Multiphase Flow Phenomena And Applications: Memorial Volume In Honor Of Gad Hetsroni


Book Description

This volume is dedicated to a very special person, Professor Gad Hetsroni (1934-2015). His towering figure was familiar to researchers in heat transfer and multiphase flow all over the world. He was the founding Editor of the International Journal of Multiphase Flow and the person who defined and promoted the discipline around the journal. The unique community formed in this field during his lifetime gathers every three years for a major conference, the International Conference on Multiphase Flow, that most recent was held in May 2016 in Florence, Italy. This was the first time ever Gad did not attend ICMF. Friends and colleagues from many countries came to Florence to present their personal tributes and scientific papers honoring Gad. Reviewed and edited tributes and scientific papers dedicated to Gad from these memorial sessions comprise the core content of this memorial volume; certain persons who could not participate in the ICMF made later contributions.




Chemical Engineering in the Pharmaceutical Industry


Book Description

A guide to the important chemical engineering concepts for the development of new drugs, revised second edition The revised and updated second edition of Chemical Engineering in the Pharmaceutical Industry offers a guide to the experimental and computational methods related to drug product design and development. The second edition has been greatly expanded and covers a range of topics related to formulation design and process development of drug products. The authors review basic analytics for quantitation of drug product quality attributes, such as potency, purity, content uniformity, and dissolution, that are addressed with consideration of the applied statistics, process analytical technology, and process control. The 2nd Edition is divided into two separate books: 1) Active Pharmaceutical Ingredients (API’s) and 2) Drug Product Design, Development and Modeling. The contributors explore technology transfer and scale-up of batch processes that are exemplified experimentally and computationally. Written for engineers working in the field, the book examines in-silico process modeling tools that streamline experimental screening approaches. In addition, the authors discuss the emerging field of continuous drug product manufacturing. This revised second edition: Contains 21 new or revised chapters, including chapters on quality by design, computational approaches for drug product modeling, process design with PAT and process control, engineering challenges and solutions Covers chemistry and engineering activities related to dosage form design, and process development, and scale-up Offers analytical methods and applied statistics that highlight drug product quality attributes as design features Presents updated and new example calculations and associated solutions Includes contributions from leading experts in the field Written for pharmaceutical engineers, chemical engineers, undergraduate and graduation students, and professionals in the field of pharmaceutical sciences and manufacturing, Chemical Engineering in the Pharmaceutical Industry, Second Edition contains information designed to be of use from the engineer's perspective and spans information from solid to semi-solid to lyophilized drug products.




Fundamentals of Dispersed Multiphase Flows


Book Description

Dispersed multiphase flows are frequently found in nature and have diverse geophysical, environmental, industrial, and energy applications. This book targets a beginning graduate student looking to learn about the physical processes that govern these flows, going from the fundamentals to the state of the art, with many exercises included.




Advances in Chemical Engineering


Book Description

Multi-scale analysis and simulation of chemical processing and reactions have received unprecedented attention in recent years; however, measurement technology focused on multi-scale structures, particularly on meso-scale phenomena, has not been sufficiently addressed. This volume of Advances in Chemical Engineering focuses on the "Characterization of Flow, Particles and Interfaces" to alert the chemical engineering community to this challenging issue presenting six meso-scale measurement technologies.




Turbulent Multiphase Flows with Heat and Mass Transfer


Book Description

Numerous industrial systems or natural environments involve multiphase flows with heat and mass transfer. The authors of this book present the physical modeling of these flows, in a unified way, which can include various physical aspects and several levels of complexity. Thermal engineering and nuclear reactors; the extraction and transport of petroleum products; diesel and rocket engines; chemical engineering reactors and fluidized beds; smoke or aerosol dispersion; landslides and avalanches − the modeling of multiphase flows with heat and mass transfer for all these situations can be developed following a common methodology. This book is devoted to the description of the mathematical bases of how to incorporate adequate physical ingredients in agreement with known experimental facts and how to make the model evolve according to the required complexity. Contents Part 1. Approach and General Equations 1. Towards a Unified Description of Multiphase Flows. 2. Instant Equations for a Piecewise Continuous Medium. 3. Description of a “Mean Multiphase Medium”. 4. Equations for the Mean Continuous Medium. Part 2. Modeling: A Single Approach Adaptable to Multiple Applications 5. The Modeling of Interphase Exchanges. 6. Modeling Turbulent Dispersion Fluxes. 7. Modeling the Mean Gas–Liquid Interface Area per Unit Volume. 8. “Large Eddy Simulation” Style Models. 9. Contribution of Thermodynamics of Irreversible Processes. 10. Experimental Methods. 11. Some Experimental Results Pertaining to Multiphase Flow Properties that Are Still Little Understood. Part 3. From Fluidized Beds to Granular Media 12. Fluidized Beds. 13. Generalizations for Granular Media. 14. Modeling of Cauchy Tensor of Sliding Contacts. 15. Modeling the Kinetic Cauchy Stress Tensor. Part 4. Studying Fluctuations and Probability Densities 16. Fluctuations of the Gas Phase in Reactive Two-Phase Media. 17. Temperature Fluctuations in Condensed Phases. 18. Study of the PDF for Velocity Fluctuations and Sizes of Parcels. About the Authors Roland Borghi is Professor Emeritus at Ecole Centrale Marseille in France and works as a consultant in the space, petrol and automobile sectors. His research activities cover fluid mechanics, combustion and flames, and multi-phase and granular flows. He was a member of the CNRS scientific committee and a laureate of the French Academy of Science. Fabien Anselmet is Professor at Ecole Centrale Marseille in France. His research activities focus on the turbulence of fluids and its varied applications in industry and in fields linked to the environment. With a unified, didactic style, this text presents tangible models of multiphase flows with heat and mass transfer with attention to various levels of complexities. It addresses thermal engineering and nuclear reactors, extraction and transport of petroleum products, diesel engines and rocket engines, chemical engineering reactors and fluidized beds, smoke or aerosol dispersion, and landslides and avalanches. Engineers, researchers, and scientists will appreciate the discussions of modeling principles, flows and granular media, and fluctuations around averages.










