Advances in Chemical Biology – An Overview of Research Milestones and Applications (Volume – II) Book


Book Description

The current book emphasizes on basic knowledge of chemistry and biology concepts, covering multidisciplinary applications which comprises functional aspects of chemical and biological disciplines and they are resource material for young innovative minds to enhance their knowledge and research thoughts as a creative element to apply it in their research in the field of chemical biology. The main motto of this book highlights on research objectives, new developments of synthesis, a wide range of applications, and as per the industrial requirements for a useful product to launch or discover for science and society. Various innovations are the major source and new perspectives to troubleshoot the newer problems with the help of allied science applications by understanding the basic concepts, theories, protocols, needful technologies, and applied products, by knowing similar problems and their impact in current-day problems in the science field. Hence, it’s interdisciplinary research to develop highly significant pharmacology products in the areas of life science to make sure safer, cheaper, and ecological as a novel future drug/medicine. The applications aimed mainly to health of humans, health of agro-horticulture, health of environment and animalsas well as wealth of entrepreneurs. This comprehensive edited volume summarises the features of An Approach to Future Perspectives for academic, research and industrial purposes as an advanced reference material for all the learners in the area of chemistry and biology.




Advances in Chemical Biology – An Approach In Future Perspectives Volume – 3


Book Description

Advances in Chemical Biology – Volume 3 The current book summary envisages the basic aspects of chemistry and biology thoughts, with the allied area of multidiscipline which comprises applications of chemical and biological disciplines and these are significant literatureto innovative minds to enrich their knowledge by research topics as anilluminative element to focus it in their research studies in the field of sciences. The book highlights research objectives on synthetic chemistry, newer approach of synthesis process and their various applications in in vitro and in vivo level as per the pharmaceutical industry requirements for commercialize the product to cure the various diseases and ailments for science and society. Recent innovations are highly applied and as per the demand of pharma sector and these are new perspectives to troubleshoot the newer problems with the help of molecular approach and bioinformatics applications.Understanding by the assimilation of basic to applied core research concepts in chemistry and their allied branches brings many applications, using novel methodologies, classic principles, defined protocols, emerging technologies by knowing similar issues and their impact in current-day problems in the science field. Hence, it’s multidisciplinary research to emphasize novel synthetic molecules which exhibit to safer, cheaper, and ecological drug for futuremedicine. The applications aimed on humans and animals as an important therapeutic drug for pharma industry. It is highly comprehensive book volume summarising various features of An Approach to Future Perspectives for academic research and industrial research in advanced level for all the learners in the area of chemistry and biology. It would be the best literature for the researchers and it can be a key reference book for the findings of new research problems to work for new drug discovery. This book has been peer-reviewed and free from plagiarism; hence it is highly useful for science and technology. It’s our great pleasure to wish all the readers, researchers, and industrialists to utilize it to accomplish new milestones as an innovation and novel discovery for future perspectives.




Bio-Ceramics with Clinical Applications


Book Description

This publication offers a unique approach that links the materials science of bioceramics to clinical needs and applications. Providing a structured account of this highly active area of research, the book reviews the clinical applications in bone tissue engineering, bone regeneration, joint replacement, drug-delivery systems and biomimetism, this book is an ideal resource for materials scientists and engineers, as well as for clinicians. From the contents: Part I Introduction 1. Bioceramics 2. Biomimetics Part II Materials 3. Calcium Phosphate Bioceramics 4. Silica-based Ceramics: Glasses 5. Silica-based Ceramics: Mesoporous Silica 6. Alumina, Zirconia, and Other Non-oxide Inert Bioceramics 7. Carbon-based Materials in Biomedicine Part III Material Shaping 8. Cements 9. Bioceramic Coatings for Medical Implants 10. Scaffold Designing Part IV Research on Future Ceramics 11. Bone Biology and Regeneration 12. Ceramics for Drug Delivery 13. Ceramics for Gene Transfection 14. Ceramic Nanoparticles for Cancer Treatment




