Advanced Therapies in Pediatric Endocrinology and Diabetology


Book Description

Dealing with current hot topics, this book aims to provide an update on advances in the treatment of endocrine disorders. The chapters cover innovative therapeutic approaches to type 1 diabetes, such as artificial pancreas and islet transplantation. Additionally, novel pharmacological interventions for patients with obesity and the metabolic syndrome, as well as with adrenal and gonadal disorders are provided. Furthermore, recent developments in growth-promoting therapies, such as the C-type natriuretic peptide analog to treat achondroplasia, as well as antioxidant and gene replacement therapies in patients with adrenoleukodystrophy, are described. Worldwide renowned experts share their experience and cutting edge research in Advanced Therapies in Pediatric Endocrinology and Diabetology, which makes it a useful and interesting resource for every pediatric endocrinologist, not only those active in clinical research, but also those involved in the management of children with endocrine diseases in daily practice.




Managing Pediatric Obesity Using Advanced Therapies


Book Description

Treatment of pediatric obesity, to date, has largely focused on lifestyle therapy. While lifestyle therapy is essential for obesity management, it is often insufficient, particularly for youth who have severe forms of the disease. Underlying the limitations of lifestyle therapy is the recognition that obesity is a biological disorder of the energy regulatory system and accordingly, to effectively manage obesity, the underpinning pathophysiology needs to be addressed. This pathophysiology can be targeted with more advanced therapies including anti-obesity medications and metabolic and bariatric surgery, two treatment strategies supported by the American Academy of Pediatrics. Written by leading experts in the field, A Practical Guide to Managing Pediatric Obesity is comprised of thirteen chapters, each including suggested protocols and case examples. The first chapter details the complex pathophysiology of obesity and sets the stage for why advanced therapies are critical for effective obesity management. Chapter two provides guidance on best practices for communicating with patients and families about obesity. The next three chapters provide direction on how to do a comprehensive patient assessment, and employ dietary and physical activity interventions. The heart of this guidebook is the chapter on pharmacological treatments, which details the mechanisms of action, research results, and recommendations for anti-obesity medication selection and monitoring outlined in a step-by-step fashion. Pre- and post-operative care for the pediatric bariatric surgery patient is detailed in the next chapter. Assessment and management of behavioral and psychological complications, type 2 diabetes, non-alcoholic fatty liver disease, polycystic ovary syndrome, hypertension, and dyslipidemia are covered in the subsequent five chapters. Syndromic and monogenic obesity are discussed in the final chapter.




Novelties in Diabetes


Book Description

The field of diabetes mellitus research is currently characterized by rapid and remarkable growth that has led to the development of significant diagnostic and therapeutic advances. This is very important given the fact that the frequency of the disease continues to increase at alarming rates worldwide. This new volume is a comprehensive overview of the contemporary state of the art in the field. Experts shed light on a broad range of relevant aspects, from genetic background to topics related to diabetic complications such as diabetic retinopathy or diabetic nephropathy. This is expanded upon through papers reporting on the present state of diabetes in pregnancy and on the relationship between diabetes and cancer. There is also an inventory of currently used therapeutic tools and a review of novel therapeutic approaches like incretin-based therapies or sodium-glucose transporter-2 inhibitors. Additionally, the latest technological developments such as enhanced features for blood glucose meter or continuous and implantable glucose monitoring devices are included. Providing a concise but comprehensive update, this book will be essential to every clinician involved in the treatment of diabetes mellitus.




Transition of Care


Book Description

Pediatricians face many questions and challenges during patients’ transition from childhood to adulthood. Chronic diseases justify long-term medical, psychological, educational, and social management. The establishment of networks with adult endocrinologists is, therefore, very important to achieving optimal conditions for a successful transition period. In this book, leading experts discuss major public health issues such as diabetes and obesity. They also review genetic diseases, including Turner syndrome and congenital adrenal hyperplasia. All clinical cases are presented in a focused way to highlight any issues which might be discussed by the doctor with patients and family. Psychological approaches are debated as are proposals for defining specific tools to encourage autonomy during this life period. This book is a valuable tool and will be helpful in answering many questions for endocrinologists, adult and pediatric, dedicated to the long-term management of patients with chronic diseases.




Pediatric Endocrinology


Book Description

As part of the Core Handbook Series in Pediatrics, this book provides a practical discussion of the major endocrine disorders that can be managed in the primary care setting. The book opens with a chapter on signs and symptoms in endocrine disease and then moves into specific disease chapters such as growth disorders, thyroid disorders, diabetes, and more. Each chapter consists of a brief discussion of the relevant pathophysiology and moves into diagnosis and treatment, making liberal use of tables and algorithms.




