimized biofuel production, and improvement in human health. The approach calls for a coordinated effort to leverage resources across the federal, private, and academic sectors to help meet challenges and improve the return on life science research in general.




Biobanking in the 21st Century


Book Description

Biobanking, an emerging field supported by academia, industry and health administrators alike, is distinctly different today from the practice that once defined it. The science of Biobanking, which initially involved simply storing blood or tissue samples in a freezer, is now a highly sophisticated field of research, and expected to grow exponentially over the next decade or two. This book aims to serve the purpose of further enriching the available literature on Biobanking, by offering unique and more useful collection of ideas for the future. The book outlines the experiences of developing modern Biobanking repositories in different countries, whilst covering specific topics regarding the many aspects of Biobanking. This book will be of interest to a wide range of readers including: academics, students, volunteers and advocates of patients’ rights.




Implementing the New Biology


Book Description

As the second decade of the 21st century begins, the challenge of how to feed a growing world population and provide sustainable, affordable energy to fulfill daily needs, while also improving human health and protecting the environment, is clear and urgent. Increasing demand for food and energy is projected at the same time as the supply of land and other resources decrease. Increasing levels of greenhouse gasses alter climate, which, in turn, has life-changing implications for a broad range of plant and animal species. But promising developments are on the horizon-scientific discoveries and technologies that have the potential to contribute practical solutions to these seemingly intractable problems. As described in the 2009 National Research Council book, A New Biology for the 21st Century, biological research has experienced extraordinary scientific and technological advances in recent years that have allowed biologists to collect and make sense of ever more detailed observations at ever smaller time intervals. With these advances have come increasingly fruitful collaborations of biologists with scientists and engineers from other disciplines. A New Biology for the 21st Century called for a series of workshops to provide concrete examples of what New Biology research programs could look like. The present volume summarizes the first of those workshops, Implementing the New Biology: Decadal Challenges Linking Food, Energy, and the Environment.




Emerging Threats of Synthetic Biology and Biotechnology


Book Description

Synthetic biology is a field of biotechnology that is rapidly growing in various applications, such as in medicine, environmental sustainability, and energy production. However these technologies also have unforeseen risks and applications to humans and the environment. This open access book presents discussions on risks and mitigation strategies for these technologies including biosecurity, or the potential of synthetic biology technologies and processes to be deliberately misused for nefarious purposes. The book presents strategies to prevent, mitigate, and recover from 'dual-use concern' biosecurity challenges that may be raised by individuals, rogue states, or non-state actors. Several key topics are explored including opportunities to develop more coherent and scalable approaches to govern biosecurity from a laboratory perspective up to the international scale and strategies to prevent potential health and environmental hazards posed by deliberate misuse of synthetic biology without stifling innovation. The book brings together the expertise of top scholars in synthetic biology and biotechnology risk assessment, management, and communication to discuss potential biosecurity governing strategies and offer perspectives for collaboration in oversight and future regulatory guidance.




Practising Interdisciplinarity


Book Description

This book examines the epistemological, social and political dimensions of practising interdisciplinary approaches to enhance knowledge, pedagogy, and methodological aspects of research in the South Asian context. The volume sets the context by bringing together a range of ideas, questions and reflections on the concept of interdisciplinarity, the numerous waves of interdisciplinarity in contemporary history of knowledge, which were radically different from each other in their epistemological and political orientations. The book revisits the concept of interdisciplinarity and takes into cognizance the importance of the mutual shaping of knowledge and politics in our search for inclusive and sustainable future(s). The book offers a blend of both conceptual and institutional discourses on interdisciplinarity and the personal experiences of leading practitioners, bringing together critical engagements from different vantage points on practising it. It will be of interest to researchers, scholars and practitioners of social sciences and humanities disciplines as well as interdisciplinary fields such as educational studies, development studies, women’s studies, media studies, cultural studies, urban studies, labour studies, legal studies, public health, disability studies, global/international studies and performing arts. It will also be useful for policy planners, development practitioners, activists and social organizers working in related fields.




