Animal Disorders


Book Description

Animal disorders--those erratic, contradictory, irrational relationships that humans have with their nonhuman compatriots--abound in contemporary U.S. culture. In a series of personal essays, Deborah Thompson relates her own complicity in some of these disordered approaches to nonhuman animals, including such practices as pet-keeping, animal hoarding, animal sacrifice (both religious and scientific), magical thinking, and grieving. The sometimes funny, sometimes poignant essays in this collection deliver dispatches from one representative sufferer of animal disorders.




Animal Models of Neurological Disorders


Book Description

This book introduces undergraduate, postgraduate and research students and scientists to animal models of neurological disorders, along with their working principle and brief procedures. Addressing all the disorders related to the central nervous system (CNS) in a single platform, on the basis of various literature surveys it describes different procedures to induce a single disease with the help of toxins/chemicals. It also includes numerous protocols for inducing single neurological diseases, thus fulfilling an urgent need for a book that makes specific procedures for neurological disorders available, so that specific disease can be induced in laboratories according to the availability of resources. Further, it acquaints readers with the pathological changes that occur in a particular neurological disorder, which reflect specific signs and symptoms of any particular disease, and examines how they affect everyday life. It is a valuable resource for researchers aiming to eradicate or improve neurological disorders by testing the benefits of different drugs.




Animal Models for the Study of Human Disease


Book Description

Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. - Organized by disease orientation for ease of searchability - Provides information on locating resources, animal alternatives and animal ethics - Covers a broad range of animal models used in research for human disease




Improving the Utility and Translation of Animal Models for Nervous System Disorders


Book Description

Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected. Specifically, the workshop objectives were to: discuss key issues that contribute to poor translation of animal models in nervous system disorders, examine case studies that highlight successes and failures in the development and application of animal models, consider strategies to increase the scientific rigor of preclinical efficacy testing, explore the benefits and challenges to developing standardized animal and behavioral models. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional translation between basic and clinical research and determines the next steps that will be critical for improvement of the development and testing of animal models of disorders of the nervous system.




Small Animal Spinal Disorders


Book Description

Updated to keep pace with the cutting edge of technology, the new edition of this essential text has been reorganized and expanded. The broad scope of spinal disorders is covered, along with an abundance of color and black-and-white illustrations. Its well-organized approach begins with chapters on relevant anatomy and clinical examination, proceeding to delve into the most updated diagnosis, differential diagnosis, and pre-operative diagnostic aids, concluding with the review of each spinal disorder. This edition moves from an atlas-style presentation to that of a fully illustrated text. Lengthy figure legends have been replaced with shorter, easier-to-digest figure legends. 50 new color prints and line figures enhance coverage on new spine surgery techniques. A description-rich presentation of surgical procedures, outcomes, and complications makes this edition a vital resource for every clinical practice. This edition moves from an atlas-style presentation to that of a fully illustrated text. Lengthy figure legends have been replaced with shorter, easier-to-digest figure legends. 50 new color prints and line figures enhance coverage on new spine surgery techniques. A description-rich presentation of surgical procedures, outcomes, and complications makes this edition a vital resource for every clinical practice.




Modeling Neuropsychiatric Disorders in Laboratory Animals


Book Description

Modeling Neuropsychiatric Disorders in Laboratory Animals serves as a guide for students and basic investigators in the fields of behavioral sciences, psychology, neuroscience, psychiatry, and other professionals interested in the use of animal models in preclinical research related to human neuropsychiatric disorders. The text focuses on the rationale and theory of using animal behavior, both pathological and normal, as a tool for understanding the neural underpinnings of neuropsychiatric disorders. Chapters contain discussions on both classical and modern views on the validation of animal models for neuropsychiatric disorders, also discussing the utility of endophenotypes in modeling neuropsychiatric disease. Subsequent chapters deal with four specific classes of disorders, including anxiety disorders, depressive disorders, obsessive-compulsive and related disorders. Final sections discuss the future for the development, validation, and use of animal models in basic and preclinical research. - Focuses on the rationale and theory of using animal behavior, both pathological and normal, as a tool for understanding the neural underpinnings of neuropsychiatric disorders - Serves as a guide for students and basic investigators in the fields of behavioral sciences, psychology, neuroscience, psychiatry, and other professionals - Discusses specific classes of disorders, including anxiety disorders, depressive disorders, obsessive-compulsive and related disorders