Drug Discovery and Development, Volume 2


Book Description

From first principles to real-world applications-here is the first comprehensive guide to drug discovery and development Modern drug discovery and development require the collaborative efforts of specialists in a broadarray of scientific, technical, and business disciplines-from biochemistry to molecular biology, organic chemistry to medicinal chemistry, pharmacology to marketing. Yet surprisingly, until now, there were no authoritative references offering a complete, fully integrated picture of the process. The only comprehensive guide of its kind, this groundbreaking two-volume resource provides an overview of the entire sequence of operations involved in drug discovery and develop-?ment-from initial conceptualization to commercialization to clinicians and medical practitioners. Volume 1: Drug Discovery describes all the steps in the discovery process, including conceptualizing a drug, creating a library of candidates for testing, screening candidates for in vitro and in vivo activity, conducting and analyzing the results of clinical trials, and modifying a drug as necessary. Volume 2: Drug Development delves into the nitty-gritty details of optimizing the synthetic route, drug manufacturing, outsourcing, and marketing-including drug coloring and delivery methods. Featuring contributions from a world-class team of experts, Drug Discovery and Development: Features fascinating case studies, including the discovery and development of erythromycin analogs, Tagamet, and Ultiva (remifentanil) Discusses the discovery of medications for bacterial infections, Parkinson's disease, psoriasis, peptic ulcers, atopic dermatitis, asthma, and cancer Includes chapters on combinatorial chemistry, molecular biology-based drug discovery, genomics, and chemogenomics Drug Discovery and Development is an indispensable working resource for industrial chemists, biologists, biochemists, and executives who work in the pharmaceutical industry.










OUR FRAGILE WORLD: Challenges and Opportunities for Sustainable Development - Volume II


Book Description

This publication, Our Fragile World: Challenges and Opportunities for Sustainable Development presents perspectives of several important subjects that are covered in greater detail and depth in the Encyclopedia of Life Support Systems (EOLSS). The contributions to the two volumes provide an integrated presentation of knowledge and worldviews related to the state of: Earth's natural resources, social resources, institutional resources, and economic and financial resources. They present the vision and thinking of over 200 authors in support of efforts to solve the complex problems connected with sustainable development, and to secure perennial life support on "The Blue Planet'. These contributions are holistic, informative, forward looking, and will be of interest to a broad readership. This volume presents contributions with focus on the Economic and Institutional Dimensions of Sustainable Development in two sections: KNOWLEDGE, TECHNOLOGY, AND MANAGEMENT (Knowledge; Technology and Management ; Economics; Finance and trade). – POLICY AND INSITUTIONAL IMPLICATIONS FOR SUSTAINABLE DEVELOPMENT (Policy Issues; Institutional implications; Regional Analysis).




Industrialization of Biology


Book Description

The tremendous progress in biology over the last half century - from Watson and Crick's elucidation of the structure of DNA to today's astonishing, rapid progress in the field of synthetic biology - has positioned us for significant innovation in chemical production. New bio-based chemicals, improved public health through improved drugs and diagnostics, and biofuels that reduce our dependency on oil are all results of research and innovation in the biological sciences. In the past decade, we have witnessed major advances made possible by biotechnology in areas such as rapid, low-cost DNA sequencing, metabolic engineering, and high-throughput screening. The manufacturing of chemicals using biological synthesis and engineering could expand even faster. A proactive strategy - implemented through the development of a technical roadmap similar to those that enabled sustained growth in the semiconductor industry and our explorations of space - is needed if we are to realize the widespread benefits of accelerating the industrialization of biology. Industrialization of Biology presents such a roadmap to achieve key technical milestones for chemical manufacturing through biological routes. This report examines the technical, economic, and societal factors that limit the adoption of bioprocessing in the chemical industry today and which, if surmounted, would markedly accelerate the advanced manufacturing of chemicals via industrial biotechnology. Working at the interface of synthetic chemistry, metabolic engineering, molecular biology, and synthetic biology, Industrialization of Biology identifies key technical goals for next-generation chemical manufacturing, then identifies the gaps in knowledge, tools, techniques, and systems required to meet those goals, and targets and timelines for achieving them. This report also considers the skills necessary to accomplish the roadmap goals, and what training opportunities are required to produce the cadre of skilled scientists and engineers needed.




Cheminformatics and its Applications


Book Description

Cheminformatics has emerged as an applied branch of Chemistry that involves multidisciplinary knowledge, connecting related fields such as chemistry, computer science, biology, pharmacology, physics, and mathematical statistics.The book is organized in two sections, including multiple aspects related to advances in the development of informatic tools and their specific use in compound structure databases with various applications in life sciences, mainly in medicinal chemistry, for identification and development of new therapeutically active molecules. The book covers aspects related to genomic analysis, semantic similarity, chemometrics, pattern recognition techniques, chemical reactivity prediction, drug-likeness assessment, bioavailability, biological target recognition, machine-based drug discovery and design. Results from various computational tools and methods are discussed in the context of new compound design and development, sharing promising opportunities, and perspectives.