Optimal Experimental Design with R


Book Description

Experimental design is often overlooked in the literature of applied and mathematical statistics: statistics is taught and understood as merely a collection of methods for analyzing data. Consequently, experimenters seldom think about optimal design, including prerequisites such as the necessary sample size needed for a precise answer for an experi




Statistical Power Analysis for the Behavioral Sciences


Book Description

Statistical Power Analysis is a nontechnical guide to power analysis in research planning that provides users of applied statistics with the tools they need for more effective analysis. The Second Edition includes: * a chapter covering power analysis in set correlation and multivariate methods; * a chapter considering effect size, psychometric reliability, and the efficacy of "qualifying" dependent variables and; * expanded power and sample size tables for multiple regression/correlation.




Handbook of Drug Abuse Prevention


Book Description

This wide-ranging handbook brings together experts in the sociology of drug abuse prevention. Providing a comprehensive overview of the accumulated knowledge on prevention theory, intervention design, and development and prevention research methodology, this work also promotes prevention science as an evolving field in the practice and policy of drug abuse prevention.




Practical Statistical Power Analysis


Book Description

The importance of conducting a statistical power analysis at the beginning of a study is universally accepted. Without careful planning, a study can easily fail to detect an existing effect by chance. This book teaches how to conduct power analysis for a range of models from correlation and t-test to structural equation models and multilevel models. Both a graphical Web software WebPower and an R package are introduced to practically conduct the analysis.




Statistical Inference as Severe Testing


Book Description

Mounting failures of replication in social and biological sciences give a new urgency to critically appraising proposed reforms. This book pulls back the cover on disagreements between experts charged with restoring integrity to science. It denies two pervasive views of the role of probability in inference: to assign degrees of belief, and to control error rates in a long run. If statistical consumers are unaware of assumptions behind rival evidence reforms, they can't scrutinize the consequences that affect them (in personalized medicine, psychology, etc.). The book sets sail with a simple tool: if little has been done to rule out flaws in inferring a claim, then it has not passed a severe test. Many methods advocated by data experts do not stand up to severe scrutiny and are in tension with successful strategies for blocking or accounting for cherry picking and selective reporting. Through a series of excursions and exhibits, the philosophy and history of inductive inference come alive. Philosophical tools are put to work to solve problems about science and pseudoscience, induction and falsification.




Statistical Power Analysis


Book Description

This program, companion software to the text "Statistical Power Analysis, Second Edition, " includes the following features: * Spreadsheet Input. Data may be entered by means of a spreadsheet interface. As any cells in the spreadsheet (Mean, SD, N, Alpha, Tails, etc.) are modified by the user, the value of Effect Size and Power are simultaneously updated. * Graphic Input. Alternatively, data may be entered by means of a graphic interface. Cursor keys are used to modify graphs of the group distributions, and the value of power is updated in response. * Active HELP Screens. In addition to providing instructions and explanations, the HELP screens function as worksheets which enable the user to compute various parameters and return these values to the program. * Simulations. The program can run on-screen Monte Carlo simulations, repeatedly drawing samples from a user-defined population and testing each sample for significance. Useful for teaching! * Tables and Graphs. The program creates both tables and graphs of power as a function of N, Effect Size (Mean Difference, Correlation, etc.) and Alpha. Interface with graphics programs generates presentation quality graphics. * Procedures. The program produces power analyses for designs using t-Tests, Correlations, Proportions (Chi- square with or without Yates correction), Oneway and Factorial ANOVA/ANCOVA, and Multiple/Hierarchical regression. The program runs on any IBM or compatible computer; all functions work properly on monochrome as well as on color monitors. A 185-page manual is also available with the software. Please specify disk size (5.25 or 3.5) when ordering.




