Atherothrombosis and Coronary Artery Disease


Book Description

Written by the world’s foremost authorities, this volume provides comprehensive coverage of current approaches to the prevention, diagnosis, and management of atherothrombosis and its coronary and noncoronary complications. This edition has been thoroughly updated, sharply focused on clinical information, and trimmed to one manageable volume. Coverage begins with a review of risk factors and prevention, emphasizing lipid abnormalities, hypertension, smoking, diabetes, and obesity. Subsequent sections examine the pathogenesis of atherosclerosis, markers and imaging, acute coronary syndromes, chronic stable angina, and noncoronary atherothrombosis. Clinical presentations, medical management, and the latest interventional strategies are included.




Atlas of Atherosclerosis


Book Description

We are in the early years of a new millen Tremendous interest is now focused on nium and atherosclerotic disease is now the characteristics of atherosclerotic thought to underlie more adult deaths plaques, as we recognize that many clinical than any other disease on the planet. The coronary events are attributable to unstable lifetime burden of risk is high, and lesions that do not cause severe stenoses but Framingham data suggest that approxi are prone to rupture and precipitate angina mately 50% of men and 30% of women pectoris or a myocardial infarction. A vari will experience coronary heart disease ety of factors are under study to help deter during their lifetime. This process begins mine what affects the balance between at a young age, and autopsies of casualties plaque stability and instability. Some of this from the Korean and Vietnam wars as well research is fueled by the fact that therapy for as accident victims in more recent times dyslipidemia often has effects that are not have shown that fatty streak lesions are related to the lipoprotein cholesterol alter very common in young adults. Recent ations, but stem from the pleiotropic effects research has extended these pathologic of such medications on hematologic and studies to investigate the dynamics and inflammatory mechanisms. milieu that foster the creation of these The current volume focuses on the early lesions.




Atlas of Atherosclerosis and Metabolic Syndrome


Book Description

This new edition is an integral source of information on Atherosclerosis. It covers topics such as newer coronary risk factors, high-density lipoprotein metabolism, lipid-lowering drugs, endothelium and thrombosis in atherogenesis, and contributing risk factors. With over 500 exceptional photographs, diagrams, and charts, each chapter illustrates an important facet of diagnosing and treating this common and often fatal disease.




Atlas of Atherosclerosis Progression and Regression


Book Description

Completely revised and updated, the Second Edition of the Atlas of Atherosclerosis Progression and Regression contains new material and new illustrations from Dr. Stary's groundbreaking work in the field of atherosclerosis diagnosis, prevention, and treatment. Over 100 photographs show arterial and lesion structure and individual components in unprecedented detail. These images allow you to compare and contrast healthy arteries with those developing and regressing lesions. They illustrate the successive steps in the natural history of human atherosclerotic disease from the microscopically visible, lipid-filled macrophages in susceptible locations of arteries to lesion forms that produce clinical symptoms. The book provides an up-to-date, pathology-based framework of morphologies of atherosclerotic vascular lesions that serves as a basis for correlation with morphologies determined by a variety of clinical imaging techniques. Demonstrating the evolution of arterial lesions form the clinically silent to the clinically relevant, An Atlas of Atherosclerosis Progression and Regression is a teaching aid and diagnostic tool for recognizing changes in lesion progression, stabilization, or regression. About the author: Dr. Stary is Professor of Pathology at the Louisiana State University Health Sciences Center in New Orleans. He came to New Orleans via the Departments of Pathology of the McGill (Montreal) and Yale (New Haven) Medical Schools. For 7 years, Dr. Stary also served as chairman of the American Heart Association's Committee on Vascular Lesions.




Basic Sciences for MCEM


Book Description

This book is a dedicated resource for those sitting the Part A of the MCEM (Membership of the College of Emergency Medicine) examination. It forms an essential revision guide for emergency trainees who need to acquire a broad understanding of the basic sciences, which underpin their approach to clinical problems in the emergency department. Common clinical scenarios are used to highlight the essential underlying basic science principles, providing a link between clinical management and a knowledge of the underlying anatomical, physiological, pathological and biochemical processes. Multiple choice questions with reasoned answers are used to confirm the candidates understanding and for self testing. Unlike other recent revision books which provide MCQ questions with extended answers, this book uses clinical cases linked to the most recent basic science aspects of the CEM syllabus to provide a book that not only serves as a useful revision resource for the Part A component of the MCEM examination, but also a unique way of understanding the processes underlying common clinical cases seen every day in the emergency department. This book is essential for trainees sitting the Part A of the MCEM exam and for clinicians and medical students who need to refresh their knowledge of basic sciences relevant to the management of clinical emergencies.




