The Human Endometrium


Book Description

The structural, biochemical and clinical events related to menstruation, implantation, parturition, endometriosis, abnormal uterine bleeding and endometrial cancer are discussed in this comprehensive volume on the biological functions of the endometrium. New topics, such as the biochemical and molecular mechanisms regulating maternal embryonic interaction, are explored, and gynecologic endoscopy and therapeutic tools are discussed. The proceedings of the first conference is also available from the Academy, as volume 622 of The Annals of The New York Academy of Science.




Epicardial Adipose Tissue


Book Description

This book is the first authoritative and comprehensive volume dedicated to epicardial adipose tissue (EAT). It provides an up-to-date and highly illustrated synopsis of the anatomical, biomolecular, genetic, imaging features, and clinical applications of EAT and its role in cardiovascular disease. It relays to the reader a contemporary view of the emerging interplay between the heart and adiposity-related diseases. In addition, this volume discusses the clinical implications and therapeutic targets of EAT in atrial fibrillation, heart failure and coronary artery disease. Comprehensive yet focused, Epicardial Adipose Tissue: From Cell to Clinic is an essential resource for physicians, residents, fellows, and medical students in cardiology, endocrinology, primary care, and health promotion and disease prevention.




Obesity and Lipotoxicity


Book Description

Due to the resultant health consequences and considerable increase in prevalence, obesity has become a major worldwide health problem. “Obesity and Lipotoxicity” is a comprehensive review of the recent researches to provide a better understanding of the lipotoxicity-related mechanisms of obesity and the potential for the development of new treatment strategies. This book overviews the biochemical pathways leading to obesity-related metabolic disorders that occur subsequent to lipotoxicity. Chapters examine the deleterious effects of nutrient excess at molecular level including the cellular and molecular aspects of breast cancer, resistance to leptin, insulin, adiponectin, and interconnection between the circadian clock and metabolic pathways during high-fat feeding. “Lipotoxicity and Obesity” will be a useful resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, cardiologists, as well as students who are thought in this field.




Insulin Resistance


Book Description

In Insulin Resistance: The Metabolic Syndrome X, outstanding investigators thoughtfully summarize our current understanding of how insulin resistance and its compensating hyperinsulinemia (Syndrome X) play a major role in the pathogenesis and clinical course of high blood pressure and cardiovascular disease-the so-called diseases of Western civilization-as well as polycystic ovary disease. Under the aegis of Gerald Reaven, the discoverer of Syndrome X, the distinguished authorities writing here detail for the first time the pathophysiological consequences and the clinical syndromes, excluding Type 2 diabetes, related to insulin resistance. They also examine the genetic and lifestyle factors that contribute to the wide differences in insulin action that exist in the population at large. Each author has been encouraged to present a point of view that reflects their unique insights. The first authoritative book on the subject, Insulin Resistance: The Metabolic Syndrome X illuminates the special importance of insulin resistance as a major cause of hypertension, heart disease, and polycystic ovary syndrome. Its thoughtful and detailed approach will make it an essential reference for basic and clinical researchers seeking to understand these critical phenomena.




Translational Research in Coronary Artery Disease


Book Description

Translational Research in Coronary Artery Disease: Pathophysiology to Treatment covers the entire spectrum of basic science, genetics, drug treatment, and interventions for coronary artery disease. With an emphasis on vascular biology, this reference fully explains the fundamental aspects of coronary artery disease pathophysiology. Included are important topics, including endothelial function, endothelial injury, and endothelial repair in various disease states, vascular smooth muscle function and its interaction with the endothelium, and the interrelationship between inflammatory biology and vascular function. By providing this synthesis of current research literature, this reference allows the cardiovascular scientist and practitioner to access everything they need from one source. - Provides a concise summary of recent developments in coronary and vascular research, including previously unpublished data - Summarizes in-depth discussions of the pathobiology and novel treatment strategies for coronary artery disease - Provides access to an accompanying website that contains photos and videos of noninvasive diagnostic modalities for evaluation of coronary artery disease




Obesity and Diabetes Mellitus


Book Description

This book is the result of the study of metabolic and hormonal disorders in patients suffering obesity and diabetes mellitus, focusing on mechanisms of formation of atherosclerotic changes in the myocardium and vessels in diabetes mellitus patient.




Obesity and Gynecology


Book Description

Obesity and Gynecology, Second Edition, presents updated chapters on a variety of topics, ranging from adolescent obesity, contraception, assisted reproduction and sexual dysfunction, to bariatric surgery and improving semen parameters. The prevalence of obesity in men and women continues to dramatically increase around the world. Obesity presents specific challenges in relation to male and female infertility and general gynecology. Patients who are obese require specific considerations and knowledge. - Presents an essential reference on the significant risks of obesity related to contraception, male and female infertility, and general gynecology - Builds foundational knowledge, showing how obesity relates to general gynecology, including menstrual disorders, breasts cancer, menopause and sexual dysfunction - Assembles critically evaluated chapters that focus on obesity and gynecology to meet the practical needs of gynecologists, endocrinologists and general practitioners




Adiponectin


Book Description

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. - Contributions from leading authorities - Informs and updates on all the latest developments in the field




Genetics, Neurology, Behavior, and Diet in Dementia


Book Description

Genetics, Neurology, Behavior, and Diet in Dementia: The Neuroscience of Dementia, Volume 2 consolidates different fields of dementia research into a single book, covering a range of subjects, including Alzheimer's disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, and molecular biology. This foundational, comprehensive book assembles the latest understanding on all dementias and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. - Offers comprehensive coverage of a broad range of topics related to dementia - Serves as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunction - Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding - Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations - Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations - Serves as a "one-stop" source for everything you need to know about dementia




Science In Medicine


Book Description

Science in Medicine: The JCI Textbook of Molecular Medicine is a collection of acclaimed articles published in the Journal of Clinical Investigation during the Journal’s tenure at Columbia University. The society that publishes the JCI, the American Society for Clinical Investigation (ASCI), is an honor society of physician scientists, representing those who are at the forefront of translating findings in the laboratory to the advancement of clinical practice. This textbook brings together state-of-the-art reviews written by the world's leading authorities, including many ASCI members. The reviews examine the molecular mechanisms underlying a wide array of diseases and disorders affecting all major organ systems. The fundamentals of the organ or physiological systems in question are present alongside the underlying genetic or physiological abnormalities that result in disease. This text illustrates the translation of basic scientific knowledge into the current practice of clinical medicine. The reviews provide an authoritative and comprehensive overview by building on known scientific concepts and treatment of human disease while exploring where these advances might take medicine over the next decade. The book is a valuable resource for medical students, graduate students, house staff, attending and practicing physicians, and biomedical researchers.