Author : American Psychiatric Association
Publisher : American Psychiatric Pub
Page : 220 pages
File Size : 33,38 MB
Release : 2016
Category : Medical
ISBN : 0890426775
The guideline offers clear, concise, and actionable recommendation statements to help clinicians to incorporate recommendations into clinical practice, with the goal of improving quality of care. Each recommendation is given a rating that reflects the level of confidence that potential benefits of an intervention outweigh potential harms.
Author : Ahmed Moustafa
Publisher : Academic Press
Page : 256 pages
File Size : 21,68 MB
Release : 2021-08-28
Category : Psychology
ISBN : 0128213353
Nearly 44 million people have Alzheimer's or related dementia worldwide, according to the Alzheimer's Disease International organization. That number is expected to double every 20 years. Unlike other books on the market, Alzheimer's Disease: Understanding Biomarkers, Big Data, and Therapy covers recent advancements in cognitive, clinical, neural, and therapeutic aspects of Alzheimer's and other forms of dementia.First, readers are introduced to cognitive and clinical studies, focusing on the different types of memory impairment, past and future thinking. This includes the prevalence of depression, its relationship to other symptoms, and the quality of life for those with Alzheimer's disease. In addition, the book discusses recent studies on memory dysfunction in advanced-stage Alzheimer's disease, in comparison to early-stage, including a chapter on the underlying factors in the transition from mild cognitive impairment to Alzheimer's diagnosis. Following this section, the book presents recent studies on the role of different cortical and subcortical structures in the development of various symptoms in Alzheimer's disease, as well as different neural biomarkers underlying the development and treatment of the disease. In the last section of the book, therapeutic aspects of Alzheimer's disease, focusing on behavioral and pharmacological treatments of sleep disorders, memory problems, and depression, are reviewed. The book aids readers in understanding the advances in research and care, making it a prime tool for all clinicians, psychologists, researchers, neurologists, and caregivers of dementia patients. - Reviews recent developments of cognitive and clinical studies - Covers factors underlying the transition from mild cognitive impairment to Alzheimer's disease - Discusses different neural biomarkers underlying the development and treatment of Alzheimer's disease - Provides a comparison of the effectiveness of various types of treatments
Author : Walter George Bradley
Publisher :
Page : 1672 pages
File Size : 30,99 MB
Release : 2004
Category : Diagnosis
ISBN : 9780750674690
New edition, completely rewritten, with new chapters on endovascular surgery and mitochrondrial and ion channel disorders.
Author : Jason Karlawish
Publisher : St. Martin's Press
Page : 269 pages
File Size : 15,15 MB
Release : 2021-02-23
Category : Health & Fitness
ISBN : 1250218748
A definitive and compelling book on one of today's most prevalent illnesses. In 2020, an estimated 5.8 million Americans had Alzheimer’s, and more than half a million died because of the disease and its devastating complications. 16 million caregivers are responsible for paying as much as half of the $226 billion annual costs of their care. As more people live beyond their seventies and eighties, the number of patients will rise to an estimated 13.8 million by 2050. Part case studies, part meditation on the past, present and future of the disease, The Problem of Alzheimer's traces Alzheimer’s from its beginnings to its recognition as a crisis. While it is an unambiguous account of decades of missed opportunities and our health care systems’ failures to take action, it tells the story of the biomedical breakthroughs that may allow Alzheimer’s to finally be prevented and treated by medicine and also presents an argument for how we can live with dementia: the ways patients can reclaim their autonomy and redefine their sense of self, how families can support their loved ones, and the innovative reforms we can make as a society that would give caregivers and patients better quality of life. Rich in science, history, and characters, The Problem of Alzheimer's takes us inside laboratories, patients' homes, caregivers’ support groups, progressive care communities, and Jason Karlawish's own practice at the Penn Memory Center.
Author : Harald Hampel
Publisher : Karger Medical and Scientific Publishers
Page : 200 pages
File Size : 17,50 MB
Release : 2012
Category : Medical
ISBN : 3805598025
How current biomarkers are modernizing the diagnosis of Alzheimer's disease Expanding knowledge on genetic and epigenetic risk factors is rapidly enhancing our understanding of the complex molecular interactions and systems involved in the pathogenesis of Alzheimer's disease. In this publication, leading experts discuss emerging novel conceptual models of the disease along with advances in the development of surrogate markers that will not only improve the accuracy of diagnostic technologies but also improve the prospects of developing disease-modifying interventions. The novel framework of the disease presented here highlights research on biological markers as well as efforts to validate technologies for early and accurate detection. It also introduces notion of a complex systems dysfunction that extends beyond prevailing ideas derived from the amyloid' or tau' hypotheses. This outstanding publication provides researchers, clinicians, students and other professionals interested in neurodegenerative disorders with a comprehensive update on current trends and future directions in therapy development, with special focus on advances in clinical trial designs.
