Beta 2-agonists in Asthma Treatment


Book Description

This authoritative, timely resource analyzes every important topic related to the most frequently prescribed anti-asthma medications-comprehensively examining the use of beta2-agonists from molecular interactions with the beta-receptor to clinical and therapeutic applications in acute and chronic conditions. Includes lively discussion sections that address controversies involving the use of beta2-agonists and synthesizes current information into practical treatment guidelines! Written by world-renowned experts representing prestigious institutions in 12 countries, Beta2-Agonists in Asthma Treatment summarizes the history of beta-agonists in asthma treatment explains the molecular action and effect of beta2-agonists on airway effector cells and inflammation discusses in detail beta2-agonist pharmacokinetics reviews inhalation devices and techniques compares the pharmacological characteristics of long-acting versus short-acting beta2-agonists addresses the possible influence of beta2-agonists in the deterioration of asthmatic conditions and increased mortality delineates the role of beta2-agonists in treating acute and chronic asthma in both children and adults and much more!




Hepatotoxicity


Book Description

Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.




Treatment of Asthma: The long-acting beta-2-agonists


Book Description

The long-acting beta-2-agonists have become indispensible in modern asthma therapy. But do they have a fixed position in international guidelines? Here are the proceedings of the 6th Vienna Asthma Forum, when molecular biologists, drug designers, and clinicians discussed the role of three compounds (bambuterol, formoterol, and salmeterol) on a high scientific level. The authors give a fascinating new insight into the physiology of the Beta2- and glucocorticoid receptor, into the considerations before and during drug development, stimulating a vivid discussion among clinical researchers who share a special interest in the most efficacious use of a new therapeutic principle. The original papers and the individual discussions are highly informative and delightful to read.




Critical Heart Disease in Infants and Children E-Book


Book Description

Features comprehensive updates throughout the text, including indications, techniques, potential complications in perioperative management of patients, and surgical techniques for congenital heart disease. Covers recent advances in the treatment of pulmonary hypertension, developments in mechanical assist devices, heart and lung transplantation, and interventional cardiac catheterization. Features an all-new, full-color format that speeds navigation and helps clarify complex concepts. Contains 27 new chapters with an emphasis on the team approach to patient care in the ICU including creating multidisciplinary teams, quality and performance improvement, training , and challenges and solutions to developing a cohesive team environment. Includes a detailed chapter on bedside ultrasound, walking you through the techniques you’re most likely to encounter in the ICU. Employs well-documented tables, text boxes, and algorithms to make clinical information easy to access, and to provide a more complete understanding of echocardiography, imaging modalities, pulmonary hypertension, and more. Describes the basic pharmacology and clinical applications of new pharmacologic agents. Examines issues affecting adults with congenital heart disease.




Anesthetic Pharmacology


Book Description

In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.




Severe Asthma


Book Description

Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma – epidemiology, diagnosis, mechanisms, treatment and management – but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various ‘omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.




Encyclopedia of Inflammatory Diseases


Book Description

Inflammation has become one of the most exciting and rewarding areas of medical research. Recent years have seen a revolution in our understanding of how blood and tissue cells interact and of the intracellular mechanisms controlling their activation. This has revealed the underlying inflammatory pathology of many diseases and provided multiple new targets for anti-inflammatory and immunomodulatory therapy. The Encyclopedia of Inflammatory Diseases will cover the following areas: Inflammatory Processes and Cells Inflammatory Diseases Mediators of Inflammation Pharmacology of Inflammation Since inflammatory diseases and their therapy cover a broad range of scientific and medical fields, the encyclopedia will be co-edited by four international experts, a clinician and three researchers from the disciplines of immunology, biochemistry, and pharmacology, in this way providing students, basic and clinical scientists and practitioners in academia, hospitals and industry with valuable interlinked information. This living project will serve as a reliable and comprehensive data pool for everybody working in inflammation research. Owing to its dynamic nature, it will grow with time and future editions, becoming an indispensible source of information for academia, clinical practitioners and industry.




Asthma and COPD


Book Description

The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments. * Each chapter considers Asthma and COPD in side-by-side contrast and comparison – not in isolation - in the context of mechanism, triggers, assessments, therapies, and clinical management * Presents the latest and most comprehensive understandings of the mechanisms of inflammation in both Asthma and COPD * Most extensive reference to primary literature on both Asthma and COPD in one source. * Easy-to-read summaries of the latest advances alongside clear illustrations




The Role of Beta Receptor Agonist Therapy in Asthma Mortality


Book Description

First published in 1993, the Role of Beta Receptor Agonist Therapy in Asthma Mortality provides the first comprehensive review of the role of beta-receptor agonist drug therapy and asthma mortality. The book includes sections on the epidemiological and experimental methods used to examine possible relationships between beta-agonist drug therapy and asthma mortality. It also reviews the development of beta-agonist drugs and the long-term trends in asthma mortality to present a historical perspective. Internationally respected experts have contributed to this unique volume, making it essential for epidemiologists, pharmacologists, and researchers in clinical medicine and public health.




Allergy and Asthma


Book Description

Allergy and Asthma: The Basics to Best Practices is intended to serve as a single comprehensive reference covering all needed knowledge of allergic diseases. Allergy is a unique and distinctive area of medicine wherein learning the fundamentals requires gathering information from various different disciplines. Allergic diseases affect various organ systems and the practice of a wide range of physicians from otolaryngologists, and pulmonologists, to gastroenterologists, dermatologists, and ophthalmologists. Clinicians and trainees alike will benefit from a resource that introduces the basic concepts, as well as providing comprehensive, consistently up-to-date instruction on intermediate and advanced conditions, research, and treatment strategies. The book is divided into nine sections and is written by some of the foremost experts in the field. Allergy and Asthma opens with an introduction which covers the epidemiology of allergic diseases, fundamentals of allergy and immunology, and a thorough grounding of different types of allergens. Early sections address allergic upper airway diseases, allergic skin diseases, and asthma in detail, using a structured, consistent format from chapter to chapter to provide continuity and ease of reference. Later sections thoroughly cover various food allergies, insect allergies, drug allergy, anaphylaxis, and utilize ample tables and illustrations to provide additional learning tools for the reader. This major reference not only provides basic knowledge on diagnosing and treating allergies, but moves beyond these basics to emphasize using a systematic approach to working up and treating a patient. A variety of techniques used in diagnosing asthma and allergy will be examined, of which include prick skin tests, in-vitro testing, patch testing and non-conventional allergy tests. Concluding this book are sections dedicated to management, therapeutic strategies of allergy and asthma, with a look to future research directions for this unique field. Physicians and residents in allergy and immunology, pulmonology, otolaryngology, gastroenterology, dermatology, ophthalmology and other specialties will find the work of value in enhancing their practice and studies. Researchers in a range of areas especially immunology and food science will also find this text to be a compelling and reliable resource.