Handbook of the Vulnerable Plaque


Book Description

Since publication of the First Edition, advances in the diagnosis and prevention and treatment strategies of the vulnerable plaque have necessitated this greatly expanded second edition. With several new chapters covering mainly diagnostic and treatment options, The Handbook of the Vulnerable Plaque will remain the benchmark text for all interventi




Biomechanics of Coronary Atherosclerotic Plaque


Book Description

Biomechanics of Coronary Atherosclerotic Plaque: From Model to Patient, First Edition, is the first comprehensive text to focus on important biomechanical studies conducted in the last decade that have increased our understanding of coronary atherosclerotic plaque initiation, growth, and rupture, as well as improving the design of medical devices and clinical interventions, including surgical procedures. The book provides students, researchers, engineers, clinicians, and interventional cardiologists with an overview of the main topics related to the biomechanics of atherosclerosis, in a single volume written by several experts in the field. This volume is part of the Biomechanics of Living Organs book series. The biomechanics of human soft tissues and organs has been an emerging research field since the publication of Y.C. Fung's original book series in the 1990s. The publication of such books entirely dedicated to a specific biomechanical subject is necessary to advance scientific research in the field of biomechanics and to transfer important knowledge to future generations. Therefore, this series of volumes on the biomechanics of living organs has been created. This series began in July 2017 with the publication of a first volume on the fundamentals of Hyperelastic Constitutive Laws for Finite Element Modeling of Living Organs. The current volume on the Biomechanics of Coronary Atherosclerotic Plaque, is the latest in this new series. - Presents the main computational fluid dynamic studies performed, describing blood flow in healthy and pathological artery branches, including in coronary bifurcations - Highlights the correlation between plaque initiation regions and blood shear stress amplitude - Discusses the main biomechanical and mechanobiological models to highlight the importance of quantifying the residual and peak cap stresses and the presence of μ-calcifications to evaluate the risk of plaque rupture - Introduces the most recent intravascular imaging biomarker techniques (elastography, palpography and modulography)




Collagen


Book Description

Not only does this book provide a comprehensive review of current research advances in collagen structure and mechanics, it also explores this biological macromolecule’s many applications in biomaterials and tissue engineering. Readers gain an understanding of the structure and mechanical behavior of type I collagen and collagen-based tissues in vertebrates across all length scales, from the molecular (nano) to the organ (macro) level.




Outlive


Book Description

#1 NEW YORK TIMES BESTSELLER • OVER ONE MILLION COPIES SOLD • A groundbreaking manifesto on living better and longer that challenges the conventional medical thinking on aging and reveals a new approach to preventing chronic disease and extending long-term health, from a visionary physician and leading longevity expert “One of the most important books you’ll ever read.”—Steven D. Levitt, New York Times bestselling author of Freakonomics AN ECONOMIST AND BLOOMBERG BEST BOOK OF THE YEAR Wouldn’t you like to live longer? And better? In this operating manual for longevity, Dr. Peter Attia draws on the latest science to deliver innovative nutritional interventions, techniques for optimizing exercise and sleep, and tools for addressing emotional and mental health. For all its successes, mainstream medicine has failed to make much progress against the diseases of aging that kill most people: heart disease, cancer, Alzheimer’s disease, and type 2 diabetes. Too often, it intervenes with treatments too late to help, prolonging lifespan at the expense of healthspan, or quality of life. Dr. Attia believes we must replace this outdated framework with a personalized, proactive strategy for longevity, one where we take action now, rather than waiting. This is not “biohacking,” it’s science: a well-founded strategic and tactical approach to extending lifespan while also improving our physical, cognitive, and emotional health. Dr. Attia’s aim is less to tell you what to do and more to help you learn how to think about long-term health, in order to create the best plan for you as an individual. In Outlive, readers will discover: • Why the cholesterol test at your annual physical doesn’t tell you enough about your actual risk of dying from a heart attack. • That you may already suffer from an extremely common yet underdiagnosed liver condition that could be a precursor to the chronic diseases of aging. • Why exercise is the most potent pro-longevity “drug”—and how to begin training for the “Centenarian Decathlon.” • Why you should forget about diets, and focus instead on nutritional biochemistry, using technology and data to personalize your eating pattern. • Why striving for physical health and longevity, but ignoring emotional health, could be the ultimate curse of all. Aging and longevity are far more malleable than we think; our fate is not set in stone. With the right roadmap, you can plot a different path for your life, one that lets you outlive your genes to make each decade better than the one before.