Sample Size Calculations in Clinical Research


Book Description

Praise for the Second Edition: "... this is a useful, comprehensive compendium of almost every possible sample size formula. The strong organization and carefully defined formulae will aid any researcher designing a study." -Biometrics "This impressive book contains formulae for computing sample size in a wide range of settings. One-sample studies and two-sample comparisons for quantitative, binary, and time-to-event outcomes are covered comprehensively, with separate sample size formulae for testing equality, non-inferiority, and equivalence. Many less familiar topics are also covered ..." – Journal of the Royal Statistical Society Sample Size Calculations in Clinical Research, Third Edition presents statistical procedures for performing sample size calculations during various phases of clinical research and development. A comprehensive and unified presentation of statistical concepts and practical applications, this book includes a well-balanced summary of current and emerging clinical issues, regulatory requirements, and recently developed statistical methodologies for sample size calculation. Features: Compares the relative merits and disadvantages of statistical methods for sample size calculations Explains how the formulae and procedures for sample size calculations can be used in a variety of clinical research and development stages Presents real-world examples from several therapeutic areas, including cardiovascular medicine, the central nervous system, anti-infective medicine, oncology, and women’s health Provides sample size calculations for dose response studies, microarray studies, and Bayesian approaches This new edition is updated throughout, includes many new sections, and five new chapters on emerging topics: two stage seamless adaptive designs, cluster randomized trial design, zero-inflated Poisson distribution, clinical trials with extremely low incidence rates, and clinical trial simulation.




Statistical Power Analysis with Missing Data


Book Description

Statistical power analysis has revolutionized the ways in which we conduct and evaluate research. Similar developments in the statistical analysis of incomplete (missing) data are gaining more widespread applications. This volume brings statistical power and incomplete data together under a common framework, in a way that is readily accessible to those with only an introductory familiarity with structural equation modeling. It answers many practical questions such as: How missing data affects the statistical power in a study How much power is likely with different amounts and types of missing data How to increase the power of a design in the presence of missing data, and How to identify the most powerful design in the presence of missing data. Points of Reflection encourage readers to stop and test their understanding of the material. Try Me sections test one’s ability to apply the material. Troubleshooting Tips help to prevent commonly encountered problems. Exercises reinforce content and Additional Readings provide sources for delving more deeply into selected topics. Numerous examples demonstrate the book’s application to a variety of disciplines. Each issue is accompanied by its potential strengths and shortcomings and examples using a variety of software packages (SAS, SPSS, Stata, LISREL, AMOS, and MPlus). Syntax is provided using a single software program to promote continuity but in each case, parallel syntax using the other packages is presented in appendixes. Routines, data sets, syntax files, and links to student versions of software packages are found at www.psypress.com/davey. The worked examples in Part 2 also provide results from a wider set of estimated models. These tables, and accompanying syntax, can be used to estimate statistical power or required sample size for similar problems under a wide range of conditions. Class-tested at Temple, Virginia Tech, and Miami University of Ohio, this brief text is an ideal supplement for graduate courses in applied statistics, statistics II, intermediate or advanced statistics, experimental design, structural equation modeling, power analysis, and research methods taught in departments of psychology, human development, education, sociology, nursing, social work, gerontology and other social and health sciences. The book’s applied approach will also appeal to researchers in these areas. Sections covering Fundamentals, Applications, and Extensions are designed to take readers from first steps to mastery.




Power Analysis for Experimental Research


Book Description

Power analysis is an essential tool for determining whether a statistically significant result can be expected in a scientific experiment prior to the experiment being performed. Many funding agencies and institutional review boards now require power analyses to be carried out before they will approve experiments, particularly where they involve the use of human subjects. This comprehensive, yet accessible, book provides practising researchers with step-by-step instructions for conducting power/sample size analyses, assuming only basic prior knowledge of summary statistics and the normal distribution. It contains a unified approach to statistical power analysis, with numerous easy-to-use tables to guide the reader without the need for further calculations or statistical expertise. This will be an indispensable text for researchers and graduates in the medical and biological sciences needing to apply power analysis in the design of their experiments.




Doing Meta-Analysis with R


Book Description

Doing Meta-Analysis with R: A Hands-On Guide serves as an accessible introduction on how meta-analyses can be conducted in R. Essential steps for meta-analysis are covered, including calculation and pooling of outcome measures, forest plots, heterogeneity diagnostics, subgroup analyses, meta-regression, methods to control for publication bias, risk of bias assessments and plotting tools. Advanced but highly relevant topics such as network meta-analysis, multi-three-level meta-analyses, Bayesian meta-analysis approaches and SEM meta-analysis are also covered. A companion R package, dmetar, is introduced at the beginning of the guide. It contains data sets and several helper functions for the meta and metafor package used in the guide. The programming and statistical background covered in the book are kept at a non-expert level, making the book widely accessible. Features • Contains two introductory chapters on how to set up an R environment and do basic imports/manipulations of meta-analysis data, including exercises • Describes statistical concepts clearly and concisely before applying them in R • Includes step-by-step guidance through the coding required to perform meta-analyses, and a companion R package for the book