Advances in Animal Experimentation and Modeling


Book Description

Exploration in Laboratory Animal Sciences Understanding Life Phenomena updates our knowledge about the newer technologies such as molecular biology, genomics including sequencing, proteomics, transcriptomics, cell culture, stem cell culture, transgenesis and their translation to understand systematics and phylogeny of laboratory animals at molecular level. In seven sections Exploration in Laboratory Animal Sciences Understanding Life Phenomena resolves issues of conservation, applications in environment monitoring, production of drugs and others. Comparative research has enabled use of domestic animal models that translate the advances in basic biosciences to the schemes for human welfare including medicine. Molecular geneticists are unravelling the complexities of mammalian genes and the field of biotechnology is maturing at a fast pace. Additionally, research focused on immunology and animal behavior offer new insight into ways of enhancing animal welfare. The rise in consumption of animal proteins in addition to the challenges of sustaining our natural resources has given animal scientists a vast array of opportunities to engage in integrative systems-based research for meeting the challenges that behold us. Exploration in Laboratory Animal Sciences Understanding Life Phenomena also discusses the manipulation of animals as factories for the production of safe foods, drugs, and sensors and others to meet the contemporary challenges faced by mankind in the new world order created by pandemic of Covid 19. It also includes several chapters on the causation and management of certain diseases and impact of microbes on life. - Provides insight to newer and futuristic technologies to understand disease process and drug design by animal models - Addresses a wide variety of species and covers a wide variety of topics (such as animal species, the laboratory setting, regulatory guidelines, and ethical considerations) to fully prepare for work with all types of animals - Gives a perspective on laboratory animal use that allows to explain the benefits of animal use as required by veterinary technology program accreditation procedure - Includes examples of animal bio-technological techniques (including stem cell and tissue engineering) for their applications to humanity - Offers new insight into ways of enhancing animal welfare by the inclusion of research results focused on immunology and laboratory animal behavior




Use of Laboratory Animals in Biomedical and Behavioral Research


Book Description

Scientific experiments using animals have contributed significantly to the improvement of human health. Animal experiments were crucial to the conquest of polio, for example, and they will undoubtedly be one of the keystones in AIDS research. However, some persons believe that the cost to the animals is often high. Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of animal welfare, and the prospects for finding alternatives to animal use. The authors conclude with specific recommendations for more consistent government action.




Animal Experimentation


Book Description

Animal Experimentation: Working Towards a Paradigm Change critically appraises current animal use in science and discusses ways in which we can contribute to a paradigm change towards human-biology based approaches.




Principles of Animal Research for Graduate and Undergraduate Students


Book Description

Principles of Animal Research is the first publication to offer a broad look at animal research science for a student, early researcher, or technician. Offering guidance for all aspects of the research experience, including the research and development of a thesis, model selection, experimental design, IACUC protocol preparation, and animal husbandry and technical procedural needs, the book is a necessary addition to every student, technician, and researcher's education. - Provides background material for students to understand the broader backdrop against which animal research is undertaken - Includes ethical and regulatory information - Covers commonly used animal models and the process to choose a model for biomedical research




Science, Medicine, and Animals


Book Description

The necessity for animal use in biomedical research is a hotly debated topic in classrooms throughout the country. Frequently teachers and students do not have access to balanced,  factual material to foster an informed discussion on the topic. This colorful, 50-page booklet is designed to educate teenagers about the role of animal research in combating disease, past and present; the perspective of animal use within the whole spectrum of biomedical research; the regulations and oversight that govern animal research; and the continuing efforts to use animals more efficiently and humanely.




International Animal Research Regulations


Book Description

Animals are widely used in neuroscience research to explore biological mechanisms of nervous system function, to identify the genetic basis of disease states, and to provide models of human disorders and diseases for the development of new treatments. To ensure the humane care and use of animals, numerous laws, policies, and regulations are in place governing the use of animals in research, and certain animal regulations have implications specific to neuroscience research. To consider animal research regulations from a global perspective, the IOM Forum on Neuroscience and Nervous System Disorders, in collaboration with the National Research Council and the Institute for Laboratory Animal Research, held a workshop in Buckinghamshire, UK, July 26-27, 2011. The workshop brought together neuroscientists, legal scholars, administrators, and other key stakeholders to discuss current and emerging trends in animal regulations as they apply to the neurosciences. This document summarizes the workshop.




Animal Models in Eye Research


Book Description

The eye is a complex sensory organ, which enables visual perception of the world. Thus the eye has several tissues that do different tasks. One of the most basic aspects of eye function is the sensitivity of cells to light and its transduction though the optic nerve to the brain. Different organisms use different ways to achieve these tasks. In this sense, eye function becomes a very important evolutionary aspect as well. This book presents the different animal models that are commonly used for eye research and their uniqueness in evaluating different aspects of eye development, evolution, physiology and disease. - Presents information on the major animal models used in eye research including invertebrates and vertebrates - Provides researchers with information needed to choose between model organisms - Includes an introductory chapter on the different types of eyes, stressing possible common molecular machinery




Science, Medicine, and Animals


Book Description

Science, Medicine, and Animals explains the role that animals play in biomedical research and the ways in which scientists, governments, and citizens have tried to balance the experimental use of animals with a concern for all living creatures. An accompanying Teacher's Guide is available to help teachers of middle and high school students use Science, Medicine, and Animals in the classroom. As students examine the issues in Science, Medicine, and Animals, they will gain a greater understanding of the goals of biomedical research and the real-world practice of the scientific method in general. Science, Medicine, and Animals and the Teacher's Guide were written by the Institute for Laboratory Animal Research and published by the National Research Council of the National Academies. The report was reviewed by a committee made up of experts and scholars with diverse perspectives, including members of the U.S. Department of Agriculture, National Institutes of Health, the Humane Society of the United States, and the American Society for the Prevention of Cruelty to Animals. The Teacher's Guide was reviewed by members of the National Academies' Teacher Associates Network. Science, Medicine, and Animals is recommended by the National Science Teacher's Association NSTA Recommends.




The Costs and Benefits of Animal Experiments


Book Description

A comprehensive review of recent scientific evidence examining the contributions of animal experimentation to human healthcare. The book also explores toxicity prediction, animal use during life and health sciences education, impacts on student attitudes toward animals, and the extent to which animals suffer in laboratories.




The Design of Animal Experiments


Book Description

Where there is no alternative to the use of animals in biomedical research, it is important that experiments are well designed and correctly analysed in order to minimise pain and maximize the chance of getting scientifically valid results. Experiments that use too few animals may fail to pick up biologically important effects, while those who use them incorrectly or wastefully may get invalid results while subjecting the animals to unnecessary pain, distress or lasting harm. The Design of Animal Experiments is intended for all research scientists who use laboratory animals, with the aim of helping them to design their own experiments more effectively and/or to improve their ability to communicate with professional statisticians when necessary. It covers all randomised controlled experimental designs likely to be needed in laboratory animal research, with worked examples showing how they can be statistically analysed. It suggests the more widespread use of randomised block designs and shows how both males and females can be included in an experiment without the need to increase the total number of animals by using factorial designs. It also includes guidance on the choice of experimental animals. The book covers the learning outcomes of Module 10 and part (ii) of Module 11 of education and training under Directive 2010/63/EU.