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A Review of the Draft Report of the NCI-CDC Working Group to Revise the 1985 Radioepidemiological Tables

Author : National Academy of Sciences

Publisher : National Academies Press

Page : 63 pages

File Size : 16,73 MB

Release : 2001-01-22

Category : Science

ISBN : 0309072506

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Book Description

The National Research Council was asked by the Centers for Disease Control and Prevention (CDC) to review the draft report of the National Cancer Institute (NCI)-CDC's working group charged with revising the 1985 radioepidemiological tables. To this end, a subcommittee was formed consisting of members of the Council's Committee on an Assessment of the Centers for Disease Control and Prevention Radiation Programs and other experts. The original tables were mandated under Public Law 97-414 (the "Orphan Drug Act") and were intended to provide a means of estimating the probability that a person who developed any of a series of radiation-related cancers, developed the cancer as a result of a specific radiation dose received before the onset of the cancer. The mandate included a provision for periodic updating of the tables. The motivation for the current revision reflects the availability of new data, especially on cancer incidence, and new methods of analysis, and the need for a more thorough treatment of uncertainty in the estimates than was attempted in the original tables.



Improving the Presumptive Disability Decision-Making Process for Veterans

Author : Institute of Medicine

Publisher : National Academies Press

Page : 813 pages

File Size : 13,90 MB

Release : 2008-05-15

Category : Medical

ISBN : 0309164397

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Book Description

The United States has long recognized and honored the service and sacrifices of its military and veterans. Veterans who have been injured by their service (whether their injury appears during service or afterwards) are owed appropriate health care and disability compensation. For some medical conditions that develop after military service, the scientific information needed to connect the health conditions to the circumstances of service may be incomplete. When information is incomplete, Congress or the Department of Veterans Affairs (VA) may need to make a "presumption" of service connection so that a group of veterans can be appropriately compensated. The missing information may be about the specific exposures of the veterans, or there may be incomplete scientific evidence as to whether an exposure during service causes the health condition of concern. For example, when the exposures of military personnel in Vietnam to Agent Orange could not be clearly documented, a presumption was established that all those who set foot on Vietnam soil were exposed to Agent Orange. The Institute of Medicine (IOM) Committee was charged with reviewing and describing how presumptions have been made in the past and, if needed, to make recommendations for an improved scientific framework that could be used in the future for determining if a presumption should be made. The Committee was asked to consider and describe the processes of all participants in the current presumptive disability decision-making process for veterans. The Committee was not asked to offer an opinion about past presumptive decisions or to suggest specific future presumptions. The Committee heard from a range of groups that figure into this decision-making process, including past and present staffers from Congress, the VA, the IOM, veterans service organizations, and individual veterans. The Department of Defense (DoD) briefed the Committee about its current activities and plans to better track the exposures and health conditions of military personnel. The Committee further documented the current process by developing case studies around exposures and health conditions for which presumptions had been made. Improving the Presumptive Disability Decision-Making Process for Veterans explains recommendations made by the committee general methods by which scientists, as well as government and other organizations, evaluate scientific evidence in order to determine if a specific exposure causes a health condition.



A Review of the Dose Reconstruction Program of the Defense Threat Reduction Agency

Author : National Research Council

Publisher : National Academies Press

Page : 415 pages

File Size : 11,1 MB

Release : 2003-08-21

Category : Nature

ISBN : 0309168023

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Book Description

From 1945 through 1962, the US atmospheric nuclear weapons testing program involved hundreds of thousands of military and civilian personnel, and some of them were exposed to ionizing radiation. Veterans' groups have since been concerned that their members' health was affected by radiation exposure associated with participation in nuclear tests and have pressured Congress for disability compensation. Several pieces of legislation have been passed to compensate both military and civilian personnel for such health effects. Veterans' concerns about the accuracy of reconstructed doses prompted Congress to have the General Accounting Office (GAO) review the dose reconstruction program used to estimate exposure. The GAO study concluded that dose reconstruction is a valid method of estimating radiation dose and could be used as the basis of compensation. It also recommended an independent review of the dose reconstruction program. The result of that recommendation was a congressional mandate that the Defense Threat Reduction Agency (DTRA), a part of the Department of Defense, ask the National Research Council to conduct an independent review of the dose reconstruction program. In response to that request, the National Research Council established the Committee to Review the Dose Reconstruction Program of the Defense Threat Reduction Agency in the Board on Radiation Effects Research (BRER). The committee randomly selected sample records of doses that had been reconstructed by DTRA and carefully evaluated them. The committee's report describes its findings and provides responses to many of the questions that have been raised by the veterans.



Statistical Methods in Environmental Epidemiology

Author : Duncan C. Thomas

Publisher : OUP Oxford

Page : 448 pages

File Size : 40,31 MB

Release : 2009-02-26

Category : Science

ISBN : 0191552690

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Book Description

Environmental epidemiology is the study of the environmental causes of disease in populations and how these risks vary in relation to intensity and duration of exposure and other factors like genetic susceptibility. As such, it is the basic science upon which governmental safety standards and compensation policies for environmental and occupational exposure are based. Profusely illustrated with examples from the epidemiologic literature on ionizing radiation and air pollution, this text provides a systematic treatment of the statistical challenges that arise in environmental health studies and the use epidemiologic data in formulating public policy, at a level suitable for graduate students and epidemiologic researchers. After a general overview of study design and statistical methods for epidemiology generally, the book goes on to address the problems that are unique to environmental health studies, special-purpose designs like two-phase case-control studies and countermatching, statistical methods for modeling exposure-time-response relationships, longitudinal and time-series studies, spatial and ecologic methods, exposure measurement error, interactions, and mechanistic models. It also discusses studies aimed at evaluating the public health benefits of interventions to improve the environment, the use of epidemiologic data to establish environmental safety standards and compensation policy, and concludes with emerging problems in reproductive epidemiology, natural and man-made disasters like global warming, and the global burden of environmentally caused disease. No other book provides such a broad perspective on the methodological challenges in this field at a level accessible to both epidemiologists and statisticians.