Author : Magisetty Obulesu
Publisher : Academic Press
Page : 81 pages
File Size : 22,14 MB
Release : 2019-01-20
Category : Medical
ISBN : 0128167394
Alzheimer's Disease Theranostics discusses the latest information on recent theranostic avenues for both the diagnosis and treatment of Alzheimer's patients. It presents the pros and cons of the probable mechanistic role of nanoparticles in crossing the blood-brain barrier and improving disease symptoms. Finally, it highlights the merits of existing maneuvers and suggests perspectives to aid in future developments. Despite the difficulty of drug delivery to the brain, there are some nanoparticulate platforms demonstrating promise in treating neurodegenerative disorders such as Alzheimer's disease. Manifold theranostic maneuvers include antioxidants, natural bioactive compounds, gene therapy, and nanotechnological approaches, all of which are discussed in this important work. - Examines various theranostic applications for the diagnosis and treatment of Alzheimer's disease - Features a comprehensive overview of nanoparticle therapeutics in the area and use of antioxidants - Assesses the common challenges and lessons learned from blood-brain barrier challenges, viral vector approaches and mitochondria-targeted therapeutics
Author : Marianne Boenink
Publisher : Springer
Page : 300 pages
File Size : 44,89 MB
Release : 2016-09-13
Category : Social Science
ISBN : 1137540974
This book explores international biomedical research and development on the early diagnosis of Alzheimer's disease. It offers timely, multidisciplinary reflections on the social and ethical issues raised by promises of early diagnostics and asks under which conditions emerging diagnostic technologies can be considered a responsible innovation. The initial chapters in this edited volume provide an overview and a critical discussion of recent developments in biomedical research on Alzheimer's disease. Subsequent contributions explore the values at stake in current practices of dealing with Alzheimer's disease and dementia, both within and outside the biomedical domain. Novel diagnostic technologies for Alzheimer's disease emerge in a complex and shifting field, full of controversies. Innovating with care requires a precise mapping of how concepts, values and responsibilities are filled in through the confrontation of practices. In doing so, the volume offers a practice-based approach of responsible innovation that is also applicable to other fields of innovation.
Author : Athanasios Alexiou
Publisher : Frontiers Media SA
Page : 501 pages
File Size : 19,18 MB
Release : 2019-12-04
Category :
ISBN : 2889631281
Alzheimer’s disease is undoubtedly the major health challenge of our Century with significant social and economic consequences. This Frontiers eBook offers a contribution of 39 innovative papers on the multidimensional and crucial problem of Alzheimer’s disease management and treatment. Several perspectives, research updates, and trials describing methods on potential diagnosis and treatment are presented including biological mechanisms, biomarkers and risk factors for an early and efficient prognosis, diagnosis and prevention. Additionally, while the rapidly increasing Alzheimer’s disease population demands holistic solutions and clinical studies with new therapeutic target approaches, several of the contributive papers present promising drugs targeting Alzheimer’s disease treatment. We give our deepest acknowledgment to all the authors for their important and innovative contributions, to the reviewers for their valuable recommendations on improving the submitting studies and all the Frontiers Editorial team for continuous support.
Author : Jeffrey Cummings
Publisher : Cambridge University Press
Page : 575 pages
File Size : 28,89 MB
Release : 2022-03-31
Category : Business & Economics
ISBN : 1108838669
Provides a definitive overview of the complex ecosystem facilitating Alzheimer's Disease drug research and development. Demonstrates a drug's journey from in the lab, clinical trial testing, regulatory review, and marketing by pharmaceutical companies. Details the use of artificial intelligence, clinical trial management, and financing models.
Author : Tapan Khan
Publisher : Academic Press
Page : 278 pages
File Size : 28,87 MB
Release : 2016-08-02
Category : Psychology
ISBN : 0128051477
Biomarkers in Alzheimer's Disease provides a comprehensive overview of all modalities of Alzheimer's disease biomarkers, including neuroimaging, cerebrospinal fluid, genomic, and peripheral systems. Each chapter integrates molecular/cellular abnormality due to Alzheimer's disease and technological advancement of biomarkers techniques. The book is ideal for clinical neuroscience and molecular/cellular neuroscience researchers, psychiatrists, and allied healthcare practitioners involved in the diagnosis and management of patients with cognitive impairment and Alzheimer's disease, and for differential diagnosis of Alzheimer's disease with other non-Alzheimer's dementia. - Presents a comprehensive overview detailing all modalities of Alzheimer's disease biomarkers - Written for neuroscience researchers and clinicians studying or treating patients with Alzheimer's Disease - Integrates, in each chapter, the molecular/cellular abnormality due to Alzheimer's disease and the technological advancement of biomarkers techniques