Mathematical Concepts and Methods in Modern Biology


Book Description

Mathematical Concepts and Methods in Modern Biology offers a quantitative framework for analyzing, predicting, and modulating the behavior of complex biological systems. The book presents important mathematical concepts, methods and tools in the context of essential questions raised in modern biology.Designed around the principles of project-based learning and problem-solving, the book considers biological topics such as neuronal networks, plant population growth, metabolic pathways, and phylogenetic tree reconstruction. The mathematical modeling tools brought to bear on these topics include Boolean and ordinary differential equations, projection matrices, agent-based modeling and several algebraic approaches. Heavy computation in some of the examples is eased by the use of freely available open-source software. - Features self-contained chapters with real biological research examples using freely available computational tools - Spans several mathematical techniques at basic to advanced levels - Offers broad perspective on the uses of algebraic geometry/polynomial algebra in molecular systems biology




Organized Innovation


Book Description

"Organized" and "innovation" are words rarely heard together. But an organized approach to innovation is precisely what America needs today. This book presents a blueprint for coordinating technology breakthroughs to advance America's global competitiveness and prosperity. That prosperity is at risk. As other nations bolster technology innovation efforts, America's research, development, and commercialization enterprise is falling behind. An "innovation gap" has emerged in recent decades, where US universities focus on basic research and industry concentrates on incremental product development. The country has failed to address the innovation gap because of three myths--innovation is about lone geniuses, the free market, and serendipity. These myths blind us from recognizing our dysfunctional system of unorganized innovation. In Organized Innovation, Currall, Frauenheim, Perry and Hunter provide a framework for optimizing the way America creates, develops, and commercializes technology breakthroughs. A roadmap for universities, business, and government, the book is grounded in the authors' seminal study of the National Science Foundation's Engineering Research Center program, which has returned to the US economy more than ten times the funding invested in it. For too long, our approach to technology innovation has been unorganized. The authors enable us to turn the page. They show us how to organize innovation for a more prosperous, hopeful future.




The Role of Theory in Advancing 21st-Century Biology


Book Description

Although its importance is not always recognized, theory is an integral part of all biological research. Biologists' theoretical and conceptual frameworks inform every step of their research, affecting what experiments they do, what techniques and technologies they develop and use, and how they interpret their data. By examining how theory can help biologists answer questions like "What are the engineering principles of life?" or "How do cells really work?" the report shows how theory synthesizes biological knowledge from the molecular level to the level of whole ecosystems. The book concludes that theory is already an inextricable thread running throughout the practice of biology; but that explicitly giving theory equal status with other components of biological research could help catalyze transformative research that will lead to creative, dynamic, and innovative advances in our understanding of life.




Can Science Make Sense of Life?


Book Description

Since the discovery of the structure of DNA and the birth of the genetic age, a powerful vocabulary has emerged to express science’s growing command over the matter of life. Armed with knowledge of the code that governs all living things, biology and biotechnology are poised to edit, even rewrite, the texts of life to correct nature’s mistakes. Yet, how far should the capacity to manipulate what life is at the molecular level authorize science to define what life is for? This book looks at flash points in law, politics, ethics, and culture to argue that science’s promises of perfectibility have gone too far. Science may have editorial control over the material elements of life, but it does not supersede the languages of sense-making that have helped define human values across millennia: the meanings of autonomy, integrity, and privacy; the bonds of kinship, family, and society; and the place of humans in nature.




Positioning Synthetic Biology to Meet the Challenges of the 21st Century


Book Description

Synthetic biology-unlike any research discipline that precedes it-has the potential to bypass the less predictable process of evolution to usher in a new and dynamic way of working with living systems. Ultimately, synthetic biologists hope to design and build engineered biological systems with capabilities that do not exist in natural systems-capabilities that may ultimately be used for applications in manufacturing, food production, and global health. Importantly, synthetic biology represents an area of science and engineering that raises technical, ethical, regulatory, security, biosafety, intellectual property, and other issues that will be resolved differently in different parts of the world. As a better understanding of the global synthetic biology landscape could lead to tremendous benefits, six academies-the United Kingdom's Royal Society and Royal Academy of Engineering, the United States' National Academy of Sciences and National Academy of Engineering, and the Chinese Academy of Science and Chinese Academy of Engineering-organized a series of international symposia on the scientific, technical, and policy issues associated with synthetic biology. Positioning Synthetic Biology to Meet the Challenges of the 21st Century summarizes the symposia proceedings.