Translational Pain Research


Book Description

One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practical




Relieving Pain in America


Book Description

Chronic pain costs the nation up to $635 billion each year in medical treatment and lost productivity. The 2010 Patient Protection and Affordable Care Act required the Department of Health and Human Services (HHS) to enlist the Institute of Medicine (IOM) in examining pain as a public health problem. In this report, the IOM offers a blueprint for action in transforming prevention, care, education, and research, with the goal of providing relief for people with pain in America. To reach the vast multitude of people with various types of pain, the nation must adopt a population-level prevention and management strategy. The IOM recommends that HHS develop a comprehensive plan with specific goals, actions, and timeframes. Better data are needed to help shape efforts, especially on the groups of people currently underdiagnosed and undertreated, and the IOM encourages federal and state agencies and private organizations to accelerate the collection of data on pain incidence, prevalence, and treatments. Because pain varies from patient to patient, healthcare providers should increasingly aim at tailoring pain care to each person's experience, and self-management of pain should be promoted. In addition, because there are major gaps in knowledge about pain across health care and society alike, the IOM recommends that federal agencies and other stakeholders redesign education programs to bridge these gaps. Pain is a major driver for visits to physicians, a major reason for taking medications, a major cause of disability, and a key factor in quality of life and productivity. Given the burden of pain in human lives, dollars, and social consequences, relieving pain should be a national priority.




Pain Management and the Opioid Epidemic


Book Description

Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.




Psychological Methods of Pain Control


Book Description

Remarkable progress has been made in understanding both the psychological factors that influence pain, including attention, emotions and expectation, and psychological methods of pain control, such as hypnosis. This progress has several sources, including improved designs of both experimental and clinical studies and the interface of brain imaging with thoughtful questions. We have learned that pain can be powerfully influenced by addressing factors that pertain to the patients' perception of treatments. This book explains fundamental principles underlying the psychological control of pain. Understanding these principles fulfills an important need for those seeking a scientific understanding of pain control, as well as for those who treat pain patients.







Advances in Pain Research


Book Description

This book summarizes the latest advances in pain research. All the chapters were contributed by speakers from Asian Pain Symposium (APS) on Acute and Chronic Pain, which was held in Taipei in 2017. Founded in Kyoto, Japan in 2000, the APS serves as a platform for scientists to present recent findings in pain research and discuss research orientation in this field. APS 2017 focused on novel strategies for pain treatment. Written by experts from various disciplines, from molecular to functional, and from basic to clinic studies, this book is composed of 18 review articles on the physiology and pathology of pain in these research fields. Specific topics include circuitry, neurotransmitter, physiology, behavior, neuropathology, pharmacology, and the treatments for neuropathic pain disorders. The book is a valuable resource for researchers and graduate students in pain medicine and neuroscience.




The Management of Pain


Book Description

This new, clinically oriented reference provides an authoritative and up-to-date overview of interdisciplinary pain management. It delivers concise, yet comprehensive coverage of pathophysiology, diagnosis, and clinical management of acute pain, chronic benign pain, and cancer pain in adults and children. Focuses on key concepts and essential information Includessummaries of the most criticl points of each particular pain syndrome Covers rarely addressed issues essential to pain management such as nociception, the pain-oriented neurological examination, organisation and reimbursement issues and pain and health care policy Reflects the modern, interdisceplinary, anesthesiology-driven approach to the subject Features a broad scope that enables it to be used as both an accessible reference source and as a review text for broad certification.




Chronic Pain Management in General and Hospital Practice


Book Description

This book covers a range of topics, from the cause and identity of pain, to pain relief management. Starting from the mechanism of pain, it continues to pain management techniques such as nerve blocks, drugs (pain killers), noninvasive manipulations psychological techniques and electric management, before describing the management of various painful conditions such as headaches, back pain, extremities pain, post-herpetic pain or complex regional pain syndrome. It also provides the format of case reports which can be used to explain management options. A novel feature of the book is that it provides additional insights into how clinicians involve patients in treating their own pain through guided self-assessment and self-management. Recent studies have revealed that pain is not only a biological alarm that warns of disease, but can also be the disease itself, or the catalyst of a vicious circle of pain and disease. Providing rapid pain relief is often effective in sparking the rapid recovery from various diseases. This book offers the perfect guide for all clinicians, not only those working at pain clinics but all those who have to treat patients who are in pain.




Pain and Disability


Book Description

Painâ€"it is the most common complaint presented to physicians. Yet pain is subjectiveâ€"it cannot be measured directly and is difficult to validate. Evaluating claims based on pain poses major problems for the Social Security Administration (SSA) and other disability insurers. This volume covers the epidemiology and physiology of pain; psychosocial contributions to pain and illness behavior; promising ways of assessing and measuring chronic pain and dysfunction; clinical aspects of prevention, diagnosis, treatment, and rehabilitation; and how the SSA's benefit structure and administrative procedures may affect pain complaints.




Chronic Pain and Brain Abnormalities


Book Description

It is only natural for someone in pain to attend to the body part that hurts. Yet this book tells the story of persistent pain having negative effects on brain function. The contributors, all leading experts in their respective fields of pain electrophysiology, brain imaging, and animal models of pain, strive to synthesize compelling and, in some ways, connected hypotheses with regard to pain-related changes in the brain. Together, they contribute their clinical, academic, and theoretical expertise in a comprehensive overview that attempts to define the broader philosophical context of pain (disentangling sensical from nonsensical claims), list the changes known to take place in the brains of individuals with chronic pain and animal models of pain, address the possible causes and mechanisms underlying these changes, and detail the techniques and analytical methods at our disposal to "visualize" and study these changes. - Philosophical and social concepts of pain; testimonials of chronic-pain patients - Clinical data from pain patients' brains - Advances in noninvasive brain imaging for pain patients - Combining theoretical and empirical approaches to the analysis of pain-related brain function - Manipulation of brain function in animal models - Emerging neurotechnology principles for pain diagnostics and therapeutics