Author : Harinder Gill
Publisher : Frontiers Media SA
Page : 77 pages
File Size : 33,56 MB
Release : 2022-02-22
Category : Medical
ISBN : 2889744752
Author : Oussama Abla
Publisher : Springer
Page : 275 pages
File Size : 31,4 MB
Release : 2018-04-25
Category : Medical
ISBN : 331964257X
This book provides a comprehensive overview on the clinical issues and biology of acute promyelocytic leukemia (APL) and on the molecular mechanisms of targeted therapy with ATRA and ATO. The text covers major topics such as the pathophysiology of APL coagulopathy, biologic and clinical differences between children and adults with APL, and the role of minimal residual disease monitoring. Additionally, the book summarizes historical, current, and future treatment strategies in both adults and children, while highlighting the most recent therapeutic recommendations for relapsed disease and the evolving indications for autologous and allogeneic stem cell transplant. This volume also features chapters focusing on secondary APL and therapy, late effects, rare presentations such as APL in the elderly and during pregnancy, and rare APL variants that may represent therapeutic challenges. Written by top experts in the field, Acute Promyelocytic Leukemia: A Clinical Guide is a valuable resource for clinicians and researchers who treat and investigate this disease in children and adults.
Author : Takanori Ueda
Publisher : Springer
Page : 354 pages
File Size : 23,42 MB
Release : 2017-04-17
Category : Medical
ISBN : 9811033323
This book focuses on the latest progress in chemotherapy for leukemia and related diseases, including still-ongoing but promising studies. The effectiveness of treatment for chronic myeloid leukemia and acute promyelocytic leukemia has been dramatically improved in recent years. This improvement has been made possible with the development of molecular targeted agents such as bcr-abl tyrosine kinase inhibitors and all-trans retinoic acid. The antibody for the unique target of chemokine receptor 4 for adult T-cell leukemia/lymphoma, or FLT3 inhibitors (signaling inhibitors) has been applied to other leukemias. Also, chemotherapeutic agents including antimetabolite analogues such as clofarabine, and azacitidine (an epigenetic regulator) have undergone progressive development. Meanwhile, the novel concept of therapy targeting leukemic stem cells has been developed. The contributors discuss prospective results of basic and preclinical studies and clinical possibilities based on the effects for leukemic stem cells. This work facilitates a comprehensive understanding of modern treatment methodology for leukemia. The volume therefore will greatly benefit not only hematologists but also oncologists, all physicians who specialize in blood cancer, and pharmacologists who are involved in the development of therapeutic agents for leukemia.
Author :
Publisher :
Page : pages
File Size : 42,93 MB
Release : 2017
Category :
ISBN :
Successful treatment with arsenic trioxide and retinoic acid for acute promyelocytic leukemia in a very elderly patient Boulet E 1, Bailly B1. Delrieu V1, Detry G2, Kentos A1, Ngirabacu M.-C1, Ravoet C1, Bettens S3, Van Obbergh F1, Sid S1. Department of Hematology1, Clinical Biology2 and Geriatric3, Jolimont, 7100 La Louviu00e8re Objectives: Chemotherapy free treatment with all-transretinoic-acid (ATRA) and arsenic trioxide (ATO) for promyelocytic acute leukemia (APL) has considerably improved the prognosis of APL, especially in frailer patients who wouldnu2019t be eligible for conventional chemotherapy. Methods: It seemed relevant to report the case of a 90-yearold patient successfully treated with a chemotherapy-free therapy following the 2013 protocol of Lo-Coco1 (ATO 0,15mg/kg/d and ATRA 45mg/m2/d until complete remission). Results: After comprehensive geriatric assessment was checked, treatment was started. The ATO dose was reduced by 50% (0.075 mg/kg) given the chronic kidney disease and ATRA was given at a conventional dose of 45 mg/m2. There were minor complications during induction like grade 1 differentiation syndrome, febrile neutropenia and QTc prolongation. Full blood count normalized on the 26th day, and the marrow aspirate performed showed morphological and cytogenetic remission and a decrease of PMLRARu03b1 by RT-PCR at 5,6% from baseline. She received 3 cycles of consolidation. The patient did not present any complication during consolidation treatment. At the end of the treatment, the PML-RARu03b1 fusion transcript was undetectable on peripheral blood. Conclusion: Treatment with ATRA and ATO was feasible, safe and led to a complete remission even in our very elderly patient diagnosed with acute promyelocytic leukemia. Comprehensive geriatric assessment should always be performed before initiation of the treatment.
Author : Ajay Vora
Publisher : Springer
Page : 345 pages
File Size : 28,65 MB
Release : 2017-04-21
Category : Medical
ISBN : 3319397087
This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.
Author : Hillard M. Lazarus
Publisher : Springer Science & Business Media
Page : 885 pages
File Size : 20,93 MB
Release : 2010-03-02
Category : Medical
ISBN : 1597454788
Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.
Author : Nicolaus Kröger
Publisher :
Page : 688 pages
File Size : 13,64 MB
Release : 2020-10-08
Category : Medical
ISBN : 9781013273674
This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.
Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
Page : 2004 pages
File Size : 16,76 MB
Release : 2017-03-10
Category : Medical
ISBN : 111900084X
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author : Vinod Pullarkat
Publisher : Springer Nature
Page : 200 pages
File Size : 41,43 MB
Release : 2021-10-09
Category : Medical
ISBN : 3030783111
This book provides a concise update on current understanding of the biology of acute and chronic leukemias and other bone marrow neoplasms, including myelodysplastic and myeloproliferative disorders, and explores new and emerging treatments. There is a particular focus on the molecular abnormalities that are drivers of leukemia and on their detection by modern molecular techniques. Knowledge of the ways in which genomic and metabolic abnormalities in the hematologic neoplasms affect prognosis and treatment decision making is reviewed. Detailed attention is devoted to targeted therapies, including novel drugs, and to potential targets for future drug development. In addition, readers find in-depth discussion of cellular and antibody-based immunotherapies as well as the role of hematopoietic stem cell transplantation in the treatment of leukemias and bone marrow malignancies. The book is of special interest for hematologists, oncologists, and cancer researchers; it is also of value for hematology trainees and medical students.
Author : Rolf-Dieter Wegner
Publisher : Springer Science & Business Media
Page : 464 pages
File Size : 38,45 MB
Release : 2013-11-11
Category : Medical
ISBN : 3642599184
Following a section on tissue culture, chromosome staining and basic information about karyotyping, this text presents nomenclature and quality standards, as well as protocols of relevance to comprehensive cytogenetic diagnostics.