Large Animal Internal Medicine - E-Book


Book Description

Large Animal Internal Medicine, 4th Edition features a problem-based approach with discussions of over 150 clinical signs. This is the first internal medicine reference that enables you to efficiently diagnose horses, cattle, sheep, and goats based on clinical observation and laboratory and diagnostic testing. With this user-friendly format, you can find essential information about specific diseases and reach a diagnosis by simply identifying the signs. A unique problem-based approach with discussions of over 150 clinical signs and manifestations helps you quickly reach a diagnosis based on observations and laboratory tests. Causes of Presenting Signs boxes provide easy access to complete lists of common, less common, and uncommon diseases associated with manifestations or signs of disease. Complete lists of diseases associated with a given lab abnormality in Causes of Abnormal Laboratory Values boxes help you easily interpret abnormalities in clinical chemistry, hematology, blood proteins, and clotting tests. An expert team of over 180 authors contributing information in their areas of expertise ensures you are using the most accurate and up-to-date information available. Color plates accompanying Diseases of the Eye and Diseases of the Alimentary Tract enable you to visually recognize the clinical appearance of ophthalmologic conditions and alimentary tract disorders for quick and easy diagnosis and treatment. Six all-new chapters provide in-depth coverage of diagnostic testing, critical care and fluid therapy, biosecurity and infection control, and genetic disorders.




Psychopharmacology of Animal Behaviour Disorders


Book Description

Increasingly, veterinarians are called on to treat behavioural disorders in companion pets such as cats, dogs and horses, which can often develop aggressive compulsive or other antisocial habits. In America, veterinarians are beginning to treat these disorders with psychotropic drugs such as Prozac, which have already been shown to yield good results in humans. In the UK, these drugs cannot yet be used on animals, but a number of pharmaceutical companies are developing derivatives for use in animal practice and these products are eagerly awaited. The effects are expected to be as far-reaching as tranquillisers and antidegressants were when they were introduced into human medicine.




Small Animal Clinical Diagnosis by Laboratory Methods


Book Description

A quick guide to appropriately selecting and interpreting laboratory tests, Small Animal Clinical Diagnosis by Laboratory Methods, 5th Edition helps you utilize your in-house lab or your specialty reference lab to efficiently make accurate diagnoses without running a plethora of unnecessary and low-yield tests. It provides answers to commonly asked questions relating to laboratory tests, and solutions to frequently encountered problems in small animal diagnosis. For easy reference, information is provided by clinical presentation and abnormalities, and includes hundreds of tables, boxes, key points, and algorithms. This edition, now in full color, is updated with the latest advances in laboratory testing methods and diagnostic problem solving. Written by noted educators Dr. Michael Willard and Dr. Harold Tvedten, this book may be used as an on-the-spot guide to specific problems or conditions as well as a reference for more detailed research on difficult cases. - Concise discussions address laboratory approaches to various disorders, possible conclusions from various test results, artifacts and errors in diagnoses, and interpretations leading to various diagnoses. - Hundreds of tables, boxes, algorithms, and key points offer at-a-glance information including cautions, common pitfalls, and helpful "pearls," and lead to proper differential and clinical diagnostic decision making. - Note boxes identify key considerations in correlating clinical signs with test data for accurate diagnoses, highlight safety precautions, and offer helpful tips for sample preparation and interpretation. - Chapters on laboratory diagnostic toxicology and therapeutic drug monitoring help in handling potentially fatal poisonings and other special situations. - Expert editors and contributors provide clinical knowledge and successful diagnostic problem-solving solutions. - A practical appendix lists referral laboratories that may be contacted for certain diseases, and reference values with the normal or expected range for coagulation, hematology, and more. - Updated coverage integrates the newest advances in testing methods and diagnostic problem solving. - Full-color photos and schematic drawings are placed adjacent to related text, and accurately depict diagnostic features on microscopic slide preparations as well as test procedures and techniques.




Pathology of Wildlife and Zoo Animals


Book Description

Pathology of Wildlife and Zoo Animals is a comprehensive resource that covers the pathology of wildlife and zoo species, including a wide scope of animals, disease types and geographic regions. It is the definitive book for students, biologists, scientists, physicians, veterinary clinicians and pathologists working with non-domestic species in a variety of settings. General chapters include information on performing necropsies, proper techniques to meet the specialized needs of forensic cases, laboratory diagnostics, and an introduction into basic principles of comparative clinical pathology. The taxon-based chapters provide information about disease in related groups of animals and include descriptions of gross and histologic lesions, pathogenesis and diagnostics. For each group of animals, notable, unique gross and microscopic anatomical features are provided to further assist the reader in deciding whether differences from the domestic animal paradigm are "normal." Additional online content, which includes text, images, and whole scanned glass slides of selected conditions, expands the published material resulting in a comprehensive approach to the topic. - 2019 PROSE Awards - Winner: Category: Textbook/Biological and Life Sciences: Association of American Publishers - Presents a single resource for performing necropsies on a variety of taxa, including terrestrial and aquatic vertebrates and invertebrates - Describes notable, unique gross and microscopic anatomical variations among species/taxa to assist in understanding normal features, in particular those that can be mistaken as being abnormal - Provides consistent organization of chapters with descriptions of unique anatomic features, common non-infectious and infectious diseases following brief overviews of the taxonomic group - Contains full-color, high quality illustrations of diseases - Links to a large online library of scanned slides related to topics in the book that illustrate important histologic findings