Author : Peter N. Robinson
Publisher : CRC Press
Page : 514 pages
File Size : 41,14 MB
Release : 2011-06-22
Category : Computers
ISBN : 1439836663
Introduction to Bio-Ontologies explores the computational background of ontologies. Emphasizing computational and algorithmic issues surrounding bio-ontologies, this self-contained text helps readers understand ontological algorithms and their applications.The first part of the book defines ontology and bio-ontologies. It also explains the importan
Author : Peter N. Robinson
Publisher : CRC Press
Page : 517 pages
File Size : 27,23 MB
Release : 2020-09-30
Category :
ISBN : 9780367659271
Introduction to Bio-Ontologies explores the computational background of ontologies. Emphasizing computational and algorithmic issues surrounding bio-ontologies, this self-contained text helps readers understand ontological algorithms and their applications. The first part of the book defines ontology and bio-ontologies. It also explains the importance of mathematical logic for understanding concepts of inference in bio-ontologies, discusses the probability and statistics topics necessary for understanding ontology algorithms, and describes ontology languages, including OBO (the preeminent language for bio-ontologies), RDF, RDFS, and OWL. The second part covers significant bio-ontologies and their applications. The book presents the Gene Ontology; upper-level ontologies, such as the Basic Formal Ontology and the Relation Ontology; and current bio-ontologies, including several anatomy ontologies, Chemical Entities of Biological Interest, Sequence Ontology, Mammalian Phenotype Ontology, and Human Phenotype Ontology. The third part of the text introduces the major graph-based algorithms for bio-ontologies. The authors discuss how these algorithms are used in overrepresentation analysis, model-based procedures, semantic similarity analysis, and Bayesian networks for molecular biology and biomedical applications. With a focus on computational reasoning topics, the final part describes the ontology languages of the Semantic Web and their applications for inference. It covers the formal semantics of RDF and RDFS, OWL inference rules, a key inference algorithm, the SPARQL query language, and the state of the art for querying OWL ontologies. Web Resource Software and data designed to complement material in the text are available on the book's website: http: //bio-ontologies-book.org The site provides the R Robo package developed for the book, along with a compressed archive of data and ontology files used in some of the exercises. It also offers teaching/presentation slides and links to other relevant websites. This book provides readers with the foundation to use ontologies as a starting point for new bioinformatics research projects or to support current molecular genetics research projects. By supplying a self-contained introduction to OBO ontologies and the Semantic Web, it bridges the gap between both fields and helps readers see what each can contribute to the analysis and understanding of biomedical data.
Author : Christopher J. O. Baker
Publisher : Springer Science & Business Media
Page : 449 pages
File Size : 13,85 MB
Release : 2007-04-14
Category : Science
ISBN : 0387484388
This book introduces advanced semantic web technologies, illustrating their utility and highlighting their implementation in biological, medical, and clinical scenarios. It covers topics ranging from database, ontology, and visualization to semantic web services and workflows. The volume also details the factors impacting on the establishment of the semantic web in life science and the legal challenges that will impact on its proliferation.
Author : Christophe Dessimoz
Publisher :
Page : 298 pages
File Size : 19,69 MB
Release : 2020-10-08
Category : Science
ISBN : 9781013267710
This book provides a practical and self-contained overview of the Gene Ontology (GO), the leading project to organize biological knowledge on genes and their products across genomic resources. Written for biologists and bioinformaticians, it covers the state-of-the-art of how GO annotations are made, how they are evaluated, and what sort of analyses can and cannot be done with the GO. In the spirit of the Methods in Molecular Biology book series, there is an emphasis throughout the chapters on providing practical guidance and troubleshooting advice. Authoritative and accessible, The Gene Ontology Handbook serves non-experts as well as seasoned GO users as a thorough guide to this powerful knowledge system. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.
Author : Sabina Leonelli
Publisher : University of Chicago Press
Page : 282 pages
File Size : 30,93 MB
Release : 2016-11-18
Category : Science
ISBN : 022641650X
In recent decades, there has been a major shift in the way researchers process and understand scientific data. Digital access to data has revolutionized ways of doing science in the biological and biomedical fields, leading to a data-intensive approach to research that uses innovative methods to produce, store, distribute, and interpret huge amounts of data. In Data-Centric Biology, Sabina Leonelli probes the implications of these advancements and confronts the questions they pose. Are we witnessing the rise of an entirely new scientific epistemology? If so, how does that alter the way we study and understand life—including ourselves? Leonelli is the first scholar to use a study of contemporary data-intensive science to provide a philosophical analysis of the epistemology of data. In analyzing the rise, internal dynamics, and potential impact of data-centric biology, she draws on scholarship across diverse fields of science and the humanities—as well as her own original empirical material—to pinpoint the conditions under which digitally available data can further our understanding of life. Bridging the divide between historians, sociologists, and philosophers of science, Data-Centric Biology offers a nuanced account of an issue that is of fundamental importance to our understanding of contemporary scientific practices.
