Advances in Order Restricted Statistical Inference


Book Description

With support from the University of Iowa and the Office of Naval Research. a small conference on order restricted inference was held at the University of Iowa in Iowa City in April of 1981. There were twenty-one participants. mostly from the midwest. and eleven talks were presented. A highlight of the conference was a talk by D. J. Bartholomew on. "Reflections on the past and thoughts about the future. " The conference was especially valuable because it brought together researchers who were thinking about related problems. A small conference on a limited topic is one of the best ways to stimulate research and facilitate collaboration. Because of the success of the first conference. a second conference was organized and held in September of 1985. This second conference was made possible again by support from the Office of Naval Research under Department of the Navy Contract NOOOI4-85-0161 and the University of Iowa. There were thirty-five participants and twenty presentations on a wide variety of topics dealing with order restricted inference at the second conference. This volume is a collection of fourteen of those presentations. By collecting together and organizing the fundamental results in order restricted inference in Statistical Inference under Order Restrictions. R. E. Barlow. D. J. Bartholomew. J. M. Bremner and H. D. Brunk have done much to stimulate research in this area. and so we wish to express our gratitude to them first.




Constrained Statistical Inference


Book Description

An up-to-date approach to understanding statistical inference Statistical inference is finding useful applications in numerous fields, from sociology and econometrics to biostatistics. This volume enables professionals in these and related fields to master the concepts of statistical inference under inequality constraints and to apply the theory to problems in a variety of areas. Constrained Statistical Inference: Order, Inequality, and Shape Constraints provides a unified and up-to-date treatment of the methodology. It clearly illustrates concepts with practical examples from a variety of fields, focusing on sociology, econometrics, and biostatistics. The authors also discuss a broad range of other inequality-constrained inference problems that do not fit well in the contemplated unified framework, providing a meaningful way for readers to comprehend methodological resolutions. Chapter coverage includes: Population means and isotonic regression Inequality-constrained tests on normal means Tests in general parametric models Likelihood and alternatives Analysis of categorical data Inference on monotone density function, unimodal density function, shape constraints, and DMRL functions Bayesian perspectives, including Stein’s Paradox, shrinkage estimation, and decision theory







Order Restricted Statistical Inference


Book Description

This work attempts to provide a comprehensive treatment of the topic of statistical inference under inequality constraints, in which much of the theory is based on the principles ofr maximum likelihood estimation and likelihood ratio tests.




Ranking of Multivariate Populations


Book Description

Ranking of Multivariate Populations: A Permutation Approach with Applications presents a novel permutation-based nonparametric approach for ranking several multivariate populations. Using data collected from both experimental and observation studies, it covers some of the most useful designs widely applied in research and industry investigations, such as multivariate analysis of variance (MANOVA) and multivariate randomized complete block (MRCB) designs. The first section of the book introduces the topic of ranking multivariate populations by presenting the main theoretical ideas and an in-depth literature review. The second section discusses a large number of real case studies from four specific research areas: new product development in industry, perceived quality of the indoor environment, customer satisfaction, and cytological and histological analysis by image processing. A web-based nonparametric combination global ranking software is also described. Designed for practitioners and postgraduate students in statistics and the applied sciences, this application-oriented book offers a practical guide to the reliable global ranking of multivariate items, such as products, processes, and services, in terms of the performance of all investigated products/prototypes.




Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R


Book Description

This book focuses on the analysis of dose-response microarray data in pharmaceutical settings, the goal being to cover this important topic for early drug development experiments and to provide user-friendly R packages that can be used to analyze this data. It is intended for biostatisticians and bioinformaticians in the pharmaceutical industry, biologists, and biostatistics/bioinformatics graduate students. Part I of the book is an introduction, in which we discuss the dose-response setting and the problem of estimating normal means under order restrictions. In particular, we discuss the pooled-adjacent-violator (PAV) algorithm and isotonic regression, as well as inference under order restrictions and non-linear parametric models, which are used in the second part of the book. Part II is the core of the book, in which we focus on the analysis of dose-response microarray data. Methodological topics discussed include: • Multiplicity adjustment • Test statistics and procedures for the analysis of dose-response microarray data • Resampling-based inference and use of the SAM method for small-variance genes in the data • Identification and classification of dose-response curve shapes • Clustering of order-restricted (but not necessarily monotone) dose-response profiles • Gene set analysis to facilitate the interpretation of microarray results • Hierarchical Bayesian models and Bayesian variable selection • Non-linear models for dose-response microarray data • Multiple contrast tests • Multiple confidence intervals for selected parameters adjusted for the false coverage-statement rate All methodological issues in the book are illustrated using real-world examples of dose-response microarray datasets from early drug development experiments.