Computational Methods in Multiphase Flow V


Book Description

Together with turbulence, multiphase flow remains one of the most challenging areas of computational mechanics and experimental methods and numerous problems remain unsolved to date. Multiphase flows are found in all areas of technology, at all length scales and flow regimes. The fluids involved can be compressible or incompressible, linear or nonlinear. Because of the complexity of the problems, it is often essential to utilize advanced computational and experimental methods to solve the complex equations that describe them. Challenges in these simulations include modelling and tracking interfaces, dealing with multiple length scales, modelling nonlinear fluids, treating drop breakup and coalescence, characterizing phase structures, and many others. Experimental techniques, although expensive and difficult to perform, are essential to validate models. This book contains papers presented at the Fifth International Conference on Computational Methods in Multiphase Flow, which are grouped into the following topics: Multiphase Flow Simulation; Interaction of Gas, Liquids and Solids; Turbulent Flow; Environmental Multiphase Flow; Bubble and Drop Dynamics; Flow in Porous Media; Heat Transfer; Image Processing; Interfacial Behaviour.




Multiphase Particulate Systems in Turbulent Flows


Book Description

Multiphase Particulate Systems in Turbulent Flows: Fluid-Liquid and Solid-Liquid Dispersions provides methods necessary to analyze complex particulate systems and related phenomena including physical, chemical and mathematical description of fundamental processes influencing crystal size and shape, suspension rheology, interfacial area of drops and bubbles in extractors and bubble columns. Examples of mathematical model formulation for different processes taking place in such systems is shown. Discussing connections between turbulent mixing mechanisms and precipitation, it discusses influence of fine-scale structure of turbulence, including its intermittent character, on breakage of drops, bubbles, cells, plant cell aggregates. An important aspect of the mathematical modeling presented in the book is multi-fractal, taking into account the influence of internal intermittency on different phenomena. Key Features Provides detailed descriptions of dispersion processes in turbulent flow, interactions between dispersed entities, and continuous phase in a single volume Includes simulation models and validation experiments for liquid-liquid, gas-liquid, and solid-liquid dispersions in turbulent flows Helps reader learn formulation of mathematical models of breakage or aggregation processes using multifractal theory Explains how to solve different forms of population balance equations Presents a combination of theoretical and engineering approaches to particulate systems along with discussion of related diversity, with exercises and case studies




Handbook of Fluid Dynamics


Book Description

Handbook of Fluid Dynamics offers balanced coverage of the three traditional areas of fluid dynamics—theoretical, computational, and experimental—complete with valuable appendices presenting the mathematics of fluid dynamics, tables of dimensionless numbers, and tables of the properties of gases and vapors. Each chapter introduces a different fluid dynamics topic, discusses the pertinent issues, outlines proven techniques for addressing those issues, and supplies useful references for further research. Covering all major aspects of classical and modern fluid dynamics, this fully updated Second Edition: Reflects the latest fluid dynamics research and engineering applications Includes new sections on emerging fields, most notably micro- and nanofluidics Surveys the range of numerical and computational methods used in fluid dynamics analysis and design Expands the scope of a number of contemporary topics by incorporating new experimental methods, more numerical approaches, and additional areas for the application of fluid dynamics Handbook of Fluid Dynamics, Second Edition provides an indispensable resource for professionals entering the field of fluid dynamics. The book also enables experts specialized in areas outside fluid dynamics to become familiar with the field.