Author : Nikola Kasabov
Publisher : Springer Science & Business Media
Page : 1239 pages
File Size : 10,86 MB
Release : 2013-11-30
Category : Technology & Engineering
ISBN : 3642305741
The Springer Handbook of Bio-/Neuro-Informatics is the first published book in one volume that explains together the basics and the state-of-the-art of two major science disciplines in their interaction and mutual relationship, namely: information sciences, bioinformatics and neuroinformatics. Bioinformatics is the area of science which is concerned with the information processes in biology and the development and applications of methods, tools and systems for storing and processing of biological information thus facilitating new knowledge discovery. Neuroinformatics is the area of science which is concerned with the information processes in biology and the development and applications of methods, tools and systems for storing and processing of biological information thus facilitating new knowledge discovery. The text contains 62 chapters organized in 12 parts, 6 of them covering topics from information science and bioinformatics, and 6 cover topics from information science and neuroinformatics. Each chapter consists of three main sections: introduction to the subject area, presentation of methods and advanced and future developments. The Springer Handbook of Bio-/Neuroinformatics can be used as both a textbook and as a reference for postgraduate study and advanced research in these areas. The target audience includes students, scientists, and practitioners from the areas of information, biological and neurosciences. With Forewords by Shun-ichi Amari of the Brain Science Institute, RIKEN, Saitama and Karlheinz Meier of the University of Heidelberg, Kirchhoff-Institute of Physics and Co-Director of the Human Brain Project.
Author : Sami Khuri
Publisher : Springer Science & Business Media
Page : 245 pages
File Size : 32,31 MB
Release : 2010-08-18
Category : Computers
ISBN : 3642150195
This book constitutes the thoroughly refereed proceedings of the First International Conference on InformationTechnology in Bio- and Medical Informatics, held in Bilbao, Spain, in September 2010. The 14 selected long papers and 8 selected short papers are divided in the following groups:Workflow management and database; Decision support and data management in biomedicine; Medical data modelling and information retrieval; Data mining in bioinformatics; Knowledge representation and data management in bioinformatics; Biological data and signal processing.
Author : Steffen Staab
Publisher : Springer Science & Business Media
Page : 809 pages
File Size : 24,16 MB
Release : 2010-03-14
Category : Computers
ISBN : 3540926739
An ontology is a formal description of concepts and relationships that can exist for a community of human and/or machine agents. The notion of ontologies is crucial for the purpose of enabling knowledge sharing and reuse. The Handbook on Ontologies provides a comprehensive overview of the current status and future prospectives of the field of ontologies considering ontology languages, ontology engineering methods, example ontologies, infrastructures and technologies for ontologies, and how to bring this all into ontology-based infrastructures and applications that are among the best of their kind. The field of ontologies has tremendously developed and grown in the five years since the first edition of the "Handbook on Ontologies". Therefore, its revision includes 21 completely new chapters as well as a major re-working of 15 chapters transferred to this second edition.
Author : Gil Alterovitz
Publisher : John Wiley & Sons
Page : 306 pages
File Size : 28,13 MB
Release : 2011-04-20
Category : Medical
ISBN : 1119995833
There is an increasing need throughout the biomedical sciences for a greater understanding of knowledge-based systems and their application to genomic and proteomic research. This book discusses knowledge-based and statistical approaches, along with applications in bioinformatics and systems biology. The text emphasizes the integration of different methods for analysing and interpreting biomedical data. This, in turn, can lead to breakthrough biomolecular discoveries, with applications in personalized medicine. Key Features: Explores the fundamentals and applications of knowledge-based and statistical approaches in bioinformatics and systems biology. Helps readers to interpret genomic, proteomic, and metabolomic data in understanding complex biological molecules and their interactions. Provides useful guidance on dealing with large datasets in knowledge bases, a common issue in bioinformatics. Written by leading international experts in this field. Students, researchers, and industry professionals with a background in biomedical sciences, mathematics, statistics, or computer science will benefit from this book. It will also be useful for readers worldwide who want to master the application of bioinformatics to real-world situations and understand biological problems that motivate algorithms.
Author : Russ Altman
Publisher : World Scientific
Page : 682 pages
File Size : 48,37 MB
Release : 2002
Category : Computers
ISBN : 9789812776303
The Pacific Symposium on Biocomputing (PSB 2003) is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. The rigorously peer-reviewed papers and presentations are collected in this archival proceedings volume. PSB 2003 brings together top researchers from the US, the Asia-Pacific region and around the world to exchange research findings and address open issues in all aspects of computational biology. PSB is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology. Contents: Gene Regulation; Genome, Pathway, and Interaction Bioinformatics; Informatics Approaches in Structural Genomics; Genome-Wide Analysis and Comparative Genomics; Linking Biomedical Language, Information and Knowledge; Human Genome Variation: Haplotypes, Linkage Disequilibrium, and Populations; Biomedical Ontologies; Special Paper. Readership: Graduate students, academics and industrialists in bioinformatics, biochemists, computer scientists and researchers in neural networks.