Robust Statistics, Data Analysis, and Computer Intensive Methods


Book Description

To celebrate Peter Huber's 60th birthday in 1994, our university had invited for a festive occasion in the afternoon of Thursday, June 9. The invitation to honour this outstanding personality was followed by about fifty colleagues and former students from, mainly, allover the world. Others, who could not attend, sent their congratulations by mail and e-mail (P. Bickel:" ... It's hard to imagine that Peter turned 60 ... "). After a welcome address by Adalbert Kerber (dean), the following lectures were delivered. Volker Strassen (Konstanz): Almost Sure Primes and Cryptography -an Introduction Frank Hampel (Zurich): On the Philosophical Foundations of Statistics 1 Andreas Buja (Murray Hill): Projections and Sections High-Dimensional Graphics for Data Analysis. The distinguished speakers lauded Peter Huber a hard and fair mathematician, a cooperative and stimulating colleague, and an inspiring and helpful teacher. The Festkolloquium was surrounded with a musical program by the Univer 2 sity's Brass Ensemble. The subsequent Workshop "Robust Statistics, Data Analysis and Computer Intensive Methods" in Schloss Thurnau, Friday until Sunday, June 9-12, was organized about the areas in statistics that Peter Huber himself has markedly shaped. In the time since the conference, most of the contributions could be edited for this volume-a late birthday present-that may give a new impetus to further research in these fields.




Smoothness Priors Analysis of Time Series


Book Description

Smoothness Priors Analysis of Time Series addresses some of the problems of modeling stationary and nonstationary time series primarily from a Bayesian stochastic regression "smoothness priors" state space point of view. Prior distributions on model coefficients are parametrized by hyperparameters. Maximizing the likelihood of a small number of hyperparameters permits the robust modeling of a time series with relatively complex structure and a very large number of implicitly inferred parameters. The critical statistical ideas in smoothness priors are the likelihood of the Bayesian model and the use of likelihood as a measure of the goodness of fit of the model. The emphasis is on a general state space approach in which the recursive conditional distributions for prediction, filtering, and smoothing are realized using a variety of nonstandard methods including numerical integration, a Gaussian mixture distribution-two filter smoothing formula, and a Monte Carlo "particle-path tracing" method in which the distributions are approximated by many realizations. The methods are applicable for modeling time series with complex structures.




Wavelets and Statistics


Book Description

Despite its short history, wavelet theory has found applications in a remarkable diversity of disciplines: mathematics, physics, numerical analysis, signal processing, probability theory and statistics. The abundance of intriguing and useful features enjoyed by wavelet and wavelet packed transforms has led to their application to a wide range of statistical and signal processing problems. On November 16-18, 1994, a conference on Wavelets and Statistics was held at Villard de Lans, France, organized by the Institute IMAG-LMC, Grenoble, France. The meeting was the 15th in the series of the Rencontres Pranco-Belges des 8tatisticiens and was attended by 74 mathematicians from 12 different countries. Following tradition, both theoretical statistical results and practical contributions of this active field of statistical research were presented. The editors and the local organizers hope that this volume reflects the broad spectrum of the conference. as it includes 21 articles contributed by specialists in various areas in this field. The material compiled is fairly wide in scope and ranges from the development of new tools for non parametric curve estimation to applied problems, such as detection of transients in signal processing and image segmentation. The articles are arranged in alphabetical order by author rather than subject matter. However, to help the reader, a subjective classification of the articles is provided at the end of the book. Several articles of this volume are directly or indirectly concerned with several as pects of wavelet-based function estimation and signal denoising.




Athens Conference on Applied Probability and Time Series Analysis


Book Description

The Athens Conference on Applied Probability and Time Series in 1995 brought together researchers from across the world. The published papers appear in two volumes. Volume II presents papers on time series analysis, many of which were contributed to a meeting in March 1995 partly in honour of E.J. Hannan. The initial paper by P.M. Robinson discusses Ted Hannan's researches and their influence on current work in time series analysis. Other papers discuss methods for finite parameter Gaussian models, time series with infinite variance or stable marginal distribution, frequency domain methods, long range dependent processes, nonstationary processes, and nonlinear time series. The methods presented can be applied in a number of fields such as statistics, applied mathematics, engineering, economics and ecology. The papers include many of the topics of current interest in time series analysis and will be of interest to a wide range of researchers.