Applied Mixed Model Analysis


Book Description

Emphasizing interpretation of results, this hands-on guide explains why, when, and how to use mixed models with your data.




Applied Mixed Models in Medicine


Book Description

A fully updated edition of this key text on mixed models, focusing on applications in medical research The application of mixed models is an increasingly popular way of analysing medical data, particularly in the pharmaceutical industry. A mixed model allows the incorporation of both fixed and random variables within a statistical analysis, enabling efficient inferences and more information to be gained from the data. There have been many recent advances in mixed modelling, particularly regarding the software and applications. This third edition of Brown and Prescott’s groundbreaking text provides an update on the latest developments, and includes guidance on the use of current SAS techniques across a wide range of applications. Presents an overview of the theory and applications of mixed models in medical research, including the latest developments and new sections on incomplete block designs and the analysis of bilateral data. Easily accessible to practitioners in any area where mixed models are used, including medical statisticians and economists. Includes numerous examples using real data from medical and health research, and epidemiology, illustrated with SAS code and output. Features the new version of SAS, including new graphics for model diagnostics and the procedure PROC MCMC. Supported by a website featuring computer code, data sets, and further material. This third edition will appeal to applied statisticians working in medical research and the pharmaceutical industry, as well as teachers and students of statistics courses in mixed models. The book will also be of great value to a broad range of scientists, particularly those working in the medical and pharmaceutical areas.




Mixed Models


Book Description

Praise for the First Edition “This book will serve to greatly complement the growing number of texts dealing with mixed models, and I highly recommend including it in one’s personal library.” —Journal of the American Statistical Association Mixed modeling is a crucial area of statistics, enabling the analysis of clustered and longitudinal data. Mixed Models: Theory and Applications with R, Second Edition fills a gap in existing literature between mathematical and applied statistical books by presenting a powerful examination of mixed model theory and application with special attention given to the implementation in R. The new edition provides in-depth mathematical coverage of mixed models’ statistical properties and numerical algorithms, as well as nontraditional applications, such as regrowth curves, shapes, and images. The book features the latest topics in statistics including modeling of complex clustered or longitudinal data, modeling data with multiple sources of variation, modeling biological variety and heterogeneity, Healthy Akaike Information Criterion (HAIC), parameter multidimensionality, and statistics of image processing. Mixed Models: Theory and Applications with R, Second Edition features unique applications of mixed model methodology, as well as: Comprehensive theoretical discussions illustrated by examples and figures Over 300 exercises, end-of-section problems, updated data sets, and R subroutines Problems and extended projects requiring simulations in R intended to reinforce material Summaries of major results and general points of discussion at the end of each chapter Open problems in mixed modeling methodology, which can be used as the basis for research or PhD dissertations Ideal for graduate-level courses in mixed statistical modeling, the book is also an excellent reference for professionals in a range of fields, including cancer research, computer science, and engineering.




Linear Mixed Models


Book Description

Simplifying the often confusing array of software programs for fitting linear mixed models (LMMs), Linear Mixed Models: A Practical Guide Using Statistical Software provides a basic introduction to primary concepts, notation, software implementation, model interpretation, and visualization of clustered and longitudinal data. This easy-to-nav




Mixed-Effects Models in S and S-PLUS


Book Description

R, linear models, random, fixed, data, analysis, fit.




Applied Mixed Models in Medicine


Book Description

A fully updated edition of this key text on mixed models, focusing on applications in medical research The application of mixed models is an increasingly popular way of analysing medical data, particularly in the pharmaceutical industry. A mixed model allows the incorporation of both fixed and random variables within a statistical analysis, enabling efficient inferences and more information to be gained from the data. There have been many recent advances in mixed modelling, particularly regarding the software and applications. This third edition of Brown and Prescott’s groundbreaking text provides an update on the latest developments, and includes guidance on the use of current SAS techniques across a wide range of applications. Presents an overview of the theory and applications of mixed models in medical research, including the latest developments and new sections on incomplete block designs and the analysis of bilateral data. Easily accessible to practitioners in any area where mixed models are used, including medical statisticians and economists. Includes numerous examples using real data from medical and health research, and epidemiology, illustrated with SAS code and output. Features the new version of SAS, including new graphics for model diagnostics and the procedure PROC MCMC. Supported by a website featuring computer code, data sets, and further material. This third edition will appeal to applied statisticians working in medical research and the pharmaceutical industry, as well as teachers and students of statistics courses in mixed models. The book will also be of great value to a broad range of scientists, particularly those working in the medical and pharmaceutical areas.




Linear Mixed Models for Longitudinal Data


Book Description

This book provides a comprehensive treatment of linear mixed models for continuous longitudinal data. Next to model formulation, this edition puts major emphasis on exploratory data analysis for all aspects of the model, such as the marginal model, subject-specific profiles, and residual covariance structure. Further, model diagnostics and missing data receive extensive treatment. Sensitivity analysis for incomplete data is given a prominent place. Most analyses were done with the MIXED procedure of the SAS software package, but the data analyses are presented in a software-independent fashion.




Robust Mixed Model Analysis


Book Description

Mixed-effects models have found broad applications in various fields. As a result, the interest in learning and using these models is rapidly growing. On the other hand, some of these models, such as the linear mixed models and generalized linear mixed models, are highly parametric, involving distributional assumptions that may not be satisfied in real-life problems. Therefore, it is important, from a practical standpoint, that the methods of inference about these models are robust to violation of model assumptions. Fortunately, there is a full scale of methods currently available that are robust in certain aspects. Learning about these methods is essential for the practice of mixed-effects models.This research monograph provides a comprehensive account of methods of mixed model analysis that are robust in various aspects, such as to violation of model assumptions, or to outliers. It is suitable as a reference book for a practitioner who uses the mixed-effects models, and a researcher who studies these models. It can also be treated as a graduate text for a course on mixed-effects models and their applications.




Generalized Linear Mixed Models


Book Description

With numerous examples using SAS PROC GLIMMIX, this text presents an introduction to linear modeling using the generalized linear mixed model as an overarching conceptual framework. For readers new to linear models, the book helps them see the big picture. It shows how linear models fit with the rest of the core statistics curriculum and points out the major issues that statistical modelers must consider.




Linear Mixed-Effects Models Using R


Book Description

Linear mixed-effects models (LMMs) are an important class of statistical models that can be used to analyze correlated data. Such data are encountered in a variety of fields including biostatistics, public health, psychometrics, educational measurement, and sociology. This book aims to support a wide range of uses for the models by applied researchers in those and other fields by providing state-of-the-art descriptions of the implementation of LMMs in R. To help readers to get familiar with the features of the models and the details of carrying them out in R, the book includes a review of the most important theoretical concepts of the models. The presentation connects theory, software and applications. It is built up incrementally, starting with a summary of the concepts underlying simpler classes of linear models like the classical regression model, and carrying them forward to LMMs. A similar step-by-step approach is used to describe the R tools for LMMs. All the classes of linear models presented in the book are illustrated using real-life data. The book also introduces several novel R tools for LMMs, including new class of variance-covariance structure for random-effects, methods for influence diagnostics and for power calculations. They are included into an R package that should assist the readers in applying these and other methods presented in this text.