Management of Pediatric Obesity and Diabetes


Book Description

The twin epidemics of obesity and type 2 diabetes mellitus (T2DM) continue to affect an ever increasing number of children, adolescents, and young adults. Management of Pediatric Obesity and Diabetes provides healthcare trainees and professionals with practical, comprehensive, and contemporary approaches to the pediatric patient at risk for obesity, T2DM, and related conditions. A unique guide on the subject, this volume provides clinical paradigms for diagnosis and management of pediatric T2DM and related conditions, while succinctly describing state-of-the-art basic and clinical sciences underlying these problems. The chapters in this volume are independent and concise. Each chapter focuses on a key clinical issue or mechanism of disease. Providing practical, data-driven resources based upon the totality of the evidence, this important text helps the reader understand the basics of pediatric obesity and T2DM and implement strategies to prevent and treat obesity and diabetes in children and adolescents. Management of Pediatric Obesity and Diabetes provides health professionals across many areas of research and practice with up-to-date, well-referenced, and comprehensive evidence on identification, treatment, and prevention of these chronic, serious, metabolic diseases in children. This volume will serve the reader as the most authoritative resource in the field to date.




Pediatric Endocrinology and Growth


Book Description

The ability to recognize key physical signs on examination of the child is vital in the diagnosis of pediatric endocrine and growth disorders. Pediatric Endocrinology and Growth illustrates these physical signs in colour and reviews the pathophysiology, differential diagnosis and treatment for each condition, providing a concise overview of the complex sub-specialty. This illustrated text describes the physical examination and history-taking, with guides to growth charts measurement techniques and physical signs. It then focuses on specific problems, from growth disorders to glucose homeostasis, early or late sexual development abnormal genitalia, goiter, failure to thrive and obesity. Each chapter reviews the pathology and physiology of the disorders as well as the differential diagnosis and preferred treatment options. Guidance is given on which cases should be referred to a specialist pediatric endocrinologist. Concise and structured text covering all pediatric endocrine disorders at the level required by a general pediatrician or endocrinologist, giving the generalist all the key information to diagnose and treat the more common conditions. Appendices of Tests of Endocrine Function and Normal Values guide the clinician as to which test to request, and normal values aid in the interpretation of the results. Growth charts show progress of typical cases, indicating likely the outcome of similar cases that may be encountered. Treatment options discussed for each condition to guide the clinician to the appropriate treatment plan Highly illustrated with 475 figures, most in full colour to facilitate diagnosis of those cases which can sometimes be difficult to diagnose accurately, by giving visual examples as well as written descriptions Individual new chapters on Diabetes (Glucose Homeostasis), Obesity and Failure to Thrive. Benefit: these are the conditions increasing most rapidly in incidence in the field, and so being seen more and more by general pediatricians Much more on the genetic basis of endocrine and growth disorders and antenatal treatment. Benefit: now able to screen for many of these conditions and the clinician can advise parents of the possibility of further affected children. Text expanded to make the new edition an illustrated text instead of an atlas. Benefit: this edition gives much more practical clinical detail and more on treatment options than the first edition, while keeping the text succinct and focussed. Much more on treatment options, including all new therapies, while still indicating when to refer to a specialist. Benefit: gives clear treatment plans for the non-specialist and indicates when the child needs more specialist treatment. Selected references now given with each chapter. Benefit: refers reader to review articles for further detail.




Paediatric Endocrinology and Diabetes


Book Description

This handbook covers anatomy and physiology before moving on to identification, investigation and management of specific endocrine disorders. As well as covering common and less common endocrine problems, there are also chapters on endocrine investigations and endocrine emergencies, designed for quick reference.




Pediatric Endocrinology, Two Volume Set


Book Description

Celebrating more than twenty years as the single best source in the field, this Fifth Edition has now expanded into two cornerstone volumes with 53 fully inclusive chapters and 73 renowned contributors that comprehensively address every topic and trend relevant to the identification, diagnosis, and management of endocrine and endocrin




Diabetes in Children and Adolescents


Book Description

Currently, available information on pediatric and adolescent diabetes is limited to chapters in larger books covering the broader topic of pediatric endocrinology, and these do not have the space to delve into specific topics. This concise, timely book contains everything that a practicing provider needs to know in order to provide comprehensive, up-to-date care for children and adolescents with diabetes, from the latest methods for diagnosing various types of diabetes to integrating cutting-edge technology in the care of this patient population. Initial management, the use of insulin pumps, continuous glucose monitoring, and automated insulin delivery are discussed in detail, as are nutrition therapy, exercise, psychosocial challenges, acute and long-term complications, and future directions for treatment and research. Further, this book provides clinicians with guidelines for the implementation of best practices as outlined by leading associations such as the American Diabetes Association (ADA) and International Society of Pediatric and Adolescent Diabetes (ISPAD). The Yale Children’s Diabetes Program has been ranked among the best in the United States, including clinicians and researchers who are world-renowned for their efforts in improving the care of children with diabetes. This wealth of knowledge and experience positions the author team well as experts in this field.