Altered Genes - Omnibus (Books 1,2,3)


Book Description

To save the world, first they have to save themselves… When an unconscious British businessman arrives at New York City’s Bellevue Hospital, Dr. Mei Ling unwittingly finds herself in the midst of an infectious outbreak. Meanwhile, Professor Tony Simmons, her ex-lover, and a world-renowned geneticist at Georgetown University receives an enigmatic telephone call that hints at a genetic threat, unlike anything the world has ever seen. As the pandemic spreads, governments close their borders and quarantine cities. Simmons is taken to a secret military laboratory to search for a cure. But it’s the truth he finds instead, and now he, Ling, and an odd group of survivors are on the run as civilization collapses around them. A superb action-packed thriller based on frighteningly realistic science. Perfect for fans of Michael Crichton, Robin Cook or William R. Forstchen. Get a copy today and immerse yourself in an apocalyptic future you’ll hope won’t ever happen. The Altered Genes Trilogy consists of: Altered Genes : Genesis Altered Genes : Revelations Altered Genes : Resurrection




Altered Genes


Book Description

Includes all three Altered Genes books in one volume. When an unconscious British businessman arrives at New York City's Bellevue Hospital, Dr. Mei Ling unwittingly finds herself in the midst of an infectious outbreak.Meanwhile, Professor Tony Simmons, her ex-lover, and a world-renowned geneticist at Georgetown University receives an enigmatic telephone call that hints at a genetic threat, unlike anything the world has ever seen.As the pandemic spreads, governments close their borders and quarantine cities. Simmons is taken to a secret military laboratory to search for a cure. But it's the truth he finds instead, and now he, Ling, and an odd group of survivors are on the run as civilization collapses around them.A superb action-packed thriller series based on frighteningly realistic science. Perfect for fans of Michael Crichton, Robin Cook or William R. Forstchen.Get a copy today and immerse yourself in an apocalyptic future you'll hope won't ever happen. The Altered Genes Trilogy consists of:Altered Genes : GenesisAltered Genes : RevelationsAltered Genes : Resurrection




Genome-wide view on the physiology of vitamin D


Book Description

The main physiological actions of the biologically most active metabolite of vitamin D, 1a,25-dihydroxyvitamin D3(1a,25(OH)2D3), are calcium and phosphorus uptake and transport and thereby controlling bone formation. Other emergent areas of 1a,25(OH)2D3 action are in the control of immune functions, cellular growth and differentiation. This fits both with the widespread expression of the VDR and the above described consequences of vitamin D deficiency. Transcriptome-wide analysis indicated that per cell type between 200 and 600 genes are primary targets of vitamin D. Since most of these genes respond to vitamin D in a cell-specific fashion, the total number of vitamin D targets in the human genome is far higher than 1,000. This is supported by the genome-wide view on VDR binding sites in human lymphocytes, monocytes, colon and hepatic cells. All genomic actions of 1a,25(OH)2D3 are mediated by the transcription factor vitamin D receptor (VDR) that has been the subject of intense study since the 1980’s. Thus, vitamin D signaling primarily implies the molecular actions of the VDR. In this research topic, we present in 15 chapters different perspectives on the action of vitamin D and its receptor, such as the impact of the genomewide distribution of VDR binding loci, ii) the transcriptome- and proteome-wide effects of vitamin D, iii) the role of vitamin D in health, iv) tissue-specific functions of vitamin D and v) the involvement of vitamin D in different diseases, such as infections, autoimmune diseases, diabetes and different types of cancer.




Altered Genes: Resurrection


Book Description

Revenge Always Comes At a Price... While Professor Tony Simmons continues his efforts to develop a cure for the man-made pathogenic bacteria ravaging the world, Lucia Sanchez returns to the United States seeking vengeance for the death of her children. But revenge is a powerful drug capable of turning old friends into enemies. Will Lucia come to regret the choices she’s made as new threats arise, endangering the people she loves and protects? Read the third and final book in the Altered Genes Trilogy and find out. Perfect for fans of Michael Crichton, Robin Cook or William R. Forstchen. The Altered Genes Trilogy consists of: Altered Genes : Genesis Altered Genes : Revelations Altered Genes : Resurrection




