Beryllium Poisoning


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The Toxicology of Beryllium


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Managing Health Effects of Beryllium Exposure


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Beryllium is a lightweight metal that is used for its exceptional strength and high heat-absorbing capability. Beryllium and its alloys can be found in many important technologies in the defense and aeronautics industries, such as nuclear devices, satellite systems, radar systems, and aircraft bushings and bearings. Pulmonary disease associated with exposure to beryllium has been recognized and studied since the early 1940s, and an occupational guideline for limiting exposure to beryllium has been in place since 1949. Over the last few decades, much has been learned about chronic beryllium disease and factors that contribute to its occurrence in exposed people. Despite reduced workplace exposure, chronic beryllium disease continues to occur. Those developments have led to debates about the adequacy of the long-standing occupational exposure limit for protecting worker health. This book, requested by the U.S. Air Force to help to determine the steps necessary to protect its workforce from the effects of beryllium used in military aerospace applications, reviews the scientific literature on beryllium and outlines an exposure and disease management program for its protecting workers.







Occupational Exposure to Beryllium


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Beryllium and Beryllium Compounds


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In this volume are assessed the risks to human health and the environment of Beryllium, found in the earth's crust at an average concentration of approximately 2.8-5.0 mg/kg. Beryllium-containing minerals are processed to beryllium metal, beryllium alloys, and beryllium oxide for use in aerospace, weapons, nuclear and electronics industries. The general population is exposed to beryllium primarily in food and drinking-water, with smaller contributions from air and incidental ingestion of dust. There are no human studies addressing the toxicokinetics of beryllium or beryllium compounds; however, beryllium has been found in the lungs and urine of non-occupationally exposed individuals. There are no reliable data on the oral toxicity of beryllium in humans. The lungs are the primary target of inhalation exposure to beryllium in animals and humans. Short-term or repeated exposures of humans to beryllium or its compounds can result in an acute or chronic form of lung disease. Increases in lung cancer mortality were observed in cohort mortality studies of beryllium processing workers.