Assessment of the Scientific Information for the Radiation Exposure Screening and Education Program

Author : National Research Council

Publisher : National Academies Press

Page : 431 pages

File Size : 30,30 MB

Release : 2005-10-01

Category : Science

ISBN : 0309096103

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Book Description

The Radiation Exposure Compensation Act (RECA) was set up by Congress in 1990 to compensate people who have been diagnosed with specified cancers and chronic diseases that could have resulted from exposure to nuclear-weapons tests at various U.S. test sites. Eligible claimants include civilian onsite participants, downwinders who lived in areas currently designated by RECA, and uranium workers and ore transporters who meet specified residence or exposure criteria. The Health Resources and Services Administration (HRSA), which oversees the screening, education, and referral services program for RECA populations, asked the National Academies to review its program and assess whether new scientific information could be used to improve its program and determine if additional populations or geographic areas should be covered under RECA. The report recommends Congress should establish a new science-based process using a method called "probability of causation/assigned share" (PC/AS) to determine eligibility for compensation. Because fallout may have been higher for people outside RECA-designated areas, the new PC/AS process should apply to all residents of the continental US, Alaska, Hawaii, and overseas US territories who have been diagnosed with specific RECA-compensable diseases and who may have been exposed, even in utero, to radiation from U.S. nuclear-weapons testing fallout. However, because the risks of radiation-induced disease are generally low at the exposure levels of concern in RECA populations, in most cases it is unlikely that exposure to radioactive fallout was a substantial contributing cause of cancer.



Health Risks from Exposure to Low Levels of Ionizing Radiation

Author : Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation

Publisher : National Academies Press

Page : 422 pages

File Size : 48,75 MB

Release : 2006-03-23

Category : Science

ISBN : 0309133343

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Book Description

This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called “late” effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation.



Code of Federal Regulations

Author :

Publisher :

Page : 1064 pages

File Size : 18,8 MB

Release : 2016

Category : Administrative law

ISBN :

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Book Description

Special edition of the Federal Register, containing a codification of documents of general applicability and future effect ... with ancillaries.



The Impact of Low-Level Radioactive Waste Management Policy on Biomedical Research in the United States

Author : National Research Council

Publisher : National Academies Press

Page : 66 pages

File Size : 35,61 MB

Release : 2001-03-09

Category : Political Science

ISBN : 0309073316

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Book Description

The National Research Council's Committee on the Impact of Low-Level Radioactive Waste Management Policy on Biomedical Research in the United States was called on to assess the effects of the low-level radioactive waste management policy on the current and future activities of biomedical research. This report provides an assessment of the effects of the current management policy for low-level radioactive waste (LLRW), and resulting consequences, such as higher LLRW disposal costs and onsite storage of LLRW, on the current and future activities of biomedical research. That assessment will include evaluating the effects that the lack of facilities and disposal capacity, and rules of disposal facilities, have on institutions conducting medical and biological research and on hospitals where radioisotopes are used for the diagnosis and treatment of disease.



A Risk Reduction Strategy for Human Exploration of Space

Author : National Research Council

Publisher : National Academies Press

Page : 162 pages

File Size : 30,88 MB

Release : 2006-03-16

Category : Science

ISBN : 0309180341

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Book Description

Extending the spatial and temporal boundaries of human space flight is an important goal for the nation and for the National Aeronautics and Space Administration (NASA). However, human space flight remains an endeavor with substantial risks, and these risks must be identified, managed, and mitigated appropriately to achieve the nation's goals in space. The Bioastronautics Roadmap (BR) is the result of extensive, commendable efforts on the part of NASA to prioritize research efforts to meet these challenges. In 2003, NASA asked the Institute of Medicine (IOM), in collaboration with the Division on Engineering and Physical Sciences of the National Academies, to conduct a review of the BR. Specifically, NASA asked the committee to (1) conduct a comprehensive assessment and report of the strengths and weaknesses of the content and processes of the Bioastronautics Roadmap as applied to the missions described in the President's exploration initiative and (2) identify the unique challenges for accomplishing its goals and objectives. In September 2004, the committee released its preliminary report to NASA entitled Preliminary Considerations Regarding NASA's Bioastronautics Critical Path Roadmap. That document presented the committee's preliminary conclusions about the strengths and weaknesses of the April 2004 version of the BR. This report, A Risk Reductions Strategy for Human Exploration of Space, builds on those preliminary conclusions and provides recommendations to NASA about how to address the issues identified by the committee.



Cancer Epidemiology and Prevention

Author : David Schottenfeld

Publisher : Oxford University Press

Page : 1411 pages

File Size : 35,42 MB

Release : 2006-08-24

Category : Medical

ISBN : 0195149610

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Book Description

Drawing widely from international sources, the new edition of this reference book on cancer causes, incidence, mortality and survival patterns, also includes chapters on social class, obesity, physical activity and chemoprevention plus other related topics in the field.