The Silver Age of Comic Book Art


Book Description

Carmine Infantino. Steve Ditko. Jack Kirby. Gil Kane. Joe Kubert. Gene Colan. Jim Steranko. Neal Adams. Some of the greatest comic book artists of their generation, who created some of their greatest work during The Silver Age of Comics (circa1956-1970). They not only drew definitive versions of the medium’s greatest characters including The Flash, Batman, Captain America, Superman, Thor, Green Lantern, Spider-Man, Dr. Strange, Green Arrow and more— but set trends in the art of comic book storytelling. Now this popular and influential body of work, along with each artist’s thoughts, ideas and commentary, is presented in The Silver Age of Comic Book Art, a coffee table comic book art history book written and designed in a daringly different format by comic book historian and illustrator Arlen Schumer, and published in hardcover and digital/e-book editions by Archway Publishing (from Simon & Schuster). Dynamic spreads of the actual printed comic art, graphically enlarged, are integrated with comic-styled text, often by the artists themselves, that replaces the original comic book copy with more personalized prose that places the art firmly in the period it was created: the turbulent 1960s. By creating a comic book history book that reads like a comic book, Schumer succeeds spectacularly in making you see, as if for the first time, the comics you’ve been reading your whole life. “Arlen Schumer documents an important period in comic book history, told with an explosive format and stunning design. It reflects the kinetic rhythm of the era.” — Will Eisner (1917-2005), creator of The Spirit and the graphic novel A Contract with God "Through the years, I’ve had the pleasure of seeing many books that pay tribute to the art of comics, but Arlen Schumer has created an entirely new format in presenting the art and words of the artists. It's the most comprehensive and personal way a fan or colleague can learn what lies beneath the art. Arlen has found the perfect way to inform and entertain. It’s simply awesome —and the best representation of my work ever!” —Gene Colan (1926-2011), legendary comic book artist “A lovingly crafted tribute to the superhero comic of the 1960s, The Silver Age of Comic Book Art recaptures the four-color visionary surge of the era, its jet-age psychedelic rush of imagination and the titanic, luminous figures, both real and imaginary, that glittered in its firmament. For a brief moment in the late 20th century, it seemed as if the spirit of the age wore a vivid leotard, a chest emblem, and traveled in a strobing blur of speed lines. For anyone with any interest in or affection for that moment, this beautiful volume is indispensible.” — Alan Moore, author of Swamp Thing and Watchmen For more on The Silver Age of Comic Book Book Art, join Arlen’s Facebook group of the same name, and visit Arlen’s website: www.arlenschumer.com







Cancer Bioinformatics


Book Description

This book discusses the application of bioinformatics in cancer disease management. It covers general aspects of cancer as a disease but also as a success story in the translation of omics data in clinical settings. It provides an overview of the specific applications of bioinformatics tools in cancer epidemiology, prevention, and screening and in the identification of novel genetic and molecular biomarkers involved in cancer development. This is accomplished through the inclusion of numerous examples of the use of bioinformatics in precision oncology.




Altered Genes : Revelations


Book Description

Friend or Foe…The difference isn’t always obvious. In a world ravaged by a global pandemic, a remote Canadian farm community is the perfect place to hide—or is it? For world-renowned geneticist, Professor Tony Simmons, and the small group of survivors who escaped with him, it might not be. Desperate to find the equipment and resources needed to develop a cure, Simmons is forced to leave the safety of his quiet farm and venture into a world overrun by desperate survivors, roaming gangs of killers, and renegade soldiers. Out amongst the chaos, Simmons finds pockets of civilization and it’s up to him to convince the people living in them to join his efforts to protect the one person who can save them all—because without her, there is no hope, only despair. But will he succeed? Get the second book in the action-packed Altered Genes trilogy and find out. Perfect for fans of Michael Crichton, Robin Cook or William R. Forstchen. The Altered Genes Trilogy consists of: Altered Genes : Genesis Altered Genes : Revelations Altered Genes : Resurrection




Computational Medicine


Book Description

Computational methodologies and modeling play a growing role for investigating mechanisms, and for the diagnosis and therapy of human diseases. This progress gave rise to computational medicine, an interdisciplinary field at the interface of computer science and medicine. The main focus of computational medicine lies in the development of data analysis methods and mathematical modeling as well as computational simulation techniques specifically addressing medical problems. In this book, we present a number of computational medicine topics at several scales: from molecules to cells, organs, and organisms. At the molecular level, tools for the analysis of genome variations as well as cloud computing resources for medical genetics are reviewed. Then, an analysis of gene expression data and the application to the characterization of microbial communities are highlighted. At the protein level, two types of analyses for mass spectrometry data are reviewed: labeled quantitative proteomics and lipidomics, followed by protein sequence analysis and a 3D structure and drug design chapter. Finally, three chapters on clinical applications focus on the integration of biomolecular and clinical data for cancer research, biomarker discovery, and network-based methods for computational diagnostics.